公开(公告)号：US10155002B2

公开(公告)日：2018-12-18

申请号：US15346677

申请日：2016-11-08

Applicant: Epizyme, Inc.

Inventor： Kevin Wayne Kuntz ,  Richard Chesworth ,  Kenneth William Duncan ,  Heike Keilhack ,  Natalie Warholic ,  Christine Klaus ,  Sarah Kathleen Knutson ,  Timothy James Nelson Wigle ,  Masashi Seki ,  Syuji Shirotori ,  Satoshi Kawano

IPC: A61K31/5377 ,  C07D498/08 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D405/14 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US09855275B2

公开(公告)日：2018-01-02

申请号：US15598078

申请日：2017-05-17

Applicant: Epizyme, Inc.

Inventor： Kevin W. Kuntz ,  Richard Chesworth ,  Kenneth W. Duncan ,  Heike Keilhack ,  Natalie Warholic ,  Christine Klaus ,  Sarah K. Knutson ,  Timothy J. N. Wigle ,  Masashi Seki ,  Syuji Shirotori ,  Satoshi Kawano

IPC: A61K31/5377 ,  A61K31/444 ,  A61K31/506 ,  A61K31/4412 ,  A61K31/553 ,  A61K31/551 ,  C07D213/64 ,  C07D409/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D405/14 ,  C07D498/08 ,  A61K31/496 ,  A61K31/4709 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/4433 ,  A61K31/443 ,  C07D401/12

CPC classification number: A61K31/5377 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US09688665B2

公开(公告)日：2017-06-27

申请号：US14054646

申请日：2013-10-15

Applicant: Epizyme, Inc.

Inventor： Sarah K. Knutson ,  Natalie Warholic ,  Heike Keilhack

IPC: A61K31/5377 ,  C07D405/14 ,  C07D211/86 ,  C07D405/12 ,  C12Q1/68 ,  A61K31/4412 ,  A61K31/4545

CPC classification number: C07D405/14 ,  A61K31/4412 ,  A61K31/4545 ,  A61K31/5377 ,  C07D211/86 ,  C07D405/12 ,  C12Q1/6886

Abstract: The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20170119780A1

公开(公告)日：2017-05-04

申请号：US15346677

申请日：2016-11-08

Applicant: Epizyme, Inc.

Inventor： Kevin Wayne Kuntz ,  Richard Chesworth ,  Kenneth William Duncan ,  Heike Keilhack ,  Natalie Warholic ,  Christine Klaus ,  Sarah Kathleen Knutson ,  Timothy James Nelson Wigle ,  Masashi Seki ,  Syuji Shirotori ,  Satoshi Kawano

IPC: A61K31/5377 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/551 ,  A61K31/553 ,  A61K31/506 ,  A61K31/443 ,  A61K31/4709 ,  A61K31/4412 ,  A61K31/496

CPC classification number: A61K31/5377 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.