公开(公告)号：US12180196B2

公开(公告)日：2024-12-31

申请号：US17125648

申请日：2020-12-17

Applicant: HOFFMANN-LA ROCHE INC. ,  EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Inventor： Simon M. Ametamey ,  Luca Gobbi ,  Uwe Grether ,  Julian Kretz

IPC: C07D405/14 ,  C07D401/04

Abstract: The invention relates to a compound of formula (I) wherein A1 and R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US11608347B2

公开(公告)日：2023-03-21

申请号：US16922427

申请日：2020-07-07

Applicant: Hoffmann-La Roche Inc.

Inventor： Ann Petersen ,  Joerg Benz ,  Uwe Grether ,  Benoit Hornsperger ,  Buelent Kocer ,  Bernd Kuhn ,  Hans Richter ,  Satoshi Tsuchiya ,  Yangcheng Qiu ,  Rui Chen

IPC: C07D471/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US10450321B2

公开(公告)日：2019-10-22

申请号：US16228543

申请日：2018-12-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Luca Gobbi ,  Uwe Grether ,  Wolfgang Guba ,  Julian Kretz ,  Rainer E. Martin ,  Matthias Valentin Westphal ,  Adriaan Pieter Ijzerman

IPC: C07D487/04 ,  A61K31/519

Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US10227308B2

公开(公告)日：2019-03-12

申请号：US15443894

申请日：2017-02-27

Applicant: Hoffmann-La Roche Inc. ,  EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH ,  UNIVERSITÄT ZÜRICH

Inventor： Simon M. Ametamey ,  Juergen Fingerle ,  Luca Gobbi ,  Uwe Grether ,  Ahmed Haider ,  Thomas Hartung ,  Linjing Mu ,  Leo Nicholls ,  Mark Rogers-Evans ,  Christoph Ullmer

IPC: C07D231/40 ,  G01N33/566 ,  A61K51/04 ,  C07B59/00 ,  G01N33/60 ,  G01N33/94

Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.

公开(公告)号：US09512132B2

公开(公告)日：2016-12-06

申请号：US14844991

申请日：2015-09-03

Applicant: Hoffmann-La Roche Inc.

Inventor： Uwe Grether ,  Atsushi Kimbara ,  Nettekoven Matthias ,  Ricklin Fabienne ,  Roever Stephan ,  Mark Rogers-Evans ,  Tanja Schulz-Gasch

IPC: A61K31/437 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D473/04

CPC classification number: A61K31/519 ,  C07D471/04 ,  C07D473/04 ,  C07D487/04

Abstract: The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract translation: 其中A1至A3和R1至R3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。

公开(公告)号：US09505762B2

公开(公告)日：2016-11-29

申请号：US14923177

申请日：2015-10-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Stefanie Bendels ,  Uwe Grether ,  Atsushi Kimbara ,  Matthias Nettekoven ,  Stephan Roever ,  Mark Rogers-Evans ,  Tanja Schulz-Gasch

IPC: C07D473/34 ,  C07D473/16 ,  C07D473/18 ,  C07D519/00

CPC classification number: C07D473/34 ,  C07D473/16 ,  C07D473/18 ,  C07D519/00

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US09067943B2

公开(公告)日：2015-06-30

申请号：US13680143

申请日：2012-11-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Caterina Bissantz ,  Uwe Grether ,  Atsushi Kimbara ,  Matthias Nettekoven ,  Stephan Roever ,  Mark Rogers-Evans

IPC: C07D413/00 ,  C07D487/04 ,  A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K9/20 ,  A61K9/48 ,  A61P9/10 ,  A61P3/10 ,  A61P27/06 ,  A61P29/00 ,  A61P1/16 ,  A61P13/12 ,  A61P9/02

CPC classification number: C07D487/04 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K47/10 ,  A61K47/12

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract translation: 本发明涉及式（I）化合物，其中A和R 1至R 3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。

公开(公告)号：US20130116236A1

公开(公告)日：2013-05-09

申请号：US13669610

申请日：2012-11-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Jean-Michel Adam ,  Caterina Bissantz ,  Uwe Grether ,  Atsushi Kimbara ,  Matthias Nettekoven ,  Stephan Roever ,  Mark Rogers-Evans

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K9/0019 ,  A61K9/2054 ,  A61K9/4866 ,  A61K31/519 ,  A61K47/10 ,  C07D491/107

Abstract: The invention relates to a compound of formula (I) wherein A, R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract translation: 本发明涉及式（I）化合物，其中A，R 1和R 2如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。

公开(公告)号：US12071420B2

公开(公告)日：2024-08-27

申请号：US17125650

申请日：2020-12-17

Applicant: HOFFMANN-LA ROCHE INC. ,  ETH ZUERICH

Inventor： Luca Gobbi ,  Uwe Grether ,  Julian Kretz ,  Simon M. Ametamey

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The invention relates to a compound of formula (I)




wherein A1, A2, X and R1-R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US11999710B2

公开(公告)日：2024-06-04

申请号：US17125655

申请日：2020-12-17

Applicant: HOFFMANN-LA ROCHE INC. ,  ETH ZUERICH

Inventor： Simon M. Ametamey ,  Luca Gobbi ,  Uwe Grether ,  Julian Kretz ,  Dieter Muri ,  Ahmed Haider Wahauib

IPC: C07D401/04 ,  C07B59/00

CPC classification number: C07D401/04 ,  C07B59/002 ,  C07B2200/05

Abstract: The present invention relates to a compound of formula (I)




wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.