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    HETEROCYCLIC COMPOUNDS AND THEIR USES
    2.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
    杂环化合物及其用途

    公开(公告)号：US20130267526A1

    公开(公告)日：2013-10-10

    申请号：US13994332

    申请日：2011-12-16

    Applicant: Yi Chen ,  Timothy David Cushing ,  Benjamin Fisher ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Youngsook Shin

    Inventor： Yi Chen ,  Timothy David Cushing ,  Benjamin Fisher ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Youngsook Shin

    IPC: C07D471/04 ,  C07D473/00 ,  C07D403/12

    CPC classification number: C07D471/04 ,  C07D241/42 ,  C07D403/12 ,  C07D473/00

    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病（如急性骨髓性白血病AML）介导的，依赖于或与p110活性相关的癌症的方法，包括骨髓增生异常综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（CMD） L）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    Quinolines for the treatment of PI3K-δ mediated diseases
    3.
    发明授权
    Quinolines for the treatment of PI3K-δ mediated diseases 有权
    喹诺酮用于治疗PI3K-δ介导的疾病

    公开(公告)号：US08329910B2

    公开(公告)日：2012-12-11

    申请号：US13187188

    申请日：2011-07-20

    Applicant: Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    Inventor： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    IPC: C07D215/12

    CPC classification number: C07D401/12 ,  C07D401/14

    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including nut not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括不限于白血病的坚果，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    HETEROCYCLIC COMPOUNDS AND THEIR USES
    4.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
    杂环化合物及其用途

    公开(公告)号：US20110152277A1

    公开(公告)日：2011-06-23

    申请号：US13036236

    申请日：2011-02-28

    Applicant: Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    Inventor： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    IPC: A61K31/519 ,  C07D473/34 ,  A61K31/52 ,  A61P19/02 ,  A61P17/06 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04

    CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    Heterocyclic compounds and their uses
    7.
    发明授权
    Heterocyclic compounds and their uses 有权
    杂环化合物及其用途

    公开(公告)号：US08901135B2

    公开(公告)日：2014-12-02

    申请号：US13468234

    申请日：2012-05-10

    Applicant: Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    Inventor： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    IPC: C07D487/04 ,  C07D473/34 ,  C07D473/30

    CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34

    Abstract: Substituted bicyclic heteroaryls having the following formula where the variables are as defined herein, and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110□ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    Abstract translation: 具有下式的取代的双环杂芳基，其中变量如本文所定义，以及含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣， 包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血， 包括所有形式的超敏反应的过敏症状本发明还使得能够治疗依赖于p110□活性或与p110□活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic sy （MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞性白血病（T-ALL）B细胞急性淋巴细胞性白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和 实体肿瘤，如乳腺癌。

    HETEROCYCLIC COMPOUNDS AND THEIR USES
    10.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 有权
    杂环化合物及其用途

    公开(公告)号：US20110281897A1

    公开(公告)日：2011-11-17

    申请号：US13187135

    申请日：2011-07-20

    Applicant: Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    Inventor： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    IPC: A61K31/506 ,  A61P1/00 ,  A61P27/02 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  A61P25/00 ,  A61P37/08 ,  A61P17/06 ,  A61P17/00

    CPC classification number: C07D401/12 ,  C07D401/14

    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

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