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公开(公告)号：US08545831B2
公开(公告)日：2013-10-01
申请号：US11443594
申请日：2006-05-31
申请人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
发明人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
IPC分类号： A61K31/77
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.
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42.发明申请METHODS OF IDENTIFYING POTENTIAL COMPONENTS FOR TARGETED DRUG DELIVERY COMPOSITIONS 有权识别针对药物组合物的潜在成分的方法公开(公告)号：US20100247683A1
公开(公告)日：2010-09-30
申请号：US12731822
申请日：2010-03-25
申请人： Josee Roy , Victor Kelley , Roger E. Harrington
发明人： Josee Roy , Victor Kelley , Roger E. Harrington
摘要： Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.
摘要翻译： 提供了将活性剂优先分配给损伤部位的组合物的制备方法。 组合物可以包含具有亲水性质的聚合物和一种或多种活性剂，例如包含亲水金属离子的化合物。 因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的。 还公开了用于鉴定这些组合物的合适组分的方法。
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43.发明申请Compositions and Methods for Preferential Distribution of Active Agents to Injury Sites 有权活性剂优先分配给损伤部位的组成和方法公开(公告)号：US20100247677A1
公开(公告)日：2010-09-30
申请号：US12411572
申请日：2009-03-26
申请人： Josee Roy , Toya Kimble
发明人： Josee Roy , Toya Kimble
CPC分类号： A61K33/06 , A61K9/0019 , A61K45/06 , A61K47/10
摘要： Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
摘要翻译： 提供组合物用于将活性剂优先分配到损伤部位。 这样的组合物可以包含具有亲水性质的配体和一种或多种活性剂，例如包含亲水金属离子的化合物。 因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的，使得活性剂与递送配体的结合和活性剂向靶位点的释放不依赖于酶活性。 还公开了使用这些组合物的方法。
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44.发明申请SITE LOCALIZATION AND METHODS FOR MONITORING TREATMENT OF DISTURBED BLOOD VESSELS 有权用于监测干扰血管的处理的站点本地化和方法公开(公告)号：US20100247441A1
公开(公告)日：2010-09-30
申请号：US12411666
申请日：2009-03-26
申请人： Josee Roy , Roger Harrington
发明人： Josee Roy , Roger Harrington
CPC分类号： G01N33/5091 , A61K49/006 , G01N33/58 , G01N2800/32
摘要： Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.
摘要翻译： 提供了鉴别血管缺陷和治疗这些缺陷的方法。 所述方法包括向患者施用包含能够在血管或血管附近存在缺陷的标记的递送配体的组合物。 在一些实施方案中，递送配体可携带一种或多种活性剂至缺陷。
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45.发明申请公开(公告)号：US20070012323A1
公开(公告)日：2007-01-18
申请号：US11443594
申请日：2006-05-31
申请人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
发明人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
IPC分类号： A61B19/00
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.
摘要翻译： 在本发明中，申请人描述了治疗受损的心血管因子和心血管疾病的方法和组合物，包括低血压，动脉粥样硬化病变，易损斑块和急性心肌梗死。 申请人证明了生物膜密封剂积聚在受损血管壁上的能力，有助于改善组织损伤后的平均动脉压。 申请人描述了使用包含至少一种生物膜密封剂和一种用于预防性治疗的生物活性剂的制剂，例如它们可以同时施用于侵入性治疗干预或在侮辱之后（即损伤后或手术后）。 或者，这些方法和组合物可用于降低发病后心血管疾病的严重性。
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