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    Regimens of tafenoquine for prevention of malaria in malaria-naïve subjects
    4.
    发明授权
    Regimens of tafenoquine for prevention of malaria in malaria-naïve subjects 有权

    公开(公告)号：US11744828B2

    公开(公告)日：2023-09-05

    申请号：US17145530

    申请日：2021-01-11

    Applicant: 60 Degrees Pharmaceuticals LLC

    Inventor： Geoffrey S. Dow ,  Bryan L. Smith ,  John P. Jones ,  Moshe Shmuklarsky ,  Budda Balasubrahmanyam

    IPC: A61K31/4706 ,  C07D215/40 ,  A61P33/06

    CPC classification number: A61K31/4706 ,  A61P33/06 ,  C07D215/40 ,  Y02A50/30

    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects.

    Novel Regimens of Tafenoquine for Prevention of Malaria in Malaria-Naive Subjects
    6.
    发明申请
    Novel Regimens of Tafenoquine for Prevention of Malaria in Malaria-Naive Subjects 审中-公开

    公开(公告)号：US20170360768A1

    公开(公告)日：2017-12-21

    申请号：US15532280

    申请日：2015-12-02

    Applicant: 60 Degrees Pharmaceuticals LLC

    Inventor： Bryan L Smith ,  John Paul Jones ,  Moshe Shmuklarsky ,  Budda Balasubrahmanyam

    IPC: A61K31/4706

    CPC classification number: A61K31/4706 ,  A61P33/06 ,  C07D215/40 ,  Y02A50/411

    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects.

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