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公开(公告)号:US20120214807A1
公开(公告)日:2012-08-23
申请号:US13281482
申请日:2011-10-26
申请人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: A61K31/5377 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/454 , A61K31/453 , A61K31/4439 , C07D471/04 , C07D405/14 , C07D413/14 , C07D405/04 , C07D409/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/5025
CPC分类号: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供通式I的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US08062768B2
公开(公告)日:2011-11-22
申请号:US12125296
申请日:2008-05-22
申请人: Yangang Liang , Shengxia Liu , Kelly Scott Chichak , Qing Ye , Jie Liu
发明人: Yangang Liang , Shengxia Liu , Kelly Scott Chichak , Qing Ye , Jie Liu
IPC分类号: H01L51/54 , C09K11/06 , C07D213/02 , C07D401/10 , C07D401/14 , C07D405/14
CPC分类号: C07D405/10 , C07D213/06 , C07D213/127 , C07D213/30 , C07D213/643 , C07D401/10 , Y10S428/917
摘要: Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R2 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.
摘要翻译: 式I的有机化合物可用于光电子器件,其中R 1在每次出现时独立地为C 1 -C 20脂族基,C 3 -C 20芳族基或C 3 -C 20脂环族基; R 2在每次出现时独立地为C 1 -C 20脂族基团,C 3 -C 20芳族基团或C 3 -C 20脂环族基团; a在每次出现时独立地为0-4的整数; b在每次出现时独立地为0-3的整数; Ar1是直接键或杂芳基,芳基或烷基或环烷基; Ar 2是杂芳基,芳基或烷基或环烷基; c为0,1或2; n为2-4的整数。
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公开(公告)号:US20110190272A1
公开(公告)日:2011-08-04
申请号:US12990711
申请日:2009-05-06
申请人: Kevin Daly , Del Valle David , David Scott , Qing Ye
发明人: Kevin Daly , Del Valle David , David Scott , Qing Ye
IPC分类号: A61K31/551 , C07D237/28 , A61K31/502 , C07D403/12 , C07D401/12 , C07D413/12 , A61K31/5377 , A61P35/00
CPC分类号: C07D403/04 , C07D237/28 , C07D401/04 , C07D417/04 , C07D487/04
摘要: The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-IR kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.
摘要翻译: 本发明涉及具有CSF-1R激酶抑制活性的式(I)化合物或其药学上可接受的盐,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号:US07989476B2
公开(公告)日:2011-08-02
申请号:US12350629
申请日:2009-01-08
申请人: Kelly Scott Chichak , Qing Ye , Yangang Liang , Shengxia Liu , Rui Wang
发明人: Kelly Scott Chichak , Qing Ye , Yangang Liang , Shengxia Liu , Rui Wang
IPC分类号: A01N43/40 , C07D213/04
CPC分类号: C07D213/16 , C07D213/53
摘要: Compound of formula C is made by reacting a compound of formula A with an pyridyl boronic acid or pyridyl borate ester to form a compound of formula B; and combining the compound of formula B with a pyridyl dihalide to form the compound of C; wherein R3, R4, R5, R6 and R7 are, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; X is, independently at each occurrence, CH or N; Y is chloro or bromo; Z is bromo or iodo; and when Y is bromo, Z is iodo; d, e, and g are, independently at each occurrence, an integer ranging from 0-4; f is an integer ranging from 0-2; and h is an integer ranging from 0-3.
摘要翻译: 式C化合物通过使式A的化合物与吡啶基硼酸或吡啶基硼酸酯反应形成式B的化合物而制备; 并将式B化合物与吡啶基二卤化物结合形成C的化合物; 其中R 3,R 4,R 5,R 6和R 7在每次出现时独立地为C 1 -C 20脂族基团,C 3 -C 20芳族基团或C 3 -C 20脂环族基团; 每次出现时,X独立地为CH或N; Y是氯或溴; Z是溴或碘; 当Y为溴时,Z为碘; d,e和g各自独立地为0-4的整数; f是0-2的整数; h为0-3的整数。
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公开(公告)号:US07955720B2
公开(公告)日:2011-06-07
申请号:US12810197
申请日:2008-12-06
申请人: Qing Ye , Jie Liu , Yangang Liang , Shengxia Liu
发明人: Qing Ye , Jie Liu , Yangang Liang , Shengxia Liu
IPC分类号: C09K11/02
CPC分类号: H01L51/0085 , C08F26/06 , C08F126/06 , C08F226/06 , C09K11/06 , C09K2211/1466 , H01L51/004 , H01L51/0043 , H05B33/14
摘要: The invention relates to a polymer comprising structural unit of formula II: wherein R1, R2, R3, R4, R5, R6 and R7 are independently at each occurrence a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a, b, d, e and f are independently at each occurrence 0, or an integer ranging from 1 to 4; c and g are independently at each occurrence 0, or an integer ranging from 1 to 3. In another aspect, the invention relates to monomers for preparing the polymers. In yet another aspect, the invention relates to an optical electronic device comprising a polymer comprising structural unit of formula II.
摘要翻译: 本发明涉及包含式II结构单元的聚合物:其中R1,R2,R3,R4,R5,R6和R7在每次出现时独立地为C1-C20脂族基团,C3-C20芳族基团或C3- C20脂环族基; a,b,d,e和f各自独立地为0或1〜4的整数; c和g在每次出现时独立地为0,或整数为1至3.在另一方面,本发明涉及用于制备聚合物的单体。 在另一方面,本发明涉及一种光学电子器件,其包括含有式II结构单元的聚合物。
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公开(公告)号:US20110121235A1
公开(公告)日:2011-05-26
申请号:US13055121
申请日:2009-06-05
CPC分类号: C07F5/027 , Y10S428/917
摘要: Compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is 0, 1 or 2; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is an integer ranging from 1-7; and n is an integer ranging from 2-4.
摘要翻译: 式I化合物可用于光电器件,其中R 1在每次出现时独立地为C 1 -C 20脂族基团,C 3 -C 20芳族基团或C 3 -C 20脂环族基团; a在每次出现时独立地为0-4的整数; b为0,1或2; Ar1是直接键或杂芳基,芳基或烷基或环烷基; Ar 2是杂芳基,芳基或烷基或环烷基; c为1-7的整数; n为2-4的整数。
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公开(公告)号:US07932336B2
公开(公告)日:2011-04-26
申请号:US12277373
申请日:2008-11-25
申请人: James Pickett , Qing Ye , Daniel Steiger
发明人: James Pickett , Qing Ye , Daniel Steiger
IPC分类号: C08F134/02
CPC分类号: B32B27/08 , B32B27/18 , B32B27/365 , B32B2270/00 , B32B2398/10 , B32B2398/20 , Y10T428/31507 , Y10T428/31663 , Y10T428/31667 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935
摘要: Copolymers are disclosed comprising structural units derived from α-methylene-γ-butyrolactone, styrene, methyl methacrylate and acrylonitrile. The copolymers may be used as protective layers in multilayer articles that include UV sensitive substrate materials. The multilayer articles may also include a silicone hardcoat.
摘要翻译: 公开了包含衍生自α-亚甲基-γ-丁内酯,苯乙烯,甲基丙烯酸甲酯和丙烯腈的结构单元的共聚物。 共聚物可以用作多层制品中的保护层,其中包括紫外线敏感的基材。 多层制品还可以包括硅氧烷硬涂层。
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公开(公告)号:US20100171078A1
公开(公告)日:2010-07-08
申请号:US12350594
申请日:2009-01-08
申请人: Kelly Scott Chichak , Qing Ye
发明人: Kelly Scott Chichak , Qing Ye
IPC分类号: C09K11/06 , C07D213/06
CPC分类号: C07D401/14
摘要: Compounds of formula I may be used in optoelectronic devices wherein R1 and R2 are, independently at each occurrence, H, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is an integer ranging from 0-2; b is 1 or 2; c is an integer ranging from 0-4; and Ar1 and Ar2 are independently heteroaryl.
摘要翻译: 式I化合物可以用于其中R 1和R 2在每次出现时独立地为H,C 1 -C 20脂族基团,C 3 -C 20芳族基团或C 3 -C 20脂环族基团的光电子器件; a是0-2的整数; b为1或2; c是0-4的整数; Ar 1和Ar 2独立地是杂芳基。
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公开(公告)号:US07740942B2
公开(公告)日:2010-06-22
申请号:US11610076
申请日:2006-12-13
申请人: Qing Ye , Jie Liu , Joyce Hung
发明人: Qing Ye , Jie Liu , Joyce Hung
IPC分类号: B29C39/00
CPC分类号: H01L51/0035 , C08F226/02 , H01L51/0043 , H01L51/5088 , Y10S428/917 , Y10T428/24 , Y10T428/31533 , Y10T428/31721
摘要: The invention provides an opto-electronic device comprising at least one sulfonated aromatic condensation copolymer or at least one phosphonated aromatic condensation copolymer. The at least one sulfonated aromatic condensation copolymer is selected from sulfonated polyarylethers, sulfonated polyimides, sulfonated polyphenylene oxides, sulfonated polyarylenes, sulfonated polyphosphazenes, and the at least one phosphonated aromatic condensation copolymer is selected from phosphonated polyarylethers, phosphonated polyimides, phosphonated polyphenylene oxides, phosphonated polyarylenes, phosphonated polyphosphazenes and combinations thereof. The sulfonated polyarylether is a sulfonated polyarylether block copolymer having sulfonated polyaryletherketone blocks, sulfonated polyethersulfone blocks, or combinations thereof.
摘要翻译: 本发明提供了包含至少一种磺化芳族缩合共聚物或至少一种膦酸化芳族缩合共聚物的光电装置。 所述至少一种磺化芳族缩合共聚物选自磺化聚芳基醚,磺化聚酰亚胺,磺化聚苯醚,磺化聚亚芳基,磺化聚磷腈,并且所述至少一种膦酸化芳族缩合共聚物选自膦酸化的聚芳基醚,膦酸化的聚酰亚胺,膦酸化的聚苯醚,磷酸化的 聚亚芳基,膦酸化聚磷腈及其组合。 磺化聚芳基醚是具有磺化聚芳醚酮嵌段,磺化聚醚砜嵌段或其组合的磺化聚芳醚嵌段共聚物。
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公开(公告)号:US20090143553A1
公开(公告)日:2009-06-04
申请号:US12277373
申请日:2008-11-25
申请人: James Pickett , Qing Ye , Daniel Steiger
发明人: James Pickett , Qing Ye , Daniel Steiger
IPC分类号: C08F24/00
CPC分类号: B32B27/08 , B32B27/18 , B32B27/365 , B32B2270/00 , B32B2398/10 , B32B2398/20 , Y10T428/31507 , Y10T428/31663 , Y10T428/31667 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935
摘要: Copolymers are disclosed comprising structural units derived from α-methylene-γ-butyrolactone, styrene, methyl methacrylate and acrylonitrile. The copolymers may be used as protective layers in multilayer articles that include UV sensitive substrate materials. The multilayer articles may also include a silicone hardcoat.
摘要翻译: 公开了包含衍生自α-亚甲基-γ-丁内酯,苯乙烯,甲基丙烯酸甲酯和丙烯腈的结构单元的共聚物。 共聚物可以用作多层制品中的保护层,其中包括紫外线敏感的基材。 多层制品还可以包括硅氧烷硬涂层。
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