公开(公告)号：US08545487B2

公开(公告)日：2013-10-01

申请号：US12315829

申请日：2008-12-05

申请人： David Muller ,  Thomas Ryan

发明人： David Muller ,  Thomas Ryan

IPC分类号： A61B17/22

CPC分类号： A61F9/0079 ,  A61B18/18 ,  A61B18/1815 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0661

摘要： Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

公开(公告)号：US08433103B2

公开(公告)日：2013-04-30

申请号：US11898188

申请日：2007-09-10

申请人： Marc D. Friedman ,  Pablo Casaverde ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  David Muller ,  Faisal Bashir ,  David J. Hitchcock

发明人： Marc D. Friedman ,  Pablo Casaverde ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  David Muller ,  Faisal Bashir ,  David J. Hitchcock

IPC分类号： G06K9/00

CPC分类号： G06K9/00604 ,  G06K9/00255

摘要： A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.

公开(公告)号：US08391567B2

公开(公告)日：2013-03-05

申请号：US13196617

申请日：2011-08-02

申请人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

发明人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

IPC分类号： G06K9/00 ,  A61B3/14 ,  A61B3/10

CPC分类号： H04N7/18 ,  A61B3/1216 ,  A61B3/14 ,  G06K9/00597

摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.

公开(公告)号：US20120022319A1

公开(公告)日：2012-01-26

申请号：US12954456

申请日：2010-11-24

申请人： David Muller

发明人： David Muller

IPC分类号： A61F2/04

CPC分类号： A61B17/083 ,  A61B2017/00818 ,  A61F5/0036

摘要： Systems and methods maintain a fold, e.g., an intussusception, formed in a portion of the stomach wall. In one example, a system includes a holding device that is positioned at least partially in a stomach and receives a portion of a wall of the stomach. The holding device includes a first section connected to a second section. The holding device is operable to move the second section relative to the first section into a position in which a cavity is defined between the first section and the second section. The cavity receives the portion of the wall of the stomach. The system includes a securing device that is positionable around the second section while the portion of the stomach wall is received by the cavity. The securing device is operable to provide a force around the second section to maintain the portion of the stomach wall stably in the cavity.

摘要翻译： 系统和方法保持在胃壁的一部分中形成的折叠，例如肠套叠。 在一个示例中，系统包括至少部分地定位在胃中并且容纳胃的一部分壁的保持装置。 保持装置包括连接到第二部分的第一部分。 保持装置可操作以将第二部分相对于第一部分移动到在第一部分和第二部分之间限定空腔的位置。 空腔容纳胃壁的一部分。 该系统包括固定装置，该固定装置可围绕第二部分定位，同时胃壁的部分被空腔容纳。 固定装置可操作以围绕第二部分提供力以将胃壁的该部分稳定地保持在空腔中。

公开(公告)号：US08014571B2

公开(公告)日：2011-09-06

申请号：US11798500

申请日：2007-05-14

申请人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

发明人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

IPC分类号： G06K9/00 ,  A61B3/14 ,  A61B3/10

CPC分类号： H04N7/18 ,  A61B3/1216 ,  A61B3/14 ,  G06K9/00597

摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.

摘要翻译： 多模式生物识别系统捕获并处理虹膜和视网膜的图像以进行生物识别。 另一个多模态眼系统捕获并处理虹膜和/或从受试者的双眼的图像。 基于这些系统提供的数据的生物识别技术比使用仅包括虹膜的数据或仅来自单个眼睛的视网膜的生物识别技术更准确和鲁棒。 示例性实施例将光子发射到虹膜和双眼视网膜，虹膜图像传感器，当虹膜反射发射的光时捕获虹膜的图像;视网膜图像传感器，其在视网膜反射时捕获视网膜的图像 以及控制虹膜和视网膜照明源的控制器，其中虹膜的捕获图像和视网膜的捕获图像包含生物特征数据。

公开(公告)号：US20110118716A1

公开(公告)日：2011-05-19

申请号：US12915646

申请日：2010-10-29

申请人： David Muller ,  John Marshall

发明人： David Muller ,  John Marshall

IPC分类号： A61B18/02 ,  A61B18/18

CPC分类号： A61F9/007 ,  A61B18/1815 ,  A61B2018/00029 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61K38/1841 ,  A61M35/00 ,  A61M2210/0612

摘要： Systems and methods stabilize corneal tissue after treatment of the corneal tissue. For example, thermokeratoplasty may be applied to the corneal tissue to address disorders associated with abnormal shaping of the cornea. To stabilize the desired structural changes caused by the treatment, embodiments apply ophthalmic formulations that help to inhibit wound healing. Wound healing may occur in response to the application of the treatment and may produce further structural changes that mitigate or alter the desired effects of the treatment.

摘要翻译： 系统和方法在角膜组织治疗后稳定角膜组织。 例如，热角膜成形术可以应用于角膜组织以解决与角膜异常成形相关的疾病。 为了稳定由治疗引起的期望的结构变化，实施方案应用有助于抑制伤口愈合的眼用制剂。 伤口愈合可能会因应用治疗而发生，并可能产生进一步的结构变化，从而减轻或改变预期的治疗效果。

公开(公告)号：US20100069990A1

公开(公告)日：2010-03-18

申请号：US12622139

申请日：2009-11-19

申请人： David Muller ,  Xiaoyi Min

发明人： David Muller ,  Xiaoyi Min

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3682

摘要： Techniques are provided for estimating optimal atrioventricular pacing delay values for use in pacing the ventricles based on features of an intracardiac electrogram (IEGM) signal. Briefly, atrioventricular pacing delay pacing values are set based upon the location of atrial repolarization events within the IEGM. In one example, the end of an atrial repolarization is identified, then the interval from the atrial depolarization to the end of the atrial repolarization is measured. The atrioventricular pacing delay is then set by subtracting an offset value from that interval so as to time delivery of V-pulses prior the end of atrial repolarization. In this manner, atrioventricular pacing delay values are set based only IEGM signals and hence can be set to optimal/preferred values by the device itself without requiring surface electrocardiogram (EKG) signals and Doppler echocardiography or other cardiac performance monitoring techniques.

摘要翻译： 提供技术用于基于心内电描记图（IEGM）信号的特征来估计用于起搏心室的最佳房室起搏延迟值。 简而言之，房室起搏延迟起搏值是根据IEGM内心房复极化事件的位置设定的。 在一个实例中，确定了心房复极化的终点，然后测量从心房去极化到心房复极末期的间隔。 然后通过从该间隔减去偏移值来设置房室起搏延迟，以便在心房复极化结束前的时间递送V脉冲。 以这种方式，房室起搏延迟值仅基于IEGM信号设置，因此可以通过装置本身设置为最佳/优选值，而不需要表面心电图（EKG）信号和多普勒超声心动图或其他心脏性能监测技术。

公开(公告)号：US07643878B1

公开(公告)日：2010-01-05

申请号：US11366930

申请日：2006-03-01

申请人： David Muller ,  Xiaoyi Min

发明人： David Muller ,  Xiaoyi Min

IPC分类号： A61N1/62

CPC分类号： A61N1/368 ,  A61N1/3682

摘要： Techniques are provided for estimating optimal atrioventricular pacing delay values for use in pacing the ventricles based on features of an intracardiac electrogram (IEGM) signal. Briefly, atrioventricular pacing delay pacing values are set based upon the location of atrial repolarization events within the IEGM. In one example, the end of an atrial repolarization is identified, then the interval from the atrial depolarization to the end of the atrial repolarization is measured. The atrioventricular pacing delay is then set by subtracting an offset value from that interval so as to time delivery of V-pulses prior the end of atrial repolarization. In this manner, atrioventricular pacing delay values are set based only IEGM signals and hence can be set to optimal/preferred values by the device itself without requiring surface electrocardiogram (EKG) signals and Doppler echocardiography or other cardiac performance monitoring techniques.

摘要翻译： 提供技术用于基于心内电描记图（IEGM）信号的特征来估计用于起搏心室的最佳房室起搏延迟值。 简而言之，房室起搏延迟起搏值是根据IEGM内的心房复极化事件的位置设定的。 在一个实例中，确定了心房复极化的终点，然后测量从心房去极化到心房复极末期的间隔。 然后通过从该间隔减去偏移值来设置房室起搏延迟，以便在心房复极化结束前的时间递送V脉冲。 以这种方式，房室起搏延迟值仅基于IEGM信号设置，因此可以通过装置本身设置为最佳/优选值，而不需要表面心电图（EKG）信号和多普勒超声心动图或其他心脏性能监测技术。

公开(公告)号：US20090187173A1

公开(公告)日：2009-07-23

申请号：US12018473

申请日：2008-01-23

申请人： David Muller

发明人： David Muller

IPC分类号： A61F9/08 ,  A61B18/18

CPC分类号： A61F9/013 ,  A61B18/14 ,  A61F9/0079 ,  A61F2009/00853 ,  A61F2009/00872

摘要： A system for applying therapy to an eye includes an energy source and a conducting element operably connected to the energy source and configured to direct energy from the energy source to an application end of the conducting element. The application end includes an eye contact portion configured to apply the energy to an eye feature and provides a reshaping mold to reshape the eye feature as the eye feature responds to the application of the energy. The eye contact portion may have a concave curvature and may be positioned in direct contact with the eye feature. In addition, the eye feature may be the cornea of the eye. In a particular embodiment, the energy source is an electrical energy source, the conducting element comprises an outer electrode and an inner electrode separated by a gap, and the eye contact portion is positioned on the inner electrode.

摘要翻译： 用于向眼睛施加治疗的系统包括能量源和可操作地连接到能量源并被配置为将能量从能量源引导到导电元件的应用端的导电元件。 应用端包括配置成将能量施加到眼睛特征的眼睛接触部分，并且当眼睛特征响应于能量的应用时，提供重塑模具以重塑眼睛特征。 眼睛接触部分可以具有凹曲率并且可以定位成与眼睛特征直接接触。 此外，眼睛特征可以是眼睛的角膜。 在特定实施例中，能量源是电能源，导电元件包括​​由电极间隔开的外部电极和内部电极，并且眼睛接触部分位于内部电极上。

公开(公告)号：US20090149842A1

公开(公告)日：2009-06-11

申请号：US12315829

申请日：2008-12-05

申请人： David Muller ,  Thomas Ryan

发明人： David Muller ,  Thomas Ryan

IPC分类号： A61B18/20

CPC分类号： A61F9/0079 ,  A61B18/18 ,  A61B18/1815 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0661

摘要： Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

摘要翻译： 根据选定的图案，在角膜的角膜原纤维中产生热量。 热量导致对应于所选图案的角膜原纤维从第一结构转变到第二结构。 第二种结构提供了所需的角膜重塑。 然后根据所选择的图案，在角膜原纤维区域中激活交联剂。 交联剂防止角膜原纤维从第二结构改变。 因此，在角膜组织中已经实现所需的结构变化之后，实施例可稳定角膜组织并提高其生物力学强度。 因此，这些实施例有助于保持期望的角膜重塑。