SUBSTITUTED QUINOLINES USEFUL AS KINASE INHIBITORS

    公开(公告)号:US20210087166A1

    公开(公告)日:2021-03-25

    申请号:US16970349

    申请日:2019-02-20

    申请人: Dawei Zhang

    发明人: Dawei Zhang

    IPC分类号: C07D401/12 A61P35/00

    摘要: The present invention is directed to novel quinoline-3-carbonitriles according to Formula I, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are useful for the treatment of protein kinases mediated diseases and conditions.

    METHOD AND APPARATUS FOR TREATING BLACK AND ODOROUS RIVER

    公开(公告)号:US20190127245A1

    公开(公告)日:2019-05-02

    申请号:US16095553

    申请日:2017-04-20

    发明人: Dawei Zhang

    IPC分类号: C02F1/52 C02F1/28 C02F11/12

    摘要: This disclosure discloses an apparatus of treating a black and odorous river, comprising a river bed sludge suction device, a container-type sand-stone refuse separation device, a container-type dehydration device, a container-type pulverization device, a storage container, a container-type drying device, a container-type carbonization device, a container-type flocculation device, a container-type precipitation device, a container-type activated coke filtration and adsorption device, a container-type power generation device, a container-type operation and control chamber, and a cleaning ship for river surface floats and river bank refuse. This disclosure discloses a method of treating a river using the apparatus described above where a biochar is produced from the separated, dehydrated and dried sludge. The biochar is then delivered back to the river bed to absorb nitrogen and phosphorus, cleaning the river water, followed by purification treatments on sewage discharged from the dehydration apparatus and discharging the treated sewage water back to the river.

    Active coke regeneration mixed vapor treatment method and apparatus

    公开(公告)号:US10207215B2

    公开(公告)日:2019-02-19

    申请号:US14354018

    申请日:2012-10-16

    发明人: Dawei Zhang

    摘要: There is provided an active coke regeneration mixed vapor treatment method. The method comprises the following process steps of: A) performing a first water condensation on a mixed vapor produced during an active coke regeneration process by spray water in a first condensation zone; B) performing a second water condensation on the mixed vapor that is after the first water condensation by spray water in a second condensation zone, to further condensate and purify the mixed vapor; C) eliminating moisture in a gas through mist elimination from the gas fraction in the mixed vapor that is after the second water condensation, and discharging the remaining gas from the upper of the second condensation zone; and, D) discharging active coke micro powder in the mixed vapor that is after the second water condensation, with condensation water. In the present invention, an apparatus for implementing the abovementioned method is also provided.

    Substituted heterocyclic compounds as kinases inhibitors and methods of use thereof
    45.
    发明授权
    Substituted heterocyclic compounds as kinases inhibitors and methods of use thereof 有权
    取代的杂环化合物作为激酶抑制剂及其使用方法

    公开(公告)号:US08748453B2

    公开(公告)日:2014-06-10

    申请号:US13380693

    申请日:2010-06-24

    申请人: Dawei Zhang

    发明人: Dawei Zhang

    摘要: The present invention is directed to novel quinolines and quniazolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof which are useful for the treatment of protein kinases mediated diseases and conditions. The compounds of this invention have a general Formula (I) wherein R1 to R11 and X are defined herein.

    摘要翻译: 本发明涉及可用于治疗蛋白激酶介导的疾病和病症的新颖的喹啉和它们的衍生物,药用盐,溶剂化物和水合物。 本发明的化合物具有通式(I),其中R 1至R 11和X如本文所定义。

    Urea Derivatives as Kinase Inhibitors
    47.
    发明申请
    Urea Derivatives as Kinase Inhibitors 审中-公开
    尿素衍生物作为激酶抑制剂

    公开(公告)号:US20120077851A1

    公开(公告)日:2012-03-29

    申请号:US13322374

    申请日:2010-06-08

    申请人: Dawei Zhang

    发明人: Dawei Zhang

    CPC分类号: C07D213/81 C07B59/002

    摘要: The present invention is directed to novel ureas, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof which are useful for the treatment of protein kinases mediated diseases and conditions. The compounds of this invention have a general Formula (I) wherein R, R1 to R10 are defined herein.

    摘要翻译: 本发明涉及可用于治疗蛋白激酶介导的疾病和病症的新型脲,其衍生物,药学上可接受的盐,溶剂合物和水合物。 本发明的化合物具有通式(I),其中R,R 1至R 10在本文中定义。

    Assembling unit for filtration and adsorption of waste and sewage water
    49.
    发明授权
    Assembling unit for filtration and adsorption of waste and sewage water 失效
    过滤和吸附废水和污水的组装单元

    公开(公告)号:US07699977B2

    公开(公告)日:2010-04-20

    申请号:US11575400

    申请日:2005-09-21

    IPC分类号: C02F1/28

    摘要: Wastewater and sewage filtering and adsorbing unit includes sewage reservoir, clean water reservoir, active coke powder storage, filtering and adsorbing tank, control cabinet, saturated active coke sludge settling tank, filtering and adsorbing material. The sewage reservoir and the clean water reservoir are on one side, and the filtering and adsorbing tank and the active coke powder storage are on other side. Active coke powder storage is above and connected to filtering and adsorbing tank by conduits; inlet pipes in rows and an outlet branch pipe are mounted into the filtering and adsorbing tank. Filtering and adsorbing material is active coke powder. The sewage reservoir is connected with the filtering and adsorbing tank. An active coke sludge discharge port and an active coke sludge conveyor, which are connected to the saturated active coke sludge settling tank by transporting pipelines, are at the bottom of the filtering and adsorbing tank.

    摘要翻译: 污水和污水过滤吸附装置包括污水库,清水库,活性焦粉储存,过滤吸附罐,控制柜,饱和活性焦渣沉淀池,过滤吸附材料。 污水池和净水池位于一侧,过滤吸附箱和活性焦炭粉存储在另一侧。 活性焦粉储存在上面,并通过管道与过滤和吸附罐连接; 排入口管和出口支管安装在过滤吸附罐中。 过滤吸附材料是活性焦炭粉。 污水池与过滤吸附罐连接。 主要焦炭污泥排放口和活性焦炭污泥输送机,通过运输管道与饱和活性焦炭污泥沉淀池连接,位于过滤和吸附罐的底部。

    METHOD FOR TREATING SATURATED ACTIVATED COKE
    50.
    发明申请
    METHOD FOR TREATING SATURATED ACTIVATED COKE 有权
    用于处理饱和活化焦糖的方法

    公开(公告)号:US20090197759A1

    公开(公告)日:2009-08-06

    申请号:US12301524

    申请日:2007-05-18

    申请人: Dawei Zhang

    发明人: Dawei Zhang

    IPC分类号: B01J20/34

    摘要: A method for treating saturated activated coke comprises the following steps: A) The saturated activated coke is subjected to a dehydration treatment so that the water content in the activated coke is ≦25%; B) The product obtained from step A is dried at a starting temperature of 120° C.-150° C.; C) The product obtained from step B is subjected to dry distillation and the condition of the dry distillation is that: by heating to a final temperature for the drying of 500° C.-600° C. at a speed of 4° C.-10° C./min and maintaining for 10-60 minutes, the organics adsorbed on the surface and in the pores of the activated coke is cracked, volatilized and carbonized; D) The product obtained from step C is activated and the activation condition is that: after heating to 800° C.-950° C. at 2° C.-8° C./min, a stream is supplied, wherein the weight ratio of the activated coke to the stream is 1:0.5-5 and the activation time is 0.5-2 h. The activated coke after several times of treatment can be used as the fuel.

    摘要翻译: 一种处理饱和活性焦炭的方法,包括以下步骤:A)对饱和活性焦炭进行脱水处理,使活性焦炭中的水分含量<25%; B)从步骤A得到的产物在起始温度为120℃-150℃下干燥。 C)将从步骤B得到的产物进行干馏,干馏条件为:以4℃的速度加热至500℃-600℃的最终温度。 -10℃/分钟,保持10-60分钟,吸附在表面和活性焦炭孔中的有机物被破裂,挥发和碳化; D)从步骤C获得的产物被活化,活化条件是:在2℃-8℃/分钟加热至800℃-950℃后,供应流,其中重量 活性焦炭与料流的比例为1:0.5-5,活化时间为0.5-2小时。 经过几次处理后的活化焦炭可用作燃料。