公开(公告)号：US20240355608A1

公开(公告)日：2024-10-24

申请号：US18641183

申请日：2024-04-19

申请人： Thermo Fisher Scientific (Bremen) GmbH

发明人： Jan-Peter HAUSCHILD ,  Tobias WOERNER ,  Kyle FORT ,  Alexander MAKAROV ,  Konstantin AIZIKOV

IPC分类号： H01J49/24 ,  G01N30/72 ,  H01J49/00 ,  H01J49/26

CPC分类号： H01J49/24 ,  G01N30/72 ,  H01J49/0009 ,  H01J49/26

摘要： Mass spectrometry systems for performing mass analysis on ion samples include a vacuum region comprising a mass analyser configured to provide a detection signal for the ion sample. A turbomolecular pump is configured to maintain the vacuum region at a vacuum pressure and a controller is configured to control the pressure within the mass analyser to control the rate of decay over time of the detection signal for the ion sample by: controlling a pumping speed of the turbomolecular pump. The turbomolecular pump can be configured to maintain the vacuum region at a first pressure when the mass analyser is being operated in a mass analysis mode of operation and a second pressure when the mass analyser is being operated in a collision cross section analysis mode of operation, wherein the second pressure is greater than the first pressure.

公开(公告)号：US12111285B2

公开(公告)日：2024-10-08

申请号：US17767946

申请日：2019-11-11

申请人： SHIMADZU CORPORATION

发明人： Hidenori Takahashi ,  Sadanori Sekiya ,  Shosei Yamauchi

IPC分类号： G01N27/62 ,  H01J49/26

CPC分类号： G01N27/62 ,  H01J49/26

摘要： First product ion spectrum data is acquired by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; second product ion spectrum data is acquired by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and a set of product ions having a predetermined mass difference is extracted in the first product ion spectrum data and the second product ion spectrum data.

公开(公告)号：US12106954B2

公开(公告)日：2024-10-01

申请号：US17277999

申请日：2019-10-17

申请人： SHIMADZU CORPORATION

发明人： Yiming Lin ,  Wenjian Sun

IPC分类号： H01J49/16 ,  H01J49/04 ,  H01J49/26

CPC分类号： H01J49/16 ,  H01J49/04 ,  H01J49/26

摘要： The present invention provides dielectric barrier discharge ionization, including a dielectric barrier discharge tube and an electrode pair consisting of a first electrode and a second electrode. At least a portion of the dielectric barrier discharge tube is provided between the first electrode and the second electrode. The electrode pair can ionize the sample after the power is turned on. The dielectric barrier discharge tube is in communication with a vacuum portion. The pressure range in the dielectric barrier discharge tube is 0.01 to 100 Pa. The dielectric barrier discharge ionization provided by the invention remedies the defects of existing low-pressure ion sources in the pressure range, and provides the low-pressure ion source with high ionization ability, high versatility and simple devices.

公开(公告)号：US12074017B2

公开(公告)日：2024-08-27

申请号：US17166757

申请日：2021-02-03

申请人： Elemental Scientific, Inc.

发明人： Charles D. Quarles, Jr.

IPC分类号： H01J49/04 ,  B01L3/00 ,  G01N30/72 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

CPC分类号： H01J49/0413 ,  B01L3/502 ,  B01L3/567 ,  G01N30/72 ,  H01J49/105 ,  H01J49/165 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/049 ,  H01J49/26

摘要： Systems and methods for controlled, inline introduction of chemical agents to an inline fluid sample are described. A method embodiment includes, but is not limited to, receiving a fluid sample with a valve; receiving a chemical agent with the valve; introducing the fluid sample and the chemical agent inline via a mixing port of the valve to produce a mixed sample; transferring the mixed sample to a second valve; directing the mixed sample to a sample holding loop fluidically coupled with the second valve; holding the mixed sample within the sample holding loop for a holding period of time to permit a reaction between the fluid sample and the chemical agent; and directing the mixed sample from the sample holding loop to an analytic instrument following expiration of the holding period of time.

公开(公告)号：US20240266157A1

公开(公告)日：2024-08-08

申请号：US18615240

申请日：2024-03-25

申请人： ADAPTAS SOLUTIONS PTY LTD

发明人： Russell Jurek ,  David Dellagiacoma ,  Kevin Hunter

IPC分类号： H01J43/28 ,  H01J49/02 ,  H01J49/26

CPC分类号： H01J43/28 ,  H01J49/025 ,  H01J49/26

摘要： A detector includes: one or more electron emissive surfaces; first and second housing elements defining a space therebetween; and a deformable member or a deformable mass some or all of which occupies the space. The first and second housing elements and the deformable member or the deformable mass define on one side an environment internal the detector and on another side an environment external the detector. The deformable member or the deformable mass has a central region which when contacted by the first and/or second housing elements is deformed so as to inhibit or prevent passage of a gas through the space.

公开(公告)号：US20240242955A1

公开(公告)日：2024-07-18

申请号：US18436697

申请日：2024-02-08

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： David E. CLEMMER ,  Martin F. JARROLD ,  Tarick J. EL-BABA ,  Corinne A. LUTOMSKI

IPC分类号： H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  H01J49/26

CPC分类号： H01J49/165 ,  H01J49/0031 ,  H01J49/0468 ,  H01J49/26

摘要： A method for analyzing charged particles may include generating, in or into an ion source region, charged particles from a sample of particles, causing the charged particles to enter a mass spectrometer from the ion source region at each of a plurality of differing physical and/or chemical conditions in a range of physical and/or chemical conditions in which the sample particles undergo structural changes, controlling the mass spectrometer to measure at least the charge magnitudes of the generated charged particles at each of the plurality of differing physical and/or chemical conditions, determining, with a processor, an average charge magnitude of the generated charged particles at each of the plurality of differing physical and/or chemical conditions based on the measured charge magnitudes, and determining, with the processor, an average charge magnitude profile over the range of physical and/or chemical conditions based on the determined average charge magnitudes.

公开(公告)号：US20240003847A1

公开(公告)日：2024-01-04

申请号：US18369045

申请日：2023-09-15

申请人： Battelle Memorial Institute

发明人： Venkata B.S. Garimella ,  Ahmed M. Hamid ,  Yehia M. Ibrahim ,  Richard D. Smith

IPC分类号： G01N27/624 ,  H01J49/06 ,  H01J49/00 ,  H01J49/26

CPC分类号： G01N27/624 ,  H01J49/062 ,  H01J49/0027 ,  H01J49/26

摘要： Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.

公开(公告)号：US11841307B2

公开(公告)日：2023-12-12

申请号：US16348790

申请日：2017-11-09

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Igor Paprotny

IPC分类号： G01N15/06 ,  G01N1/40 ,  G01N29/02 ,  G01N29/036 ,  G01N21/17 ,  G01N29/44 ,  H01J49/26 ,  G01N15/02 ,  G01N15/00 ,  G01H11/08 ,  G01N5/02

CPC分类号： G01N15/0606 ,  G01N1/4005 ,  G01N15/0255 ,  G01N21/17 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4436 ,  H01J49/26 ,  G01H11/08 ,  G01N5/02 ,  G01N2015/0046 ,  G01N2291/0215 ,  G01N2291/02408

摘要： Microfabricated PM sensors measure concentrations of particulate matter (PM) in air. Some sensors improve the accuracy of measurements by accounting for the effect of ambient conditions (e.g., temperature or humidity) on mass-sensitive elements employed to determine a mass of the PM in a stream of air. Some sensors improve the accuracy of measurements by controlling humidity in the stream of air measured by mass-sensitive elements. Some sensors employ a plurality of mass-sensitive elements to extend the useful life of the PM sensor. Some sensors employ one or more mass-sensitive elements and heating elements to cause deposition and allow measurement of different sizes of PM. Some sensors can measure mass concentration of coarse PM in addition to fine PM in a stream of air. Some sensors control the flow rate of a stream of air measured by mass-sensitive elements. Some sensors include features to mitigate electromagnetic interference or electromagnetic signal loss.

公开(公告)号：US20230363076A1

公开(公告)日：2023-11-09

申请号：US18026245

申请日：2021-04-26

申请人： SHIMADZU CORPORATION

发明人： Masaji FURUTA

IPC分类号： H05H1/30 ,  G01N27/623

CPC分类号： H05H1/30 ,  G01N27/623 ,  H01J49/26

摘要： A radical generation device includes: a cylindrical tube; an antenna; an outer conductor part; and a connection part which has a double cylindrical tube structure including an inner cylindrical body and an outer cylindrical body, end portions of the inner cylindrical body and the outer cylindrical body on the same side are divided in a circumferential direction notches extending in an axial direction to form divided pieces, and tapered portions swelling outward toward a tip end are formed on an outer side of the divided pieces or tapered portions swelling inward toward a tip end are formed on an inner side of the divided pieces.

公开(公告)号：US11721533B1

公开(公告)日：2023-08-08

申请号：US17033535

申请日：2020-09-25

申请人： InspectIR Systems, LLC ,  University of North Texas

发明人： Guido Fridolin Verbeck, IV ,  John Redmond ,  Tim C. Wing ,  Luke Keiser

IPC分类号： H01J49/00 ,  A61B5/097 ,  A61B5/08 ,  A61B5/00 ,  H01J49/26 ,  G01N21/3504 ,  G01N33/497 ,  G01N21/64 ,  G01N21/3581 ,  H01J49/24

CPC分类号： H01J49/0031 ,  A61B5/082 ,  A61B5/097 ,  A61B5/4845 ,  G01N21/3504 ,  G01N21/3581 ,  G01N21/64 ,  G01N33/497 ,  H01J49/0013 ,  H01J49/24 ,  H01J49/26 ,  G01N2201/06113

摘要： An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may ramp heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector, lighter and/or less bound VOCs first, heavier and/or more strongly bound VOCs later. An analysis device (e.g., a mass spectrometer or a Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified target VOC(s). The output may include information that quantitates a concentration of the target VOC(s) with respect to a source of the breath sample.