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72 条记录 (耗时 0.046 秒)

    System and method to effect the mitral valve annulus of a heart
    41.
    发明授权
    System and method to effect the mitral valve annulus of a heart 有权
    影响心脏二尖瓣环的系统和方法

    公开(公告)号：US06964683B2

    公开(公告)日：2005-11-15

    申请号：US10798728

    申请日：2004-03-10

    申请人： Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    发明人： Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451

    摘要： An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.

    摘要翻译： 用于实现二尖瓣环的状态的组件包括二尖瓣治疗装置，由装置承载的联接结构，导管，第二联接结构和锁定构件。 为了植入装置，装置首先通过联接结构和锁定构件可释放地锁定到推动构件。 当装置定位在邻近二尖瓣环并展开的冠状窦内时，联接结构可以通过释放锁定构件而相互释放。

    Device, assembly and method for mitral valve repair
    42.
    发明授权
    Device, assembly and method for mitral valve repair 有权
    二尖瓣修复的装置，装配和方法

    公开(公告)号：US06797001B2

    公开(公告)日：2004-09-28

    申请号：US10095507

    申请日：2002-03-11

    申请人： Mark L. Mathis ,  Gregory D. Nieminen

    发明人： Mark L. Mathis ,  Gregory D. Nieminen

    IPC分类号： A61F206

    CPC分类号： A61F2/2451 ,  Y10S623/904

    摘要： A mitral valve therapy device effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus to substantially straighten and increase the radius of curvature of the mitral valve annulus.

    摘要翻译： 二尖瓣治疗装置影响心脏二尖瓣环的状况。 该装置包括细长构件，其尺寸设置为放置在邻近二尖瓣环的心脏的冠状窦内。 细长构件在以第一取向放置在心脏中时是柔性的，以将装置定位在邻近二尖瓣环的冠状窦中，并且在将装置定位在与二尖瓣邻近的冠状窦内的第二取向时相对不灵活 环形件以基本上拉直并增加二尖瓣环的曲率半径。

    Device and Method for Modifying the Shape of a Body Organ
    45.
    发明申请
    Device and Method for Modifying the Shape of a Body Organ 审中-公开
    修饰身体器官形状的装置和方法

    公开(公告)号：US20120197389A1

    公开(公告)日：2012-08-02

    申请号：US13443709

    申请日：2012-04-10

    申请人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

    发明人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451 ,  A61F2250/001 ,  A61F2250/0059

    摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

    摘要翻译： 血管内支持装置包括支撑件或再生线，近端锚和远端锚。 支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。 锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。 该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。 锚固件可以锁定到位以将支撑件固定在容器内。

    Devices and Methods for Reducing Mitral Valve Regurgitation
    46.
    发明申请
    Devices and Methods for Reducing Mitral Valve Regurgitation 审中-公开
    减少二尖瓣反流的装置和方法

    公开(公告)号：US20120123532A1

    公开(公告)日：2012-05-17

    申请号：US13359307

    申请日：2012-01-26

    申请人： Mark L. Mathis

    发明人： Mark L. Mathis

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451 ,  A61F2210/0023

    摘要： A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

    摘要翻译： 二尖瓣环重塑装置至少包括由具有特征温度Af的生物相容性形状记忆合金SMA形成的部分，其优选低于体温。 该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。 当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。 当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。 当器件在冠状窦内时，SMA的应变可以变化。

    Device and Method for Modifying the Shape of a Body Organ
    47.
    发明申请
    Device and Method for Modifying the Shape of a Body Organ 审中-公开
    修饰身体器官形状的装置和方法

    公开(公告)号：US20110106117A1

    公开(公告)日：2011-05-05

    申请号：US13004239

    申请日：2011-01-11

    申请人： Mark L. Mathis ,  David Reuter ,  Lucas Gordon ,  Cruz Beeson ,  Garrett Beget ,  Frederick Stewart

    发明人： Mark L. Mathis ,  David Reuter ,  Lucas Gordon ,  Cruz Beeson ,  Garrett Beget ,  Frederick Stewart

    IPC分类号： A61B17/08

    CPC分类号： A61F2/2451 ,  A61B2017/00243

    摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.

    摘要翻译： 组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。 在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。 本发明也是改变目标组织形状的方法。 该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

    Percutaneous mitral valve annuloplasty delivery system
    48.
    发明授权
    Percutaneous mitral valve annuloplasty delivery system 有权
    经皮二尖瓣瓣环成形术输送系统

    公开(公告)号：US07837729B2

    公开(公告)日：2010-11-23

    申请号：US10946332

    申请日：2004-09-20

    申请人： Lucas S. Gordon ,  Mark L. Mathis ,  Gregory Nieminen ,  Leonard Kowalsky ,  Ryan Braxtan ,  Brian J. Doll

    发明人： Lucas S. Gordon ,  Mark L. Mathis ,  Gregory Nieminen ,  Leonard Kowalsky ,  Ryan Braxtan ,  Brian J. Doll

    IPC分类号： A61F2/06

    CPC分类号： A61B17/3468 ,  A61F2/2451 ,  A61F2/95 ,  A61F2002/9511 ,  A61F2002/9517

    摘要： The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.

    摘要翻译： 本发明是一种组织成形系统，包括具有可扩张锚和锁的组织成形装置; 输送导管; 输送机构，其适于经由输送导管将患者外部的组织成形装置输送到患者体内的内腔内的目标部位; 以及致动器，其适于将致动力传递到所述锁以将所述锚固件锁定在扩展构型中。 本发明也是适于在患者的内腔内的目标部位经皮输送和部署组织整形装置的系统。 该系统包括：手柄; 由手柄支撑并适于经由输送导管将组织成形装置从患者外部递送到治疗部位的递送机构; 以及致动器，其由所述手柄支撑并且适于递送致动力以将所述组织整形装置的锚固件以扩展构型锁定。

    Device, assembly and method for mitral valve repair
    49.
    发明授权
    Device, assembly and method for mitral valve repair 有权
    二尖瓣修复的装置，装配和方法

    公开(公告)号：US07364588B2

    公开(公告)日：2008-04-29

    申请号：US10912735

    申请日：2004-08-04

    申请人： Mark L. Mathis ,  Gregory Nieminen

    发明人： Mark L. Mathis ,  Gregory Nieminen

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2451 ,  Y10S623/904

    摘要： A mitral valve therapy device effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus to substantially straighten and increase the radius of curvature of the mitral valve annulus.

    摘要翻译： 二尖瓣治疗装置影响心脏二尖瓣环的状况。 该装置包括细长构件，其尺寸设置为放置在邻近二尖瓣环的心脏的冠状窦内。 细长构件在以第一取向放置在心脏中时是柔性的，以将装置定位在邻近二尖瓣环的冠状窦中，并且在将装置定位在与二尖瓣邻近的冠状窦内的第二取向时相对不灵活 环形件以基本上拉直并增加二尖瓣环的曲率半径。