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公开(公告)号：US10227308B2
公开(公告)日：2019-03-12
申请号：US15443894
申请日：2017-02-27
发明人： Simon M. Ametamey , Juergen Fingerle , Luca Gobbi , Uwe Grether , Ahmed Haider , Thomas Hartung , Linjing Mu , Leo Nicholls , Mark Rogers-Evans , Christoph Ullmer
IPC分类号： C07D231/40 , G01N33/566 , A61K51/04 , C07B59/00 , G01N33/60 , G01N33/94
摘要： The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
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公开(公告)号：US20180312528A1
公开(公告)日：2018-11-01
申请号：US16029228
申请日：2018-07-06
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Thomas Woltering , Christian Schnider , Roger Wermuth
IPC分类号： C07D513/04 , A61P25/28
CPC分类号： C07D513/04 , A61P25/28
摘要： The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US10047102B2
公开(公告)日：2018-08-14
申请号：US15314718
申请日：2015-07-21
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Thomas Woltering , Christian Schnider , Roger Wermuth
IPC分类号： C07D513/04 , A61P25/28
CPC分类号： C07D513/04 , A61P25/28
摘要： The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20180194779A1
公开(公告)日：2018-07-12
申请号：US15314718
申请日：2015-07-21
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Thomas Woltering , Christian Schnider , Roger Wermuth
IPC分类号： C07D513/04 , A61P25/28
CPC分类号： C07D513/04 , A61P25/28
摘要： The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US09920072B2
公开(公告)日：2018-03-20
申请号：US15522877
申请日：2015-10-30
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Didier Rombach , Thomas Woltering
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula (I), having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US09896438B2
公开(公告)日：2018-02-20
申请号：US15502044
申请日：2015-08-12
发明人： Lilli Anselm , Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Haap Wolfgang , Jens-Uwe Peters , Thomas Woltering , Ulrike Obst Sander , Mark Rogers-Evans
IPC分类号： C07D417/04 , C07D417/14 , C07D403/12
CPC分类号： C07D403/12
摘要： The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US09512132B2
公开(公告)日：2016-12-06
申请号：US14844991
申请日：2015-09-03
发明人： Uwe Grether , Atsushi Kimbara , Nettekoven Matthias , Ricklin Fabienne , Roever Stephan , Mark Rogers-Evans , Tanja Schulz-Gasch
IPC分类号： A61K31/437 , A61K31/519 , C07D471/04 , C07D487/04 , C07D473/04
CPC分类号： A61K31/519 , C07D471/04 , C07D473/04 , C07D487/04
摘要： The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 其中A1至A3和R1至R3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US09505762B2
公开(公告)日：2016-11-29
申请号：US14923177
申请日：2015-10-26
发明人： Stefanie Bendels , Uwe Grether , Atsushi Kimbara , Matthias Nettekoven , Stephan Roever , Mark Rogers-Evans , Tanja Schulz-Gasch
IPC分类号： C07D473/34 , C07D473/16 , C07D473/18 , C07D519/00
CPC分类号： C07D473/34 , C07D473/16 , C07D473/18 , C07D519/00
摘要： The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20160102105A1
公开(公告)日：2016-04-14
申请号：US14877250
申请日：2015-10-07
发明人： Bjoern Bartels , Philipp Cueni , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Walter Vifian , Thomas Woltering
IPC分类号： C07D513/04 , C07D519/00
CPC分类号： C07D513/04 , A61P25/28 , C07D519/00
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
摘要翻译： 本发明提供具有BACE1抑制活性的式I化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默氏病。
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![[1,2,3]triazolo[4,5-D]pyrimidine derivatives](/abs-image/US/2015/06/30/US09067943B2/abs.jpg.150x150.jpg)
公开(公告)号：US09067943B2
公开(公告)日：2015-06-30
申请号：US13680143
申请日：2012-11-19
发明人： Caterina Bissantz , Uwe Grether , Atsushi Kimbara , Matthias Nettekoven , Stephan Roever , Mark Rogers-Evans
IPC分类号： C07D413/00 , C07D487/04 , A61K9/00 , A61K47/10 , A61K47/12 , A61K9/20 , A61K9/48 , A61P9/10 , A61P3/10 , A61P27/06 , A61P29/00 , A61P1/16 , A61P13/12 , A61P9/02
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K47/10 , A61K47/12
摘要： The invention relates to a compound of formula (I) wherein A and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A和R 1至R 3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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