公开(公告)号：US09193728B2

公开(公告)日：2015-11-24

申请号：US13579900

申请日：2011-02-18

Applicant: Sarvajit Chakravarty ,  Barry Patrick Hart

Inventor： Sarvajit Chakravarty ,  Barry Patrick Hart ,  Rajendra Parasmal Jain

IPC: A61K31/4375 ,  C07D471/14 ,  C07D471/16 ,  C07D471/18 ,  C07D471/22 ,  C07D498/16 ,  C07D513/16 ,  C07D498/14 ,  C07D513/00

CPC classification number: C07D471/14 ,  C07D471/16 ,  C07D471/18 ,  C07D471/22 ,  C07D498/14 ,  C07D498/16 ,  C07D513/00 ,  C07D513/16

Abstract: This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract translation: 本公开涉及稠合的四环吡啶并[4,3-b]吲哚和吡啶并[3,4-b]吲哚。 还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

公开(公告)号：US20130137705A1

公开(公告)日：2013-05-30

申请号：US13498099

申请日：2010-09-23

Applicant: Sarvajit Chakravarty

Inventor： Rajendra Parasmal Jain ,  Sarvajit Chakravarty

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.