公开(公告)号：US20230337537A1

公开(公告)日：2023-10-19

申请号：US17912871

申请日：2021-03-19

申请人： Merck Patent GmbH

发明人： Amir Hossain PARHAM

IPC分类号： H10K85/60 ,  C09K11/06 ,  C07F5/02 ,  C07D487/16 ,  C07D487/06 ,  C07D513/16 ,  C07D498/16 ,  C07D498/06 ,  C07D513/06

CPC分类号： H10K85/658 ,  C07D487/06 ,  C07D487/16 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  C07D513/16 ,  C07F5/027 ,  C09K11/06 ,  H10K85/657 ,  H10K85/6572 ,  C09K2211/1018 ,  H10K50/121

摘要： Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic device.

公开(公告)号：US20230192719A1

公开(公告)日：2023-06-22

申请号：US18065868

申请日：2022-12-14

申请人： CANON KABUSHIKI KAISHA

发明人： HIROKAZU MIYASHITA ,  JUN KAMATANI ,  NAOKI YAMADA ,  HIRONOBU IWAWAKI ,  HIROKI OHRUI ,  YOSUKE NISHIDE

IPC分类号： C07D498/06 ,  H10K85/60 ,  C07D513/06 ,  C07D519/00 ,  C07D471/06 ,  C07D498/16 ,  C07D513/16 ,  C07D471/16 ,  C07F7/08 ,  H10K85/40 ,  H10K85/30 ,  H10K50/80

CPC分类号： C07D498/06 ,  H01L51/0071 ,  H01L51/0073 ,  C07D513/06 ,  C07D519/00 ,  C07D471/06 ,  H01L51/0072 ,  H01L51/0067 ,  H01L51/0074 ,  C07D498/16 ,  C07D513/16 ,  C07D471/16 ,  C07F7/0812 ,  H01L51/0094 ,  H01L51/0064 ,  H01L51/007 ,  H01L51/0085 ,  H01L51/52 ,  C07B2200/05

摘要： An organic compound represented by the formula [1]:




R1 to R19 are independently selected from the group consisting of a hydrogen atom, a deuterium atom, a halogen atom, and a substituent, and R9 and R19 are optionally bonded together. When R9 and R19 are bonded together, the bonding is selected from the group consisting of direct bonding, bonding via an oxygen atom or a sulfur atom, and bonding via CR20R21. R20 and R21 independently have the same meaning as R1 to R19. X1 and X2 independently denote an oxygen atom, a sulfur atom, CR20R21, or a single bond. Ar denotes an aromatic hydrocarbon group or a heterocyclic group, n denotes an integer in the range of 0 to 2, and m denotes an integer in the range of 1 to 4. When n is 0, any one of R1 to R8 is directly bonded to any one of R9 to R19.

公开(公告)号：US11649249B2

公开(公告)日：2023-05-16

申请号：US16606784

申请日：2018-04-24

申请人： Merck Patent GmbH

发明人： Amir Parham ,  Jonas Kroeber ,  Dominik Joosten ,  Aurélie Ludemann ,  Tobias Grossmann

IPC分类号： C07D513/16 ,  C07D498/16 ,  C07D519/00 ,  C07D498/04 ,  C07D513/04 ,  H01L51/00

CPC分类号： C07D513/16 ,  C07D498/04 ,  C07D498/16 ,  C07D513/04 ,  C07D519/00 ,  H01L51/0067 ,  H01L51/0068 ,  H01L51/0072 ,  H01L51/0073

摘要： The present application relates to bridged triarylamines conforming to a defined formula. These compounds are suitable for use in electronic devices. The present application further relates to processes for preparing the compounds, and to electronic devices comprising the compounds.

公开(公告)号：US09808466B2

公开(公告)日：2017-11-07

申请号：US15006755

申请日：2016-01-26

申请人： Fundación Centro Nacional de Investigaciones Oncologicas Carlos III

发明人： Joaquín Pastor Fernández ,  Rosa María Álvarez Escobar ,  Rosario Concepción Riesco Fagundo ,  Ana Belén García García ,  Antonio Rodríguez Hergueta ,  Jose Ignacio Martín Hernando ,  Carmen Blanco Aparicio ,  David Álvaro Cebrián Muñoz

IPC分类号： A61K45/06 ,  A61K31/5383 ,  C07D513/16 ,  C07D513/22 ,  C07D515/22 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/4745 ,  A61K31/5025 ,  A61K31/519

CPC分类号： A61K31/5383 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/4745 ,  A61K31/5025 ,  A61K31/519 ,  A61K45/06 ,  C07D513/16 ,  C07D513/22 ,  C07D515/22 ,  A61K2300/00

摘要： There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.

公开(公告)号：US20160024113A1

公开(公告)日：2016-01-28

申请号：US14776798

申请日：2014-03-14

申请人： ONCODESIGN S.A.

发明人： Petra Marcella, Francoise BLOM ,  Jan Marie, Cyriel, Jozef HOFLACK ,  Pascal Andre, Rene BENDERITTER

IPC分类号： C07D498/16 ,  C07D513/16

CPC分类号： C07D498/16 ,  A61K31/5025 ,  A61K31/519 ,  C07D487/18 ,  C07D487/22 ,  C07D491/18 ,  C07D498/18 ,  C07D498/22 ,  C07D513/16 ,  C07D513/18 ,  C07D515/18

摘要： The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of SIK kinase, more in particular SIK1, SIK2 and/or SIK3 and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of SIK-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

摘要翻译： 本发明涉及大环化合物和含有所述化合物作为激酶抑制剂的组合物，特别是作为SIK激酶抑制剂，特别是SIK1，SIK2和/或SIK3和/或其突变体的抑制剂，用于诊断，预防和/ 或治疗SIK-激酶相关疾病。 此外，本发明提供使用所述化合物的方法，例如作为药物或诊断剂。

公开(公告)号：US20140256717A1

公开(公告)日：2014-09-11

申请号：US14118009

申请日：2012-05-18

申请人： Joaquín Pastor Fernández ,  Rosa Maria Álvarez Escobar ,  Rosario Concepción Riesco Fagundo ,  Ana Belén García García ,  Antonio Rodríguez Hergueta ,  Jose Ignacio Martin Hernando ,  Carmen Blanco Aparicio ,  David Álvaro Cebrián Muñoz

发明人： Joaquín Pastor Fernández ,  Rosa Maria Álvarez Escobar ,  Rosario Concepción Riesco Fagundo ,  Ana Belén García García ,  Antonio Rodríguez Hergueta ,  Jose Ignacio Martin Hernando ,  Carmen Blanco Aparicio ,  David Álvaro Cebrián Muñoz

IPC分类号： C07D515/22 ,  A61K31/4745 ,  A61K45/06 ,  A61K31/5383 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/4375 ,  C07D513/22 ,  C07D513/16

CPC分类号： A61K31/5383 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/4745 ,  A61K31/5025 ,  A61K31/519 ,  A61K45/06 ,  C07D513/16 ,  C07D513/22 ,  C07D515/22 ,  A61K2300/00

摘要： There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.

摘要翻译： 提供了式I化合物，其中R 1，R 2a，R 2b，R 2c，X，Y，Z，R 3和环A / B具有本说明书中给出的含义及其药学上可接受的酯，酰胺，溶剂合物或盐， 化合物可用于治疗其中期望和/或需要蛋白质或脂质激酶（例如PI3-K，特别是I型PI3K，PIM家族激酶和/或mTOR）的抑制，特别是治疗癌症的疾病 。 本发明还涉及含有这些化合物的组合。

公开(公告)号：US20130210803A1

公开(公告)日：2013-08-15

申请号：US13579900

申请日：2011-02-18

申请人： Sarvajit Chakravarty ,  Barry Patrick Hart ,  Rajendra Parasmal Jain

发明人： Sarvajit Chakravarty ,  Barry Patrick Hart ,  Rajendra Parasmal Jain

IPC分类号： C07D471/14 ,  C07D513/00 ,  C07D471/18 ,  C07D498/14

CPC分类号： C07D471/14 ,  C07D471/16 ,  C07D471/18 ,  C07D471/22 ,  C07D498/14 ,  C07D498/16 ,  C07D513/00 ,  C07D513/16

摘要： This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

摘要翻译： 本公开涉及稠合的四环吡啶并[4,3-b]吲哚和吡啶并[3,4-b]吲哚。 还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

公开(公告)号：US20060128741A1

公开(公告)日：2006-06-15

申请号：US11271598

申请日：2005-11-10

申请人： Jagabandhu Das ,  James Kempson ,  William Pitts ,  Steven Spergel

发明人： Jagabandhu Das ,  James Kempson ,  William Pitts ,  Steven Spergel

IPC分类号： A61K31/4745 ,  C07D498/14

CPC分类号： C07D513/14 ,  C07D513/16

摘要： The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

摘要翻译： 本发明提供具有式（I）的噻唑并吡啶类三环化合物，其中R 1，R 2，R 5和R 5， SUP> 6 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

公开(公告)号：US06875762B2

公开(公告)日：2005-04-05

申请号：US10744999

申请日：2003-12-23

申请人： Jackson B. Hester ,  Bruce N. Rogers ,  Eric Jon Jacobsen ,  Michael D. Ennis ,  Brad A. Acker ,  Susan L. Vander Velde ,  Kristine E. Frank

发明人： Jackson B. Hester ,  Bruce N. Rogers ,  Eric Jon Jacobsen ,  Michael D. Ennis ,  Brad A. Acker ,  Susan L. Vander Velde ,  Kristine E. Frank

IPC分类号： A61K31/55 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P37/04 ,  C07D471/16 ,  C07D487/14 ,  C07D487/16 ,  C07D498/16 ,  C07D513/16

CPC分类号： C07D471/16 ,  C07D487/16 ,  C07D498/16 ,  C07D513/16

摘要： The present invention provides compounds of formula I: wherein R1, R2, X and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I).

摘要翻译： 本发明提供式I化合物：其中R1，R2，X和Y具有说明书中定义的任何值，以及包含该化合物的药物组合物。 本发明还提供治疗方法以及可用于制备式（I）化合物的方法和中间体。

公开(公告)号：US06849619B2

公开(公告)日：2005-02-01

申请号：US10784064

申请日：2004-02-20

申请人： Albert J. Robichaud ,  John M. Fevig ,  Ian S. Mitchell ,  Taekyu Lee ,  Wenting Chen ,  Joseph Cacciola

发明人： Albert J. Robichaud ,  John M. Fevig ,  Ian S. Mitchell ,  Taekyu Lee ,  Wenting Chen ,  Joseph Cacciola

IPC分类号： C07D471/16 ,  C07D498/16 ,  C07D513/16 ,  A61K31/33 ,  A61K31/55 ,  C07D223/14 ,  C07D245/00 ,  C07D267/02

CPC分类号： C07D471/16 ,  C07D498/16 ,  C07D513/16

摘要： The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

摘要翻译： 本发明涉及由结构式（I）表示的某些新化合物或其药学上可接受的盐形式，其中R 1，R 5，R 6，R 7，R 8，R <9>，X，b，k和n，这里描述虚线。 本发明还涉及包含这些新化合物作为活性成分的药物制剂，以及新型化合物及其制剂在治疗某些疾病中的用途。 本发明的化合物是血清素激动剂和拮抗剂，可用于控制或预防中枢神经系统疾病，包括肥胖症，焦虑症，抑郁症，精神病，精神分裂症，睡眠障碍，性障碍，偏头痛，与头痛相关的病症，社交恐怖症 ，以及胃肠道疾病如胃肠道运动功能障碍。