公开(公告)号：US07135189B2

公开(公告)日：2006-11-14

申请号：US09935442

申请日：2001-08-23

Applicant: David Knapp

Inventor： David Knapp

IPC: A61F13/00 ,  A61F2/00

CPC classification number: A61L31/16 ,  A61K31/198 ,  A61K38/363 ,  A61K38/4833 ,  A61K45/06 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/622 ,  A61K2300/00

Abstract: A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.

公开(公告)号：US20050023477A1

公开(公告)日：2005-02-03

申请号：US10874127

申请日：2004-06-21

Applicant: Daniel Archer ,  Brock Beauchamp ,  G. Joseph Mauger ,  Karl Nelson ,  Michael Mercer ,  David Pletcher ,  Vincent Riot ,  James Schek ,  David Knapp

Inventor： Daniel Archer ,  Brock Beauchamp ,  G. Joseph Mauger ,  Karl Nelson ,  Michael Mercer ,  David Pletcher ,  Vincent Riot ,  James Schek ,  David Knapp

IPC: G01J1/00 ,  G01T1/24 ,  G01T7/00 ,  G01V5/00

CPC classification number: G01V5/0075 ,  G01T7/00 ,  G01V5/0083

Abstract: A portable radioactive-material detection system capable of detecting radioactive sources moving at high speeds. The system has at least one radiation detector capable of detecting gamma-radiation and coupled to an MCA capable of collecting spectral data in very small time bins of less than about 150 msec. A computer processor is connected to the MCA for determining from the spectral data if a triggering event has occurred. Spectral data is stored on a data storage device, and a power source supplies power to the detection system. Various configurations of the detection system may be adaptably arranged for various radiation detection scenarios. In a preferred embodiment, the computer processor operates as a server which receives spectral data from other networked detection systems, and communicates the collected data to a central data reporting system.

Abstract translation: 一种便携式放射性物质检测系统，能够检测高速运动的放射源。 该系统具有至少一个能够检测伽马辐射并耦合到能够在小于约150毫秒的非常小的时间段中收集光谱数据的MCA的辐射检测器。 计算机处理器连接到MCA，用于根据光谱数据确定是否发生触发事件。 光谱数据存储在数据存储设备上，电源向检测系统供电。 检测系统的各种配置可以适用于各种辐射检测场景。 在优选实施例中，计算机处理器作为从其他联网检测系统接收频谱数据并将收集的数据传送到中央数据报告系统的服务器。

公开(公告)号：US06762282B2

公开(公告)日：2004-07-13

申请号：US10436965

申请日：2003-05-13

Applicant: Robert A. Herrmann ,  David Knapp

Inventor： Robert A. Herrmann ,  David Knapp

IPC: C07K1113

CPC classification number: C07C381/00 ,  C08B37/00 ,  C08B37/0012

Abstract: A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation. The S-nitrosylated species can be isolated, for example, by a process in which the precipitate is removed from the solution (e.g., by centrifugation) and the aqueous solvent remaining in the precipitate is sublimated (e.g., by freezing the precipitate and subjecting it to a vacuum). The isolated S-nitrosylated product is preferably protected from heat, light, moisture and oxygen.

Abstract translation: 提供了生产S-亚硝基化物质的方法。 该方法包括：（a）提供包含硫醇和含亚硝酸盐的物质的脱氧碱性水溶液; （b）通过向溶液中加入酸来酸化溶液，同时混合溶液（例如通过剧烈搅拌该溶液）以产生S-亚硝基化物质; 和（c）分离S-亚硝基化物质。 含有亚硝酸盐的物质可以是例如无机亚硝酸盐，例如碱金属亚硝酸盐或有机亚硝酸盐，例如亚硝酸烷基酯（例如亚硝酸亚乙酯，亚硝酸戊酯，亚硝酸异丁酯或亚硝酸叔丁酯）。 硫醇优选为含硫醇的多糖，含硫醇的脂蛋白，含巯基的氨基酸或含硫醇的蛋白质，更优选含硫醇的多糖如硫醇化环糊精。 在许多优选实施方案中，S-亚硝基化物质不溶于酸化溶液，在形成时沉淀。 S-亚硝基化物质可以例如通过其中从溶液中除去沉淀物（例如通过离心）并且残留在沉淀物中的水性溶剂升华的方法分离（例如，通过冷冻沉淀物并使其沉淀 到真空）。 分离的S-亚硝基化产物优选保护免受热，光，水分和氧气的影响。

公开(公告)号：US06470486B1

公开(公告)日：2002-10-22

申请号：US09574693

申请日：2000-05-17

Applicant: David Knapp

Inventor： David Knapp

IPC: G06F1750

CPC classification number: G06F17/5045 ,  G06F17/505

Abstract: A delay-optimizing technology-mapping process for an electronic design automation system selects the best combination of library devices to use in a forward and a backward sweep of circuit trees representing a design. A technology selection process in an electronic design automation-system comprises the steps of partitioning an original circuit design into a set of corresponding logic trees. Then, ordering the set of corresponding logic trees into an ordered linear list such that each tree-T that drives another ordered tree precedes the other ordered tree, and such that each ordered tree that drives the tree-T precedes the tree-T. Next, sweeping forward in the ordered linear list while computing a set of Pareto-optimal load/arrival curves for each of a plurality of net nodes that match a technology-library element. And, sweeping backward in the ordered linear list while using the set of Pareto-optimal load/arrival curves for each of the net nodes and a capacitive load to select a best one of the technology-library elements with a shortest signal arrival time. Wherein, only those net nodes that correspond to gate inputs are considered, and any capacitive loads are predetermined.

Abstract translation: 用于电子设计自动化系统的延迟优化技术映射过程选择库装置的最佳组合，以用于表示设计的电路树的向前和向后扫描。 电子设计自动化系统中的技术选择过程包括将原始电路设计分成一组对应的逻辑树的步骤。 然后，将一组对应的逻辑树排序成有序线性列表，使得驱动另一个有序树的每个树T先于另一个有序树，并且使得驱动树T的每个有序树先于树T。 接下来，在与技术库元素匹配的多个网络节点中的每一个计算一组帕累托优化加载/到达曲线时，在有序线性列表中向前扫描。 并且，在使用针对每个网络节点的一组帕累托优化加载/到达曲线和容性负载以最短的信号到达时间选择最佳的技术库元素之一时，在有序线性列表中向后扫描。 其中，仅考虑对应于栅极输入的那些网络节点，并且预定任何容性负载。

公开(公告)号：US09194040B2

公开(公告)日：2015-11-24

申请号：US13557348

申请日：2012-07-25

Applicant: David Knapp

Inventor： David Knapp

IPC: C23C16/00 ,  C07F15/00 ,  C23C16/18 ,  C07F15/04

CPC classification number: C23C16/18 ,  C07F15/04

Abstract: Provided are precursors and methods of using same to deposit film consisting essentially of nickel. Certain methods comprise providing a substrate surface; exposing the substrate surface to a vapor comprising a precursor having a structure represented, without limitation to specific orientation, by: wherein R1 and R2 are each independently H or any C1-C3 alkyl group, R4 is trimethylsilyl or C1-C3 alkyl, and L is any ligand that does not contain oxygen; and exposing the substrate to a reducing gas to provide a film consisting essentially of nickel on the substrate surface.

Abstract translation: 提供的是使用其沉积基本上由镍组成的膜的前体和方法。 某些方法包括提供基底表面; 将基板表面暴露于包含前体的蒸汽，所述前体具有但不限于特定取向的结构，其中R1和R2各自独立地为H或任何C1-C3烷基，R4为三甲基甲硅烷基或C1-C3烷基，L为 是不含氧的任何配体; 并将衬底暴露于还原气体，以在衬底表面上提供基本上由镍组成的膜。

公开(公告)号：US08859045B2

公开(公告)日：2014-10-14

申请号：US13555832

申请日：2012-07-23

Applicant: David Knapp ,  David Thompson

Inventor： David Knapp ,  David Thompson

IPC: C07F17/00 ,  C23C16/18 ,  C07F15/04

CPC classification number: C23C16/18 ,  C07F17/00

Abstract: Provided are precursors and methods of using same to deposit film consisting essentially of nickel. Certain methods comprise providing a substrate surface; exposing the substrate surface to a vapor comprising a precursor having a structure represented by formula (I): wherein R1 is t-butyl and each R2 is each independently any C1-C3 alkyl group; and exposing the substrate to a reducing gas to provide a film consisting essentially of nickel on the substrate surface.

Abstract translation: 提供的是使用其沉积基本上由镍组成的膜的前体和方法。 某些方法包括提供基底表面; 将基材表面暴露于包含具有由式（I）表示的结构的前体的蒸气：其中R 1是叔丁基，每个R 2各自独立地是任何C 1 -C 3烷基; 并将衬底暴露于还原气体，以在衬底表面上提供基本上由镍组成的膜。

公开(公告)号：US20070059338A1

公开(公告)日：2007-03-15

申请号：US11598903

申请日：2006-11-14

Applicant: David Knapp

Inventor： David Knapp

IPC: A61K38/48 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61K31/198 ,  A61K38/363 ,  A61K38/4833 ,  A61K45/06 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/622 ,  A61K2300/00

Abstract: A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.

Abstract translation: 提供一种治疗性医疗用品，其包括医疗制品，前体化合物和活化剂化合物。 医疗制品在给予患者时适应释放前体化合物和活化剂化合物，使得活化剂化合物与前体化合物相互作用并将前体化合物转化为活化形式用于局部递送。 前体和活化剂化合物对的具体实例包括：（a）亚硝基硫醇前体和一氧化氮供体，（b）纤溶酶原和纤溶酶原激活剂，和（c）纤维蛋白原和凝血酶。

公开(公告)号：US20060083328A1

公开(公告)日：2006-04-20

申请号：US10966254

申请日：2004-10-15

Applicant: Christopher Green ,  David Knapp ,  Horace Ho

Inventor： Christopher Green ,  David Knapp ,  Horace Ho

IPC: H04L27/20

CPC classification number: H04L25/03866 ,  H04L1/0061

Abstract: A communication system for transmitting and receiving a sequence of bits, and the methodology for transferring that sequence of bits are provided. The communication system includes a transmitting circuit and a receiving circuit. Within the transmitting circuit is a scrambler that comprises a shift register, an enable circuit, and an output circuit. The shift register temporarily stores n bits within the sequence of bits, and the enable circuit enables the shift register to store bits that arise only within the payload section of a frame. The output circuit includes a feedback, and several taps within the n stages to scramble logic values within the sequence of n bits output from the shift registers thus effectively preventing in most instances the sequence of bits from exceeding n number of the same logic value. Within the receiving circuit is a descrambler also having a shift register, an enable circuit, and an output circuit. The descrambler recompiles the scrambled data back to its original form. The scrambler is preferably placed before an encoder in the transmission path to minimize data dependent, low frequency jitter. The encoder is used to place a coding violation into the frame to signal the beginning of each frame, and to encode the parity with an offset against any DC accumulation of the coding violation and the scrambled payload to eliminate all DC accumulation (baseline wander) within each frame.

公开(公告)号：US20050094466A1

公开(公告)日：2005-05-05

申请号：US10979592

申请日：2004-11-01

Applicant: Daniel Archer ,  S. Luke ,  G. Mauger ,  Vincent Riot ,  David Knapp

Inventor： Daniel Archer ,  S. Luke ,  G. Mauger ,  Vincent Riot ,  David Knapp

IPC: G01T1/02 ,  G11C8/16 ,  G11C7/00

CPC classification number: G01T1/026 ,  G11C8/16 ,  G11C2029/5002

Abstract: A digital list mode multichannel analyzer (MCA) built around a programmable FPGA device for onboard data analysis and on-the-fly modification of system detection/operating parameters, and capable of collecting and processing data in very small time bins (

Abstract translation: 数字列表模式多通道分析仪（MCA）围绕可编程FPGA器件构建，用于板载数据分析和即时修改系统检测/操作参数，并能够在非常小的时间段（<1毫秒）收集和处理数据， 当用于直方图模式时，或在列表模式下用作列表模式MCA。

公开(公告)号：US20050062496A1

公开(公告)日：2005-03-24

申请号：US10665880

申请日：2003-09-19

Applicant: Alexander Gidon ,  David Knapp

Inventor： Alexander Gidon ,  David Knapp

IPC: G06F20060101 ,  G06F7/38 ,  G06F17/50

CPC classification number: G06F17/505

Abstract: A method for generating timing constraint systems, where the constrained object is a digital circuit., is provided, where the constraints are generated for the use of a digital logic optimization (synthesis) tool. The synthesis tool is used to optimize the circuit, under the applied constraints, so that the circuit exhibits certain desirable timing properties, while at the same time minimizing hardware cost and various other properties. The particular class of timing constraints generated by the disclosed invention is useful when the circuit is to be retimed after optimization. Typically, the joint use of the described invention and retiming results in improvements in the overall cost/performance tradeoff curve of the design. The invention comprises a method that comprises the following steps: (1) the flip-flops of the design are replaced with buffers having a negative delay whose magnitude is approximately the desired clock cycle time of the design; and (2) cycles in the design are broken using flip-flops having an infinite or quasi-infinite clock frequency. Following optimization by the synthesis tool, the temporary changes can be reverted, and retiming performed on the circuit.

Abstract translation: 提供了一种用于产生定时约束系统的方法，其中约束对象是数字电路，其中为使用数字逻辑优化（综合）工具生成约束。 该合成工具用于在施加的约束条件下优化电路，使得电路具有某些期望的时序特性，同时最小化硬件成本和各种其它特性。 当所述电路在优化之后被重新定时时，由所公开的发明产生的特定类别的时序约束是有用的。 通常，联合使用所描述的发明和重新定时导致设计的整体成本/性能折衷曲线的改进。 本发明包括一种方法，其包括以下步骤：（1）设计的触发器被具有负延迟的缓冲器替换，其幅度近似为设计的期望时钟周期时间; 并且（2）设计中的周期使用具有无限或准无限时钟频率的触发器来断开。 通过综合工具进行优化后，可以恢复临时更改，并对电路进行重新定时。