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56 条记录 (耗时 0.028 秒)

    Amino acid derivatives
    42.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US6166072A

    公开(公告)日：2000-12-26

    申请号：US342492

    申请日：1999-06-29

    申请人： Stanley Charles Bell ,  Michael De Vivo ,  Allen Hopper ,  Methvin Isaac ,  Anne O'Brien ,  Vassil Ilya Ognyanov ,  Richard Schumacher

    发明人： Stanley Charles Bell ,  Michael De Vivo ,  Allen Hopper ,  Methvin Isaac ,  Anne O'Brien ,  Vassil Ilya Ognyanov ,  Richard Schumacher

    IPC分类号： C07C323/60 ,  A61K31/21

    CPC分类号： C07C323/60

    摘要： Described herein are compounds having the general formula: ##STR1## wherein: Ar.sup.1 and Ar.sup.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above;wherein any cycloalkyl or aryl substituent is linked to Ar.sup.1 or Ar.sup.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;R.sup.3 is selected from the group consisting of H and aryl, which may be substituted as for Ar.sup.1 ;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, alkyl, alkanoyl, benzoyl and benzyl.

    摘要翻译： 本文描述的是具有以下通式的化合物：其中：Ar 1和Ar 2是独立选择的芳基，任选地被选自烷基，环烷基，烷氧基，烷酰基，芳烷基，芳烷氧基，卤素，NO 2，Ph，CF 3， CN，OH，亚甲二氧基，亚乙二氧基，SO 2 NRR'，NRR'，CO 2 R（其中R和R'独立地选自H和烷基）和可如上所述被取代的第二芳基; 其中任何环烷基或芳基取代基通过可以是单键的桥连元件连接到Ar 1或Ar 2上，亚乙烯基，亚乙炔基，Z基，-Z-（CH 2）n - 基， - （CH 2） ）nZ-基或-Z-（CH2）nZ-基，其中Z表示O原子，S原子，NH基或N-烷基，n是1至4的整数; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; R 3选自H和芳基，其可以被取代为Ar 1; R 4和R 5独立地选自H，烷基，烷酰基，苯甲酰基和苄基。

    Signal sensing device and circuit boards
    43.
    发明授权
    Signal sensing device and circuit boards 有权
    信号传感装置和电路板

    公开(公告)号：US09234915B2

    公开(公告)日：2016-01-12

    申请号：US13387671

    申请日：2009-12-02

    申请人： Letha Rousseau ,  Richard Schumacher

    发明人： Letha Rousseau ,  Richard Schumacher

    IPC分类号： G01R31/28 ,  G01R1/067

    CPC分类号： G01R1/06772 ,  G01R31/2822

    摘要： Apparatus are provided for use in testing circuit boards. A signal sensing device includes one or more probes. Each probe includes a length of rigid coaxial conductor configured to define a sensing pin at one end. A circuit board defines a number of through vias lined in metal and configured to receive the sensing pin of a corresponding probe. The signal sensing device also includes a ground pin. Electrical pathways extending away from adjacent pairs of the through vias can be tested for electrical impedance and other signal propagating characteristics by way of the signal sensing device.

    摘要翻译： 提供了用于测试电路板的设备。 信号感测装置包括一个或多个探针。 每个探针包括一长度的刚性同轴导体，其被配置为在一端限定感测针。 电路板定义了金属内衬的多个贯通孔，并配置为接收相应探针的感测针。 信号感测装置还包括接地引脚。 可以通过信号感测装置测试从相邻的通孔对延伸的电路，以获得电阻抗和其他信号传播特性。

    SIGNAL SENSING DEVICE AND CIRCUIT BOARDS
    45.
    发明申请
    SIGNAL SENSING DEVICE AND CIRCUIT BOARDS 有权
    信号感应器和电路板

    公开(公告)号：US20120119779A1

    公开(公告)日：2012-05-17

    申请号：US13387671

    申请日：2009-12-02

    申请人： Letha Rousseau ,  Richard Schumacher

    发明人： Letha Rousseau ,  Richard Schumacher

    IPC分类号： G01R31/28

    CPC分类号： G01R1/06772 ,  G01R31/2822

    摘要： Apparatus are provided for use in testing circuit boards. A signal sensing device includes one or more probes. Each probe includes a length of rigid coaxial conductor configured to define a sensing pin at one end. A circuit board defines a number of through vias lined in metal and configured to receive the sensing pin of a corresponding probe. The signal sensing device also includes a ground pin. Electrical pathways extending away from adjacent pairs of the through vias can be tested for electrical impedance and other signal propagating characteristics by way of the signal sensing device.

    摘要翻译： 提供了用于测试电路板的设备。 信号感测装置包括一个或多个探针。 每个探针包括一长度的刚性同轴导体，其被配置为在一端限定感测针。 电路板定义了金属内衬的多个贯通孔，并配置为接收相应探针的感测针。 信号感测装置还包括接地引脚。 可以通过信号传感装置测试从相邻的通孔对延伸的电路，以获得电阻抗和其他信号传播特性。

    Nicotinic alpha-7 receptor ligands and preparation and uses thereof
    48.
    发明授权
    Nicotinic alpha-7 receptor ligands and preparation and uses thereof 失效
    烟碱型α-7受体配体及其制备及应用

    公开(公告)号：US07625924B2

    公开(公告)日：2009-12-01

    申请号：US11312831

    申请日：2005-12-21

    申请人： Truc Minh Nguyen ,  Wenge Xie ,  Richard Schumacher ,  Brian Herbert ,  Ashok Tehim

    发明人： Truc Minh Nguyen ,  Wenge Xie ,  Richard Schumacher ,  Brian Herbert ,  Ashok Tehim

    IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D513/02 ,  C07D515/02

    CPC分类号： C07D453/02

    摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

    摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型配体的新型化合物，制备此类化合物的方法，含有这些化合物的组合物及其使用方法。

    Electronic component cooling
    50.
    发明申请
    Electronic component cooling 审中-公开
    电子元件冷却

    公开(公告)号：US20080173427A1

    公开(公告)日：2008-07-24

    申请号：US11656776

    申请日：2007-01-23

    申请人： Richard Schumacher

    发明人： Richard Schumacher

    IPC分类号： F28D15/00 ,  H05K7/20

    CPC分类号： H05K7/20609

    摘要： An electronic assembly incorporates a sealed chamber that is filled with a first cooling fluid. A second cooling fluid that does not contact the first cooling fluid is circulated so as to remove heat from the first cooling fluid. The second cooling fluid is transported to an external heat removal system. Fluid circulation apparatus circulates the first cooling fluid within the chamber and facilitates heat transfer from components in the chamber. Optionally, the second cooling fluid may provide power to circulate the first cooling fluid.

    摘要翻译： 电子组件包括填充有第一冷却流体的密封室。 不与第一冷却流体接触的第二冷却流体循环，从而从第一冷却流体中除去热量。 第二冷却流体输送到外部除热系统。 流体循环装置使腔室内的第一冷却流体循环并且促进从室中的部件的热传递。 可选地，第二冷却流体可以提供使第一冷却流体循环的动力。