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公开(公告)号：US07538127B2
公开(公告)日：2009-05-26
申请号：US10544869
申请日：2004-02-12
申请人： Keith Biggadike , Philip Charles Box , Diane Mary Coe , Duncan Stuart Holmes , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
发明人： Keith Biggadike , Philip Charles Box , Diane Mary Coe , Duncan Stuart Holmes , Brian Edgar Looker , Panayiotis Alexandrou Procopiou
IPC分类号： C07D213/65 , C07C217/08 , A61K31/44 , A61K31/18
CPC分类号： C07D213/65 , C07C217/28
摘要： A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).
摘要翻译： 式（I）化合物或其盐，溶剂合物或生理功能衍生物，其中：m为2至8的整数; n为2〜5的整数， 条件是m + n为4至10; R4和R5独立地选自氢和C1-4烷基，条件是R4和R5中的碳原子总数不大于4; R6和R7独立地选自氢和C1-4烷基，条件是R6和R7中的碳原子总数不大于4，Ar1是选自（a），（b），（c）中的基团， 和（d）。
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公开(公告)号：US07439393B2
公开(公告)日：2008-10-21
申请号：US11566346
申请日：2006-12-04
申请人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
发明人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
IPC分类号： C07C273/00 , C07C303/00 , C07C233/00 , A61K31/00
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations thereof, and methods for the treatment or prophylaxis of mammals by administering such compounds.
摘要翻译： 本发明涉及4 - {（1R）-2 - [（6- {2 - [（2,6-二氯苄基）氧基]乙氧基}己基）氨基] -1-羟乙基} -2-（羟甲基）苯酚; 及其盐和溶剂合物，包括药学上可接受的盐及其溶剂化物，以及其制剂，其组合，以及通过施用这些化合物治疗或预防哺乳动物的方法。
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公开(公告)号：US08198483B2
公开(公告)日：2012-06-12
申请号：US13165037
申请日：2011-06-21
申请人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
发明人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
IPC分类号： C07C273/00 , C07C233/00 , C07D413/04 , C07D319/08
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： (1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol and (5R)-3-(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one are claimed.
摘要翻译： （1R）-2 - [（6- {2 - [（2,6-二氯苄基）氧基]乙氧基}己基）氨基] -1-（2,2-二甲基-4H-1,3-苯并二恶英-6-基 ）乙醇和（5R）-3-（6- {2 - [（2,6-二氯苄基）氧基]乙氧基}己基）-5-（2,2-二甲基-4H-1,3-苯并二恶英-6-基 ）-1,3-恶唑烷-2-酮。
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公开(公告)号：US20110009631A1
公开(公告)日：2011-01-13
申请号：US12836025
申请日：2010-07-14
申请人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
发明人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
IPC分类号： C07D239/54 , C07C275/32 , C07D413/10 , C07C217/08 , C07C311/16 , C07D207/16 , C07D513/04 , C07D213/56
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases.
摘要翻译： 提供式（II）和（IV）的化合物，其可用作制备用于治疗呼吸系统疾病的化合物的中间体。
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公开(公告)号：US07442836B2
公开(公告)日：2008-10-28
申请号：US11426657
申请日：2006-06-27
申请人： Keith Biggadike , Diane Mary Coe , Dean David Edney , Stephen Barry Guntrip , Abigail Halton , Brian Edgar Looker , Michael John Monteith , Rebecca Jane Moore , Rajnikant Patel , Panayiotis Alexandrou Procopiou
发明人： Keith Biggadike , Diane Mary Coe , Dean David Edney , Stephen Barry Guntrip , Abigail Halton , Brian Edgar Looker , Michael John Monteith , Rebecca Jane Moore , Rajnikant Patel , Panayiotis Alexandrou Procopiou
IPC分类号： C07C303/00
CPC分类号： C07D295/26 , C07C311/27 , C07C311/29 , C07C311/58 , C07C2601/04 , C07C2601/14 , C07D295/13
摘要： The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译： 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。
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6.发明授权Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases 有权用于输送苯乙醇胺衍生物用于治疗呼吸系统疾病的吸入装置公开(公告)号：US07776895B2
公开(公告)日：2010-08-17
申请号：US12211322
申请日：2008-09-16
申请人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
发明人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
IPC分类号： A61K31/00
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations of the compound or a salt or solvate thereof, and methods for the treatment or prophylaxis of a clinical condition in a mammal by employing the inhalation devices.
摘要翻译： 本发明提供了包含4 - {（1R）-2 - [（6- {2 - [（2,6-二氯苄基）氧基]乙氧基}己基）氨基] -1-羟乙基} -2- （羟甲基）苯酚; 或其盐或溶剂化物，包含制剂及其化合物或其盐或溶剂合物的组合的吸入装置，以及通过使用吸入装置治疗或预防哺乳动物临床状况的方法。
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公开(公告)号：US07361787B2
公开(公告)日：2008-04-22
申请号：US10489569
申请日：2002-09-11
IPC分类号： C07C273/00 , C07C303/00 , C07C233/00 , A61K31/00
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases
摘要翻译： 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途
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公开(公告)号：US07271197B2
公开(公告)日：2007-09-18
申请号：US10512232
申请日：2003-04-24
IPC分类号： A61K31/166 , A61K31/17 , C07C233/65 , C07C62/04 , C07C275/46
CPC分类号： C07C275/32 , C07C217/60 , C07C233/25 , C07C235/42 , C07C255/54 , C07C279/18 , C07C307/10 , C07C311/08 , C07C311/29 , C07C317/22 , C07C2601/08 , C07C2601/14
摘要： The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译： 本发明涉及新的式（I）化合物或其盐，溶剂合物或生理功能衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其用于 预防和治疗呼吸系统疾病。
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公开(公告)号：US07982067B2
公开(公告)日：2011-07-19
申请号：US12836025
申请日：2010-07-14
申请人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
发明人： Philip Charles Box , Diane Mary Coe , Brian Edgar Looker , Inderjit Singh Mann , Panayiotis Alexandrou Procopiou
IPC分类号： C07C273/00 , C07C303/00 , C07C233/00 , C07D263/58
CPC分类号： C07D213/82 , C07C217/08 , C07C217/76 , C07C233/75 , C07C237/42 , C07C271/38 , C07C275/32 , C07C275/40 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/22 , C07C2601/02 , C07C2601/08 , C07D239/54 , C07D333/70 , C07D513/04
摘要： Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases.
摘要翻译： 提供式（II）和（IV）的化合物，其可用作制备用于治疗呼吸系统疾病的化合物的中间体。
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公开(公告)号：US07442837B2
公开(公告)日：2008-10-28
申请号：US11426661
申请日：2006-06-27
申请人： Keith Biggadike , Diane Mary Coe , Dean David Edney , Stephen Barry Guntrip , Abigail Halton , Brian Edgar Looker , Michael John Monteith , Rebecca Jane Moore , Rajnikant Patel , Panayiotis Alexandrou Procopiou
发明人： Keith Biggadike , Diane Mary Coe , Dean David Edney , Stephen Barry Guntrip , Abigail Halton , Brian Edgar Looker , Michael John Monteith , Rebecca Jane Moore , Rajnikant Patel , Panayiotis Alexandrou Procopiou
IPC分类号： C07C303/00
CPC分类号： C07D295/26 , C07C311/27 , C07C311/29 , C07C311/58 , C07C2601/04 , C07C2601/14 , C07D295/13
摘要： The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
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