公开(公告)号：US06445954B1

公开(公告)日：2002-09-03

申请号：US09542964

申请日：2000-04-04

申请人： Arthur L. Olive ,  Ronald W. Heil, Jr.

发明人： Arthur L. Olive ,  Ronald W. Heil, Jr.

IPC分类号： A61N102

CPC分类号： A61N1/056 ,  A61N2001/0578

摘要： A cardiac lead introducing apparatus, the cardiac lead introducing apparatus having a sleeve with a peripheral surface, a first end and a second end, where the sleeve includes an opening extending from the first end to the second end and adapted to hold at least a portion of a cardiac lead. The cardiac lead introducing apparatus further includes a first slit extending from the peripheral surface to the opening and from the first end to the second end which permits the sleeve to separate so the cardiac lead can pass through the cardiac lead introducing apparatus without any longitudinal motion of the device with respect to the cardiac lead. In one embodiment, the diameter of the opening is smaller than the outer diameter of the cardiac lead which permits the cardiac lead to be held static within the introducing apparatus as the lead connector of the cardiac lead is inserted into the socket of an implantable pulse generator connector block.

摘要翻译： 一种心脏引导引入装置，所述心脏引导引入装置具有带有外周表面的套筒，第一端和第二端，其中所述套筒包括从所述第一端延伸到所述第二端的开口，并且适于保持至少一部分 的心脏铅。 所述心脏引导引入装置还包括从所述外周表面延伸到所述开口并从所述第一端延伸至所述第二端的第一狭缝，所述第一狭缝允许所述套筒分离，使得所述心脏引线可以穿过所述心脏引线引入装置，而不进行任何纵向运动 该装置相对于心脏引线。 在一个实施例中，开口的直径小于心脏引线的外径，其允许心脏引线在引入装置内保持静止，因为心脏引线的引线连接器插入到可植入脉冲发生器的插座中 连接器块。

公开(公告)号：US06361522B1

公开(公告)日：2002-03-26

申请号：US09422433

申请日：1999-10-21

申请人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

发明人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

IPC分类号： A61M3100

CPC分类号： A61N1/30 ,  A61N1/3621 ,  Y10S128/12 ,  Y10S128/13

摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

公开(公告)号：US5397342A

公开(公告)日：1995-03-14

申请号：US71859

申请日：1993-06-07

申请人： Ronald W. Heil, Jr. ,  Bruce H. Kenknight ,  Robert W. Wickham, Jr., deceased ,  by Duane R. Quiggle, legal administrator

发明人： Ronald W. Heil, Jr. ,  Bruce H. Kenknight ,  Robert W. Wickham, Jr., deceased ,  by Duane R. Quiggle, legal administrator

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： A cardioversion/defibrillation device includes a lead catheter housing, two electrically independent conductors, and a pair of resilient helically coiled electrodes, one electrode coupled to each of the conductors. The distal ends of the electrodes are contained within an insulative, resilient coupling sleeve, such that the electrodes and sleeve form a loop when in the relaxed state, with the electrodes electrically isolated from one another. To facilitate body insertion and delivery to the electrode placement site, the electrodes and coupling sleeve are loaded into a delivery cannula, which elastically deforms the electrodes and sleeve into an elongate, narrow delivery configuration. Upon release from the delivery device, these components resiliently return to the loop configuration. If desired, an inextensible filament secured to the coupling sleeve is pulled proximally after deployment to selectively reconfigure the electrodes into two loops. Another modification involves several linear electrode branch segments, coupled to each electrode and projected inwardly of the loop or loops formed by the electrodes.

摘要翻译： 心脏复律/除颤装置包括引导导管壳体，两个电独立导体和一对弹性螺旋线圈电极，一个电极连接到每个导体。 电极的远端包含在绝缘的弹性联接套筒内，使得当处于松弛状态时，电极和套管形成环，其中电极彼此电隔离。 为了便于身体插入和输送到电极放置位置，电极和联接套筒被装载到输送套管中，该插管使电极和套管弹性变形成细长的狭窄输送构型。 当从传送装置释放时，这些部件弹性地返回到环路配置。 如果需要，固定到联接套筒的不可伸长的细丝在展开之后被向近侧拉动以选择性地将电极重新配置成两个环。 另一个修改涉及几个线性电极分支段，耦合到每个电极并且由电极形成的环或环的内部突出。

公开(公告)号：US5191901A

公开(公告)日：1993-03-09

申请号：US751533

申请日：1991-08-29

申请人： Roger W. Dahl ,  Ronald W. Heil, Jr.

发明人： Roger W. Dahl ,  Ronald W. Heil, Jr.

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： A defibrillation electrode for implantation on or about the heart and for connection to a defibrillation system. The electrode comprises a plurality of electrically conductive elements spaced apart and electrically connected together, thus, increasing the number of discharging edges on the electrode. In a first embodiment, the electrode comprises a plurality of concentric conductive rings electrically connected together. In a second embodiment, the electrode comprises a plurality of conductive planar elements electrically connected together in a generally puzzle-like configuration. In a third embodiment, the electrode comprises electrically conductive wires wrapped around the length of a cardiac catheter. In a fourth embodiment, electrically conductive wires are concentrically spiralled into a spiral patch configuration. In a fifth specific embodiment, a plurality of electrically isolated active sites are provided on the distal portion of an endocardial catheter. In all of the above embodiments, the electrical discharge of energy from the electrode to the heart surface favors the conductive edges of the electrically conductive and connected components of the electrodes. Therefore, by increasing the number of conductive edges, a more uniform distribution of energy is delivered to the heart. Furthermore, each of the electrode configurations may be constructed without an insulative backing to further increase the efficiency of discharge.

摘要翻译： 用于植入在心脏上或其周围并用于与除颤系统连接的除颤电极。 电极包括间隔开并电连接在一起的多个导电元件，从而增加电极上的放电边缘的数量。 在第一实施例中，电极包括电连接在一起的多个同心导电环。 在第二实施例中，电极包括多个导电平面元件，其以通常的益智构型电连接在一起。 在第三实施例中，电极包括围绕心脏导管的长度缠绕的导电线。 在第四实施例中，导电线同心地螺旋成螺旋形贴片构型。 在第五具体实施方案中，在心内膜导管的远侧部分上设置多个电隔离的活性部位。 在所有上述实施例中，从电极到心脏表面的能量放电有利于电极的导电和连接部件的导电边缘。 因此，通过增加导电边缘的数量，将更均匀的能量分布传递到心脏。 此外，每个电极配置可以构造成没有绝缘背衬，以进一步提高放电效率。

公开(公告)号：US5085218A

公开(公告)日：1992-02-04

申请号：US575879

申请日：1990-08-31

申请人： Ronald W. Heil, Jr. ,  Robert W. Wickham, Jr. ,  Edward D. Kubitschek

发明人： Ronald W. Heil, Jr. ,  Robert W. Wickham, Jr. ,  Edward D. Kubitschek

IPC分类号： A61N1/05 ,  A61N1/375

CPC分类号： A61N1/059

摘要： A bipolar lead for use in sensing cardiac depolarization signals and for applying electrical stimulation to cardiac tissue comprises a pair of elongated conductors contained within a lead body, the lead body terminating at its distal end in an enlarged head fabricated from an insulating plastic material. The head has a generally planar surface and projecting perpendicularly from that surface is a corkscrew electrode which is adapted to be screwed into myocardial tissue. Also supported on the planar surface of the head so as to surround the corkscrew electrode is a toroidal electrode formed from helically wound conductive wire. One of the conductors passing through the lead body connects at its distal end to the corkscrew electrode which the other conductor attached to the toroidal electrode. The toroidal configuration of the helically wound wire provides substantially increased surface area when compared to a flat disk electrode and, moreover, offers the ability of tissue to grow into the interior regions of the toroidal electrode for improved anchoring, higher amplitude of the sense depolarization signals and a higher slew rate for the signal. Another feature of the invention involves filling the interior of the hollow torus structure with a wool-like material formed from platinum or other inert conductive material for even further increasing the amount of electrode surface in contact with tissue.

摘要翻译： 用于感测心脏去极化信号和用于对心脏组织施加电刺激的双极引线包括一对包含在引线体内的细长导体，该引线体在其远端终止于由绝缘塑料材料制成的扩大头部中。 头部具有大致平坦的表面并且从该表面垂直突出的是适于被拧入心肌组织的开塞钻电极。 头部的平面表面也被支撑在围绕螺丝起子电极的是螺旋缠绕导电线形成的环形电极。 穿过引线体的导体之一在其远端连接到螺旋电极，另一个导体连接到环形电极。 与平盘电极相比，螺旋缠绕线的环形构造提供了显着增加的表面积，此外，提供组织生长到环形电极的内部区域以改善锚固的能力，更高的感测去极化信号的幅度 和信号的较高的转换速率。 本发明的另一特征包括用由铂或其它惰性导电材料形成的羊毛状材料填充中空圆环结构的内部，以进一步增加与组织接触的电极表面的量。

公开(公告)号：US5041107A

公开(公告)日：1991-08-20

申请号：US418249

申请日：1989-10-06

申请人： Ronald W. Heil, Jr.

发明人： Ronald W. Heil, Jr.

IPC分类号： A61N1/30

CPC分类号： A61N1/306

摘要： An implantable apparatus for continuous or periodic introduction of a drug to a desired release point in the body comprises an implantable power source and an elongated flexible plastic tubular catheter having a lumen filled with the drug to be delivered and containing therein a first device electrode. The distal end of the catheter is closed and located near the distal end is a port which extends through the wall of the catheter to communicate with the lumen. Just proximal of the port is a surface electrode mounted on the exterior wall of the catheter body. Extending through the catheter and joined to the drive electrode and the surface electrode are conductors which couple those electrodes to the implanted power source. Energization of the electrodes with a predetermined direct current potential causes a flow of the ionized drug molecules out through the port and into the area surrounding the surface electrode.

摘要翻译： 用于将药物连续或周期性地引入到身体中所需释放点的可植入装置包括可植入动力源和细长的柔性塑料管状导管，其具有填充有待输送药物的腔，并且在其中容纳第一装置电极。 导管的远端是封闭的并且位于远端附近是一个延伸穿过导管的壁与腔连通的端口。 靠近端口的是安装在导管主体的外壁上的表面电极。 通过导管延伸并连接到驱动电极和表面电极是将这些电极耦合到植入电源的导体。 具有预定直流电势的电极的通电导致离子化的药物分子流过端口并进入表面电极周围的区域。

公开(公告)号：US4819662A

公开(公告)日：1989-04-11

申请号：US112518

申请日：1987-10-26

申请人： Ronald W. Heil, Jr. ,  Robert C. Owens ,  Brian D. Pederson

发明人： Ronald W. Heil, Jr. ,  Robert C. Owens ,  Brian D. Pederson

IPC分类号： A61N1/05 ,  A61N1/00

CPC分类号： A61N1/0568

摘要： An implantable cardiac pacing lead includes a porous, platinum electrode, a flexible electrically conductive coil, and a crimp tube coupling the electrode to the distal end of the coil. A recess in the crimp tube, open to the electrode at the crimp tube distal end, houses a matrix impregnated with a therapeutic drug. The electrode is highly porous and loaded with a therapeutic drug in liquid or solid form. Immediately upon implant of the electrode at a selected myocardial location, the electrode begins dispensing the therapeutic drug. Meanwhile, the matrix begins to elute its drug at a rate more suited to chronic treatment. If desired, the recess can extend through the crimp tube to permit proximal end loading of the drug carrying matrix. A silicone plug, or an additional and proximal crimp tube section, is inserted into the recess after loading of the matrix to provide the required fluid seal. Finally, a variety of different matrices can be housed in the recess, to provide elution of different drugs and at differing rates.

摘要翻译： 可植入心脏起搏引线包括多孔铂电极，柔性导电线圈和将电极耦合到线圈的远端的压接管。 在压接管远端的电极开口的压接管中的凹部容纳浸有治疗药物的基质。 电极是高度多孔的，并以液体或固体形式装载治疗药物。 在选定的心肌位置植入电极后，电极开始分配治疗药物。 同时，矩阵开始以更适合慢性治疗的速度洗脱药物。 如果需要，凹槽可以延伸穿过压接管以允许携带药物的基质的近端负载。 在加载基质以提供所需的流体密封之后，硅胶塞或附加的和近端的卷边管部分被插入到凹槽中。 最后，可以将许多不同的基质容纳在凹槽中，以提供不同药物和不同速率的洗脱。

公开(公告)号：US09031792B2

公开(公告)日：2015-05-12

申请号：US11277552

申请日：2006-03-27

申请人： Darrell O. Wagner ,  Haris J. Sih ,  Jihong Qu ,  Jeffrey Ross ,  Steven D. Girouard ,  Ronald W. Heil, Jr.

发明人： Darrell O. Wagner ,  Haris J. Sih ,  Jihong Qu ,  Jeffrey Ross ,  Steven D. Girouard ,  Ronald W. Heil, Jr.

IPC分类号： G01N33/48 ,  A61K48/00 ,  A61N1/05

CPC分类号： A61K48/0008 ,  A61K48/0083 ,  A61N1/05

摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

摘要翻译： 提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

公开(公告)号：US08639322B2

公开(公告)日：2014-01-28

申请号：US13484060

申请日：2012-05-30

申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US08195289B2

公开(公告)日：2012-06-05

申请号：US12627562

申请日：2009-11-30

申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。