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41.发明申请公开(公告)号：US20060004085A1
公开(公告)日：2006-01-05
申请号：US11155617
申请日：2005-06-20
IPC分类号： A61K31/4035
CPC分类号： A61K31/4035
摘要： Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.
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公开(公告)号：US20050154399A1
公开(公告)日：2005-07-14
申请号：US11021947
申请日：2004-12-23
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
CPC分类号： A61F2/167 , A61F9/0017 , A61F9/007
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译： 用于输送眼部植入物或微量植入物的装置和方法。 该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。 提供小尺寸插管用于自密封输送方法。
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公开(公告)号：US06899717B2
公开(公告)日：2005-05-31
申请号：US10246884
申请日：2002-09-18
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61B17/3468
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
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公开(公告)号：US20050101967A1
公开(公告)日：2005-05-12
申请号：US10666872
申请日：2003-09-18
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译： 用于输送眼部植入物或微量植入物的装置和方法。 该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。 提供小尺寸插管用于自密封输送方法。
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公开(公告)号：US5847086A
公开(公告)日：1998-12-08
申请号：US487445
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K38/00 , A61K38/36 , A61P7/02 , A61P9/00 , A61P43/00 , C07K1/22 , C07K14/745 , C07K14/755 , A61K35/14
CPC分类号： C07K14/755 , A61K38/00
摘要： Processes for preparing aqueous solutions of cysteine-altered von Willebrand Factor fragment which are substantially free of aggregate and capable of therapeutic use for treating thrombosis are provided. The claimed process comprises providing an aqueous solution of vWF fragment and denaturant and containing undesired contaminants, said solution having an acidic pH; separating said contaminants from said solution by contacting said solution with an affinity chromatography medium to which said vWF fragments adhere; eluting said vWF fragment from said affinity chromatography medium in the presence of the denaturant; and separating the eluted fragment from said denaturant while maintaining the aqueous solution of the fragment at a pH of about 2.5 to less than about 5.5 to increase monomerization of, and decrease aggregation of, said fragment, thereby forming an aqueous solution of vWF fragment which is substantially free of aggregate.
摘要翻译： 提供了制备基本上不含聚集体并能治疗用于治疗血栓形成的半胱氨酸改变的血管性血友病因子片段的水溶液的方法。 所要求的方法包括提供vWF片段和变性剂的水溶液并含有不期望的污染物，所述溶液具有酸性pH; 通过使所述溶液与所述vWF碎片粘附到的亲和层析介质接触来分离所述污染物; 在变性剂存在下，从所述亲和层析介质中洗脱所述vWF片段; 并将洗脱的片段与所述变性剂分离，同时将片段的水溶液保持在约2.5至小于约5.5的pH，以增加所述片段的单体化和降低聚集，由此形成vWF片段的水溶液，其为 基本上不含聚集体。
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