Methods and apparatus for performing retention-time matching
    41.
    发明授权
    Methods and apparatus for performing retention-time matching 有权
    用于执行保留时间匹配的方法和装置

    公开(公告)号:US08165820B2

    公开(公告)日:2012-04-24

    申请号:US11916322

    申请日:2006-06-05

    IPC分类号: G06F19/00

    摘要: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.

    摘要翻译: 用于将前体离子与一种或多种相关产物离子相匹配的方法包括提供从样品注射获得的输入数据集,每个数据集包括前体离子和一种或多种产物离子,根据单一方法对输入数据集进行归一化 前体离子的保留时间,确定哪个产物离子相对于单个保留时间在预定的保留时间窗内,并且如果产物离子在指定数量的输入数据集的预定保留时间窗内,则确定 产物离子与具有单一保留时间的前体相关。 用于分析样品的装置包括色谱模块,与色谱模块连通的质谱模块,以及与色谱模块和质谱模块连通的控制单元。