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    Combination Local Delivery Using a Stent
    4.
    发明申请
    Combination Local Delivery Using a Stent 审中-公开
    组合使用支架本地交付

    公开(公告)号：US20100092534A1

    公开(公告)日：2010-04-15

    申请号：US12249576

    申请日：2008-10-10

    申请人： Ayala Hezi-Yamit ,  Iskender Matt Bilge ,  Jennifer Wong ,  Carol Sullivan ,  Natividad Vasquez

    发明人： Ayala Hezi-Yamit ,  Iskender Matt Bilge ,  Jennifer Wong ,  Carol Sullivan ,  Natividad Vasquez

    IPC分类号： A61F2/04 ,  A61K31/58 ,  A61K31/4355

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/45

    摘要： Described herein are implantable medical devices useful in treating vascular conditions such as restenosis. In one embodiment, stents are described in which a combination of bioactive agents is described for local delivery in the vasculature. The combination of bioactive agents comprises at least one compound capable of inhibiting smooth muscle cell proliferation and at least one compound capable of mitigating MCP- and/or TF induction. For example, a compound capable of inhibiting smooth muscle cell proliferation is a mTOR inhibitor and a compound capable of mitigating MCP-1 and/or TF induction is a corticosteroid.

    摘要翻译： 本文描述了可用于治疗诸如再狭窄的血管病变的可植入医疗装置。 在一个实施方案中，描述了支架，其中描述了生物活性剂的组合用于脉管系统中的局部递送。 生物活性剂的组合包含至少一种能够抑制平滑肌细胞增殖的化合物和至少一种能够减轻MCP-和/或TF诱导的化合物。 例如，能够抑制平滑肌细胞增殖的化合物是mTOR抑制剂，能够缓解MCP-1和/或TF诱导的化合物是皮质类固醇。

    NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS FOR THE MANAGEMENT OF PAIN
    5.
    发明申请
    NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS FOR THE MANAGEMENT OF PAIN 有权

    公开(公告)号：US20230057437A1

    公开(公告)日：2023-02-23

    申请号：US18045556

    申请日：2022-10-11

    申请人： Carol Sullivan ,  Neil Barman ,  Dwayne S. Yamasaki

    发明人： Carol Sullivan ,  Neil Barman ,  Dwayne S. Yamasaki

    IPC分类号： G16H20/30 ,  A61N2/00 ,  A61B5/00 ,  G16H50/30 ,  G16H20/40 ,  A61B18/02 ,  A61F7/12 ,  A61N7/00

    摘要： Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

    Medical devices to treat or inhibit restenosis
    7.
    发明申请
    Medical devices to treat or inhibit restenosis 审中-公开
    用于治疗或抑制再狭窄的医疗器械

    公开(公告)号：US20070142905A1

    公开(公告)日：2007-06-21

    申请号：US11567821

    申请日：2006-12-07

    申请人： Ayala Hezi-Yamit ,  Carol Sullivan ,  Jennifer Wong

    发明人： Ayala Hezi-Yamit ,  Carol Sullivan ,  Jennifer Wong

    IPC分类号： A61F2/02 ,  A61F2/82

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/436

    摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain NF-kappaB inhibitors, particularly certain dialkyl fumarates, are disclosed. Dimethyl fumarate is a particularly preferred dialkyl fumarate. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the dialkyl fumarate with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-dialkyl fumarate blends are disclosed. Additionally, medical devices having a coating comprising at least one dialkyl fumarate in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

    摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些NF-κB抑制剂，特别是某些二烷基富马酸盐的包衣的可植入医疗器械。 富马酸二甲酯是特别优选的富马酸二烷基酯。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将富马酸二烷基酯与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 富马酸二烷基酯混合物组成的医疗装置。 此外，还公开了具有包含至少一种富马酸二烷基酯与至少一种另外的治疗剂组合的涂层的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

    Compositions and methods for treating a damaged cardiovascular element
    8.
    发明申请
    Compositions and methods for treating a damaged cardiovascular element 失效
    用于治疗受损的心血管元件的组合物和方法

    公开(公告)号：US20070012323A1

    公开(公告)日：2007-01-18

    申请号：US11443594

    申请日：2006-05-31

    申请人： Josee Roy ,  Hezi-Yamit Ayala ,  Carol Sullivan ,  Mingfei Chen

    发明人： Josee Roy ,  Hezi-Yamit Ayala ,  Carol Sullivan ,  Mingfei Chen

    IPC分类号： A61B19/00

    CPC分类号： A61K31/765 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/00 ,  A61K45/06 ,  A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/402 ,  A61L2400/06 ,  C08L71/02

    摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.

    摘要翻译： 在本发明中，申请人描述了治疗受损的心血管因子和心血管疾病的方法和组合物，包括低血压，动脉粥样硬化病变，易损斑块和急性心肌梗死。 申请人证明了生物膜密封剂积聚在受损血管壁上的能力，有助于改善组织损伤后的平均动脉压。 申请人描述了使用包含至少一种生物膜密封剂和一种用于预防性治疗的生物活性剂的制剂，例如它们可以同时施用于侵入性治疗干预或在侮辱之后（即损伤后或手术后）。 或者，这些方法和组合物可用于降低发病后心血管疾病的严重性。