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公开(公告)号：US20130072686A1
公开(公告)日：2013-03-21
申请号：US13620391
申请日：2012-09-14
申请人： Jean-Jacques Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
发明人： Jean-Jacques Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC分类号： C07D491/20 , C07D491/22
CPC分类号： C07D491/20 , C07D405/04
摘要： This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及制备某些螺 - 羟吲哚衍生物的方法，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。
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公开(公告)号：US06436915B1
公开(公告)日：2002-08-20
申请号：US09747563
申请日：2000-12-22
IPC分类号： A61K31415
CPC分类号： C07D231/38 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/454 , A61K31/53 , A61K31/5377 , C07D231/46 , C07D231/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
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43.发明授权Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents 有权螺 - 羟吲哚化合物的对映异构体及其用作治疗剂公开(公告)号：US08883840B2
公开(公告)日：2014-11-11
申请号：US13619915
申请日：2012-09-14
IPC分类号： A01N43/38 , A61K31/40 , A61K31/407 , C07D491/22 , C07D491/20
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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44.发明授权Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents 有权螺 - 羟吲哚化合物的对映异构体及其用作治疗剂公开(公告)号：US08450358B2
公开(公告)日：2013-05-28
申请号：US12825168
申请日：2010-06-28
IPC分类号： A01N43/38 , A61K31/40 , C07D491/00 , C07D495/00
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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公开(公告)号：US20130072537A1
公开(公告)日：2013-03-21
申请号：US13619915
申请日：2012-09-14
IPC分类号： C07D491/20 , A61K31/407
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
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46.发明申请ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 有权螺旋体化合物的使用者及其作为治疗剂的用途公开(公告)号：US20100331386A1
公开(公告)日：2010-12-30
申请号：US12825168
申请日：2010-06-28
IPC分类号： A61K31/407 , C07D491/20 , A61P29/00 , A61P25/24 , A61P9/00 , A61P11/00 , A61P25/00 , A61P1/04
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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