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101 条记录 (耗时 0.038 秒)

    Osmotic device for delayed delivery of agent
    42.
    发明授权
    Osmotic device for delayed delivery of agent 失效
    用于延迟递送药剂的渗透装置

    公开(公告)号：US5443459A

    公开(公告)日：1995-08-22

    申请号：US109120

    申请日：1993-08-19

    申请人： Patrick S. L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    发明人： Patrick S. L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.

    摘要翻译： 本发明涉及用于将活性剂最初延迟递送到使用的流体环境的流体吸入分配装置以及使用分配装置的方法。 所述分配器包括壳体，所述壳体具有彼此可逆地滑动伸缩布置的第一壁部分和第二壁部分，所述壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 隔室中的至少一种活性剂制剂; 以及膨胀装置和隔室中的推板，用于在暴露于使用环境之后将壳体的第一和第二壁部分分开以将活性剂制剂暴露于使用环境。

    Osmotically driven syringe
    45.
    发明授权
    Osmotically driven syringe 失效
    渗透式注射器

    公开(公告)号：US5030216A

    公开(公告)日：1991-07-09

    申请号：US451476

    申请日：1989-12-15

    申请人： Felix Theeuwes ,  Patrick S. L. Wong

    发明人： Felix Theeuwes ,  Patrick S. L. Wong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M5/145

    CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M5/145 ,  A61M2005/14513

    摘要： An implantable osmotically driven syringe is disclosed which can be used to deliver a beneficial agent, such as a drug, at a predetermined rate over an extended period of time. A movable piston divides the syringe into a beneficial agent-containing compartment and a driving compartment. The piston is movable into a position wherein the driving compartment has a volume of essentially zero. The syringe is driven by an osmotic engine which has a shaped wall surrounding, and in contact with, an osmotic solute. The wall is comprised of a semipermeable and/or microporous material which is permeable to the external fluid (e.g., water) but is impermeable to the solute. The engine also has a passageway forming a fluid flow path between the osmotic solute and the driving compartment. A portion of the wall is exposed to a fluid-containing external environment. At least about 30% of the wall which contacts the solute also is exposed to the fluid in the external environment. In operation, water from the external environment is imbided through the semipermeable wall forming a solution of the solvent in the osmotic engine. As fresh incoming fluid from the external environment is imbided by the engine, the solution is pumped through the passageway into the driving compartment. The pumping action drives the piston which causes the beneficial agent to be delivered by the syringe.

    摘要翻译： 公开了一种可植入的渗透驱动的注射器，其可以用于在延长的时间段内以预定的速率递送诸如药物的有益剂。 可移动活塞将注射器分成含有益剂的隔室和驱动室。 活塞可移动到驱动室具有基本为零的体积的位置。 注射器由渗透引擎驱动，渗透引擎具有围绕并与渗透性溶质接触的成形壁。 该壁由半透性和/或微孔材料构成，其可渗透外部流体（例如水），但对溶质是不可渗透的。 发动机还具有在渗透性溶质和驱动室之间形成流体流路的通路。 壁的一部分暴露于含流体的外部环境中。 接触溶质的壁的至少约30％也暴露于外部环境中的流体。 在操作中，来自外部环境的水通过形成溶剂在渗透引擎中的溶液的半透壁渗透。 当来自外部环境的新鲜流体被发动机吸入时，溶液被泵送通过通道进入驱动室。 抽吸作用驱动活塞，其导致有益剂被注射器递送。