公开(公告)号：US20070184122A1

公开(公告)日：2007-08-09

申请号：US11735215

申请日：2007-04-13

申请人： Chad Johnson ,  Edith Nihsen ,  David Zopf ,  Abram Janis

发明人： Chad Johnson ,  Edith Nihsen ,  David Zopf ,  Abram Janis

IPC分类号： A61K35/37 ,  A61K31/727 ,  A61K38/18

CPC分类号： A61L27/3687 ,  A61K31/727 ,  A61K35/38 ,  A61K38/18 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3683

摘要： Described are modified submucosa and other extracellular matrix materials incorporating an amount of bound, exogenous fibronectin. Further described are such materials also having an amount of exogenous heparin bound to the exogenous fibronectin, and also potentially an amount of an exogenous bioactive material, such as a growth factor, bound to the exogenous heparin. Such materials may be used in methods for the treatment of wounds in patients.

摘要翻译： 描述了掺入一定量的结合的外源性纤连蛋白的修饰的粘膜下层和其它细胞外基质材料。 还描述了这样的材料，其也具有与外源性纤连蛋白结合的外源性肝素的量，并且还可能含有与外源性肝素结合的一定量的外源性生物活性物质，例如生长因子。 这些材料可用于治疗患者伤口的方法。

公开(公告)号：US6001819A

公开(公告)日：1999-12-14

申请号：US54890

申请日：1998-04-03

申请人： Paul M. Simon ,  David Zopf ,  Roger A. Barthelson ,  Karl F. Johnson

发明人： Paul M. Simon ,  David Zopf ,  Roger A. Barthelson ,  Karl F. Johnson

IPC分类号： C12P19/26 ,  A61K9/12 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/715 ,  A61P11/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  C07H3/06 ,  C07H5/04 ,  C07H7/027 ,  A01N43/04

CPC分类号： A61K31/702 ,  A61K31/715 ,  C07H3/06 ,  Y10S514/885

摘要： The present invention is directed to compositions for the treatment of respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenza, Burkholderia (Pseudomonas) cepacia, and a mixture thereof, comprising a binding inhibiting effective amount of the compound of Formula I, ##STR1## where R.sub.1 is H, (.beta.-1)GalNAc-, SO.sub.3 B (where B is H or a cation) or a sialic acid of Formula II; ##STR2## where R.sub.6, R.sub.7, R.sub.8, and R.sub.10 are each independently H, C.sub.1-6 acyl, lactyl, C.sub.1-6 alkyl, sulfate, phosphate, anhydro, a sialic acid of Formula II, (.alpha.-1)Fuc, (.beta.-1)Glc or (.beta.-1)Gal;R.sub.9 is NH--C.sub.1-6 acyl, glycolylamido, amino or hydroxyl; andA is H or a cation;R.sub.2 is H or (.alpha.-1)Fuc-;R.sub.3 and R.sub.4 are each independently OH or NHAc;R.sub.5 is H, SO.sub.3 B (where B is H or a cation), or a sialic acid of Formula II as defined above; ##STR3## Y is a chemical bond or a linking group; Z is H or a multivalent support;m is 0 or 1; andp is an integer of 1 to 1,000; with the proviso that the compound is not Gal.beta.1-4-GlcNAc.beta.1-3-Gal.beta.1-4-Glc.

摘要翻译： 本发明涉及用于治疗由选自肺炎链球菌，流感嗜血杆菌，副流感病毒，伯克霍尔德氏菌（Pseudomonas））洋葱的细菌及其混合物引起的呼吸道感染的组合物，其包含结合抑制 式（I）化合物，其中R1为H，（β-1）GalNAc-，SO3B（其中B为H或阳离子）或式Ⅱ的唾液酸; 其中R 6，R 7，R 8和R 10各自独立地为H，C 1-6酰基，乳酰基，C 1-6烷基，硫酸酯，磷酸酯，脱水，式II的唾液酸，（α-1）Fuc，（β-1 ）Glc或（β-1）Gal; R9是NH-C1-6酰基，乙酰氨基，氨基或羟基; A为H或阳离子; R2是H或（α-1）Fuc-; R3和R4各自独立地为OH或NHAc; R5是H，SO3B（其中B是H或阳离子）或如上定义的式II的唾液酸; Y是化学键或连接基团; Z是H或多价载体; m为0或1; p为1〜1000的整数。 条件是该化合物不是Galβ1-4-GlcNAcβ1-3-Galβ1-4-Glc。