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83 条记录 (耗时 0.043 秒)

    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
    45.
    发明授权
    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure 失效
    抑制途径闭合抑制透皮药物通量降低的方法

    公开(公告)号：US07438926B2

    公开(公告)日：2008-10-21

    申请号：US09950436

    申请日：2001-09-08

    申请人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    发明人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    IPC分类号： A61F13/00

    CPC分类号： A61K9/703 ,  A61K9/0021 ,  A61K9/7084 ,  Y10S514/947

    摘要： This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).

    摘要翻译： 本发明涉及一种用于抑制在延长的时间段内经皮递送或取样的试剂的经皮通量降低的方法，其中所述递送或取样涉及破坏至少皮肤的角质层以形成穿过 代理人通过。 期望的结果是通过将试剂与至少一种抗愈合剂的量共同递送或共同取样而实现的，其中抗愈合剂的量有效抑制试剂透皮通量的降低， 药剂的递送或取样在基本相同的条件下进行，除了不存在抗愈合剂之外。