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44 条记录 (耗时 0.023 秒)

    Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones
    42.
    发明授权
    Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones 失效
    取代的环丁基-3,4-二酮的N-芳基甲基氨基衍生物

    公开(公告)号：US5780505A

    公开(公告)日：1998-07-14

    申请号：US889166

    申请日：1997-07-07

    申请人： Madelene M. Antane ,  David R. Herbst ,  Geraldine R. McFarlane ,  Eric G. Gundersen ,  Bradford H. Hirth ,  Dominick A. Quagliato ,  Russell F. Graceffa ,  John A. Butera

    发明人： Madelene M. Antane ,  David R. Herbst ,  Geraldine R. McFarlane ,  Eric G. Gundersen ,  Bradford H. Hirth ,  Dominick A. Quagliato ,  Russell F. Graceffa ,  John A. Butera

    IPC分类号： C07C225/20 ,  C07C233/41 ,  C07C255/58 ,  C07C271/24 ,  A61K31/275

    CPC分类号： C07C255/58 ,  C07C225/20 ,  C07C233/41 ,  C07C271/24 ,  C07C2101/04 ,  C07C2101/08

    摘要： The compounds of the formula: ##STR1## wherein R.sub.1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R.sub.7 and R.sub.8 are, independently, hydrogen or an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkoxycarbonyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is a phenyl group with either two or three substituents of the following formula: ##STR2## wherein the positions of substitution are R.sub.2,R.sub.3 -, R.sub.2,R.sub.4 -, R.sub.2,R.sub.5 -, R.sub.2,R.sub.6 -, R.sub.3,R.sub.4 -, R.sub.3,R.sub.5 -, and R.sub.2,R.sub.4,R.sub.6 - and R.sub.2 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.3 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.4 is methyl, fluoro, bromo, methoxy or cyano; R.sub.5 is methyl, fluoro, chloro, methoxy, cyano or trifluoromethyl; R.sub.6 is methyl, fluoro, chloro, or methoxy; or a pharmaceutically acceptable salt thereof, relax smooth muscles.

    摘要翻译： 下式的化合物：其中R 1是直链烷基，支链烷基，环烷基，羟基烷基，氟烷基或多氟烷基; R 7和R 8独立地是氢或选自甲酰基，烷酰基，烯酰基，烷氧基羰基，烷基磺酰基，芳酰基，芳基烯酰基，芳基磺酰基，芳基烷酰基或芳基烷基磺酰基的酰基取代基。 A是具有下式的两个或三个取代基的苯基：其中取代的位置是R2，R3-，R2，R4-，R2，R5-，R2，R6-，R3，R4-， R 3，R 5和R 2，R 4，R 6和R 2是甲基，乙基，氟，氯，甲氧基或三氟甲基; R3是甲基，乙基，氟，氯，甲氧基或三氟甲基; R4是甲基，氟，溴，甲氧基或氰基; R5是甲基，氟，氯，甲氧基，氰基或三氟甲基; R6是甲基，氟，氯或甲氧基; 或其药学上可接受的盐，使平滑肌松弛。

    Diaminocyclobutene-3,4-diones
    44.
    发明授权
    Diaminocyclobutene-3,4-diones 失效
    二氨基环丁烯-3,4-二酮

    公开(公告)号：US5512585A

    公开(公告)日：1996-04-30

    申请号：US459598

    申请日：1995-06-02

    申请人： Madelene M. Antane ,  John A. Butera ,  Bradford H. Hirth ,  Schuyler A. Antane

    发明人： Madelene M. Antane ,  John A. Butera ,  Bradford H. Hirth ,  Schuyler A. Antane

    IPC分类号： C07C233/41 ,  C07C255/60 ,  C07C271/28 ,  C07C311/08 ,  C07D213/75 ,  C07D217/02 ,  A61K31/44 ,  C07D213/36

    CPC分类号： C07D213/75 ,  C07C233/41 ,  C07C255/60 ,  C07C271/28 ,  C07C311/08 ,  C07D217/02 ,  C07C2101/04 ,  C07C2101/14 ,  C07C2102/42

    摘要： The compound of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are, independent from each other, hydrogen, C.sub.1-10 straight chain alkyl, C.sub.1-10 branched alkyl, or C.sub.3-10 cyclic or bicyclic alkyl;R.sub.3 is an acyl substituent selected from the group consisting of formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms;A is selected from the group consisting of: ##STR2## wherein: R.sub.4 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 perfluoroalkyl, C.sub.1-6 alkoxy, C.sub.1-6 perfluoroalkoxy, amino, C.sub.1-6 alkylamino, C.sub.2-12 dialkylamino, C.sub.1-6 alkylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, nitro, cyano or carboxyl;or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.

    摘要翻译： 下式的化合物：其中：R 1和R 2彼此独立地为氢，C 1-10直链烷基，C 1-10支链烷基或C 3-10环状或双环烷基; R3是选自甲酰基，2至7个碳原子的烷酰基，3至7个碳原子的烯酰基，1至7个碳原子的烷基磺酰基，7至12个碳原子的芳酰基，9至20个芳基烯酰基 6至12个碳原子的芳基磺酰基，8至12个碳原子的芳基烷酰基或7至12个碳原子的芳烷基磺酰基; A选自：其中：R4是氢，C1-6烷基，C1-6全氟烷基，C1-6烷氧基，C1-6全氟烷氧基，氨基，C1-6烷基氨基，C2-12二烷基氨基， 含有2-7个碳原子的C 1-6烷基磺酰氨基，烷基羧酰胺基，硝基，氰基或羧基; 或其药学上可接受的盐是平滑肌松弛剂。