公开(公告)号：US08109895B2

公开(公告)日：2012-02-07

申请号：US11897701

申请日：2007-08-31

申请人： Michael S. Williams ,  Daniel W. Fifer ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  William L. Athas ,  Richard S. Stack

发明人： Michael S. Williams ,  Daniel W. Fifer ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  William L. Athas ,  Richard S. Stack

IPC分类号： A61M5/00

CPC分类号： A61F5/0036 ,  A61F2/04 ,  A61F2/07 ,  A61F2/95 ,  A61F5/0076 ,  A61F5/0089 ,  A61F2002/044 ,  A61F2002/045

摘要： An intestinal implant includes a proximal anchor self-expandable from a radially compressed position to a radially expandable position for engagement with a wall of the intestinal lumen and a flexible sleeve coupled to the anchor. The sleeve is implanted with the anchor downstream from the pylorus and the sleeve extending further downstream through the intestinal lumen.

摘要翻译： 肠植入物包括从径向压缩位置到径向可扩张位置的可自膨胀的近端锚固件，用于与肠腔的壁接合，以及联接到锚的柔性套管。 套管被植入幽门下游的锚固件，并且套筒在下游延伸穿过肠腔。

公开(公告)号：US20110270410A1

公开(公告)日：2011-11-03

申请号：US13182965

申请日：2011-07-14

申请人： Richard S. Stack ,  Richard A. Glenn ,  William L. Athas ,  Michael S. Williams

发明人： Richard S. Stack ,  Richard A. Glenn ,  William L. Athas ,  Michael S. Williams

IPC分类号： A61F2/04

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F2/07 ,  A61F2/24 ,  A61F5/0036 ,  A61F5/0079 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2002/067 ,  A61F2002/8483 ,  A61F2230/0067 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A device for inducing weight loss in a patient includes a tubular prosthesis positionable at the gastro-esophageal junction region, preferably below the z-line. In a method for inducing weight loss, the prosthesis is placed such that an opening at its proximal end receives masticated food from the esophagus, and such that the masticated food passes through the pouch and into the stomach via an opening in its distal end.

摘要翻译： 用于在患者中引起体重减轻的装置包括可在胃食管连接区域定位的管状假体，优选在z线下方。 在用于引起体重减轻的方法中，假体被放置成使得其近端处的开口从食管接收咀嚼的食物，并且使得咀嚼食物通过其远端中的开口通过袋并进入胃。

公开(公告)号：US20110118545A1

公开(公告)日：2011-05-19

申请号：US13007974

申请日：2011-01-17

申请人： Michael S. Williams ,  Richard S. Stack ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  Daniel W. Fifer ,  William L. Athas ,  Aurora Pryor

发明人： Michael S. Williams ,  Richard S. Stack ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  Daniel W. Fifer ,  William L. Athas ,  Aurora Pryor

IPC分类号： A61B1/00

CPC分类号： A61B17/3476 ,  A61B1/00052 ,  A61B1/00128 ,  A61B1/00135 ,  A61B1/018 ,  A61B17/0218 ,  A61B17/29 ,  A61B17/3403 ,  A61B17/3421 ,  A61B90/50 ,  A61B2017/00225 ,  A61B2017/00278 ,  A61B2017/003 ,  A61B2017/2905 ,  A61B2017/2906 ,  A61B2017/3407 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2017/3486 ,  A61B2090/372 ,  A61M25/0147 ,  A61M2210/101

摘要： A system for performing multi-tool minimally invasive medical procedures through a single instrument port into a body cavity includes a rigid tube carried by a mount. Cannulas having instrument channels and steerable distal ends extend distally from the rigid tube. During a procedure using the system, the mount is supported by an operating room fixture, and instruments are advanced through the steerable instrument channels. Manipulation of the instrument handles engages actuators positioned on the mount, which steer the distal ends of the cannulas through the action of pull cables. The distal ends of the instruments may thus be steered within the body by the distal ends of the steerable cannulas.

摘要翻译： 用于通过单个仪器端口执行多工具微创医疗程序进入体腔的系统包括由安装座承载的刚性管。 具有仪器通道和可操纵远端的插管从刚性管向远端延伸。 在使用该系统的过程中，安装座由手术室夹具支撑，仪器通过导向仪器通道前进。 操纵仪器把手接合位于安装座上的致动器，其通过拉电缆的作用转向插管的远端。 因此，仪器的远端可以由可操纵的插管的远端转向体内。

公开(公告)号：US07152607B2

公开(公告)日：2006-12-26

申请号：US10794007

申请日：2004-03-04

申请人： Richard S. Stack ,  Richard A. Glenn ,  William L. Athas ,  Michael S. Williams

发明人： Richard S. Stack ,  Richard A. Glenn ,  William L. Athas ,  Michael S. Williams

IPC分类号： A61B19/00 ,  A61F2/04 ,  A61F2/00

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F2/07 ,  A61F2/24 ,  A61F5/0089 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2002/067 ,  A61F2002/8483 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A device for inducing weight loss in a patient includes a tubular prosthesis positionable at the gastro-esophageal junction region, preferably below the z-line. In a method for inducing weight loss, the prosthesis is placed such that an opening at its proximal end receives masticated food from the esophagus, and such that the masticated food passes through the pouch and into the stomach via an opening in its distal end.

公开(公告)号：US20090157076A1

公开(公告)日：2009-06-18

申请号：US12209586

申请日：2008-09-12

申请人： William L. Athas ,  Thomas B. Miller ,  Aurora Pryor ,  Geoffrey A. Orth ,  Michael S. Williams ,  Jeffrey A. Smith ,  Richard A. Glenn ,  Daniel W. Fifer

发明人： William L. Athas ,  Thomas B. Miller ,  Aurora Pryor ,  Geoffrey A. Orth ,  Michael S. Williams ,  Jeffrey A. Smith ,  Richard A. Glenn ,  Daniel W. Fifer

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61B18/18

CPC分类号： A61B17/3421 ,  A61B18/1477 ,  A61B18/1482 ,  A61B2017/003 ,  A61B2017/00349 ,  A61B2017/320044 ,  A61B2017/320048 ,  A61B2017/320056 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2018/00214 ,  A61B2018/1407 ,  A61B2018/144

摘要： A system for minimally invasive medical procedures includes an elongate tubular access cannula comprising an elongate tubular member having a rigid proximal portion and an articulating portion. The tubular member has a first branch and a tubular bifurcation extending from the first branch, allowing simultaneous use of multiple instruments. A dissector suitable for use with the access cannula, or other access devices, for implantation of gastric bands or for other procedures includes a pre-curved distal portion having a dissection element such as a monopolar RF conductor and/or a dissection balloon, as well as a snare. In one method, the dissector is advanced around the posterior side of the stomach to form a tunnel in the connective tissue, and the snare is then extended from the dissector to engage a portion of the band and withdraw it through the tunnel.

摘要翻译： 用于微创医疗程序的系统包括细长管状进入套管，其包括具有刚性近端部分和铰接部分的细长管状构件。 管状构件具有从第一分支延伸的第一分支和管状分叉，允许同时使用多个仪器。 适合与入口插管或其他进入装置一起用于植入胃束带或用于其他程序的解剖器包括具有解剖元件的预弯曲远侧部分，例如单极RF导体和/或解剖气囊，以及 作为一个圈套 在一种方法中，解剖器在胃的后部周围前进，以在结缔组织中形成隧道，然后将圈套从解剖器延伸以接合带的一部分并将其从隧道中取出。

公开(公告)号：US20100023088A1

公开(公告)日：2010-01-28

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/36 ,  A61N7/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US20110166482A1

公开(公告)日：2011-07-07

申请号：US13042350

申请日：2011-03-07

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/36 ,  A61N7/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US07925352B2

公开(公告)日：2011-04-12

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US08428730B2

公开(公告)日：2013-04-23

申请号：US13286217

申请日：2011-11-01

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

公开(公告)号：US08369954B2

公开(公告)日：2013-02-05

申请号：US13042350

申请日：2011-03-07

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。