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42 条记录 (耗时 0.038 秒)

    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    41.
    发明申请
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 有权
    化合物及其调节方法及其适应症

    公开(公告)号：US20090286783A1

    公开(公告)日：2009-11-19

    申请号：US12467208

    申请日：2009-05-15

    申请人： Prabha N. Ibrahim ,  Wayne Spevak ,  Hanna Cho ,  Songyuan Shi

    发明人： Prabha N. Ibrahim ,  Wayne Spevak ,  Hanna Cho ,  Songyuan Shi

    IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519 ,  C07D413/02

    CPC分类号： C07D487/04

    摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof derivatives thereof, forms thereof are active on at least one Raf protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Raf protein kinases, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, cholangiocarcinoma, pain or polycystic kidney disease.

    摘要翻译： 其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。 在某些方面和实施方案中，所述的化合物或其盐，其制剂，其衍生物，其衍生物，其形式在至少一种Raf蛋白激酶上具有活性。 还描述了其用于治疗疾病和病症的方法，包括与Raf蛋白激酶（包括黑素瘤，结肠直肠癌，甲状腺癌，卵巢癌，胆管癌，疼痛或多囊肾病）的活动相关的疾病和病症。