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公开(公告)号:US07538127B2
公开(公告)日:2009-05-26
申请号:US10544869
申请日:2004-02-12
申请人: Keith Biggadike , Philip Charles Box , Diane Mary Coe , Duncan Stuart Holmes , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
发明人: Keith Biggadike , Philip Charles Box , Diane Mary Coe , Duncan Stuart Holmes , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
IPC分类号: C07D213/65 , C07C217/08 , A61K31/44 , A61K31/18
CPC分类号: C07D213/65 , C07C217/28
摘要: A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).
摘要翻译: 式(I)化合物或其盐,溶剂合物或生理功能衍生物,其中:m为2至8的整数; n为2〜5的整数, 条件是m + n为4至10; R4和R5独立地选自氢和C1-4烷基,条件是R4和R5中的碳原子总数不大于4; R6和R7独立地选自氢和C1-4烷基,条件是R6和R7中的碳原子总数不大于4,Ar1是选自(a),(b),(c)中的基团, 和(d)。
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42.
公开(公告)号:US07135600B2
公开(公告)日:2006-11-14
申请号:US10467733
申请日:2002-02-11
申请人: Keith Biggadike , Diane Mary Coe , Stephen Barry Guntrip , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
发明人: Keith Biggadike , Diane Mary Coe , Stephen Barry Guntrip , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
IPC分类号: C07C39/12
CPC分类号: C07D295/26 , C07C311/27 , C07C311/29 , C07C311/58 , C07C2601/04 , C07C2601/14 , C07D295/13
摘要: The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译: 本发明涉及式(I)的新化合物,其制备方法,含有它们的药物组合物及其在治疗中的用途,特别是其在预防和治疗呼吸系统疾病中的用途。
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