公开(公告)号：US08368038B2

公开(公告)日：2013-02-05

申请号：US12552079

申请日：2009-09-01

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/00

CPC classification number: G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  H05H7/04 ,  H05H7/12

Abstract: The invention comprises intensity control of a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Particularly, intensity of a charged particle stream of a synchrotron is described. Intensity control is described in combination with turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements of the synchrotron. The system reduces the overall size of the synchrotron, provides a tightly controlled proton beam, directly reduces the size of required magnetic fields, directly reduces required operating power, and allows continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速度，提取和/或靶向方法和装置的强度控制。 特别地，描述了同步加速器的带电粒子流的强度。 强度控制与旋转磁体，边缘聚焦磁铁，集中磁场磁体，绕组和控制线圈以及同步加速器的提取元件相结合来描述。 该系统减小同步加速器的总体尺寸，提供严格控制的质子束，直接减小所需磁场的尺寸，直接降低所需的操作功率，并且允许在同步加速器中质子的连续加速，即使在从质子中提取质子的过程中 同步加速器

公开(公告)号：US08089054B2

公开(公告)日：2012-01-03

申请号：US12499669

申请日：2009-07-08

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H13/04 ,  A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H7/04 ,  H05H7/10

Abstract: The invention comprises a charged particle beam acceleration and/or extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速和/或提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率，并且允许连续加速 甚至在从同步加速器提取质子的过程中同步加速器中的质子。

公开(公告)号：US20110284761A1

公开(公告)日：2011-11-24

申请号：US13196720

申请日：2011-08-02

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14 ,  H05H13/04

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle cancer therapy system or synchrotron system using a single power supply electrically connected to a plurality of magnet sections to provide a uniform current to a plurality of magnets at a given period in time. Optionally, one or more switches introduce a corresponding one or more resistors into a circuit linking the power supply to a magnet or an inductor during an applied power recovery phase between acceleration cycles of the synchrotron, which reduces time of reduction in power from an active applied power to a power suitable for use with a subsequent injection of charged particles into the synchrotron.

Abstract translation: 本发明包括带电粒子癌症治疗系统或同步加速器系统，其使用电连接到多个磁体部分的单个电源，以在给定的时间段内向多个磁体提供均匀的电流。 可选地，一个或多个开关将相应的一个或多个电阻器引入到在同步加速器的加速循环之间的施加的功率恢复阶段期间将电源连接到磁体或电感器的电路中，从而减少来自主动施加的功率的时间 功率适用于随后将带电粒子注入同步加速器中的功率。

公开(公告)号：US20110278477A1

公开(公告)日：2011-11-17

申请号：US13100102

申请日：2011-05-03

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

Abstract translation: 本发明包括X射线系统，该X射线系统被定向以提供与质子治疗束相同的取向的患者的X射线图像，与患者呼吸同步，可对位于质子治疗的患者进行操作，并且 不干扰质子束处理路径。 优选地，同步系统与负离子束源，同步加速器和/或靶向方法装置结合使用以提供与患者呼吸定时并在颗粒束治疗照射之前和/或同时进行的X射线，以确保 靶向和受控的相对于患者位置的能量传递，导致使用质子束位置验证系统以最小化对患者周围健康组织的损伤的最小化对固体癌性肿瘤的有效，精确和/或准确的非侵入性，体内治疗 。

公开(公告)号：US08045679B2

公开(公告)日：2011-10-25

申请号：US12492216

申请日：2009-06-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H01J35/14

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的X射线方法和装置。 该系统使用位于与粒子束癌治疗系统的质子束路径基本上相同的路径上的X射线束。 该系统产生电子束，该电子束撞击X射线产生源，其中X射线产生源位于质子束路径附近。 通过在质子束路径附近产生X射线，产生基本上是质子束路径的X射线路径。 使用生成的X射线，系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US07943913B2

公开(公告)日：2011-05-17

申请号：US12567901

申请日：2009-09-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H01J3/04 ,  H01J27/028 ,  H05H7/04 ,  H05H13/04

Abstract: The invention comprises a negative ion source method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The negative ion source preferably includes an inlet port for injection of hydrogen gas into a high temperature plasma chamber. In one embodiment, the plasma chamber includes a magnetic material, which provides a magnetic field barrier between the high temperature plasma chamber and a low temperature plasma region on the opposite side of the magnetic field barrier. An extraction pulse is applied to a negative ion extraction electrode to pull the negative ion beam into a negative ion beam path, which proceeds through a first partial vacuum system, through an ion beam focusing system, into the tandem accelerator, and into a synchrotron.

Abstract translation: 本发明包括负离子源方法和用作离子束注入系统的一部分的装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 负离子源优选包括用于将氢气注入高温等离子体室的入口。 在一个实施例中，等离子体室包括磁性材料，其在高温等离子体室与磁场屏障的相对侧上的低温等离子体区域之间提供磁场屏障。 将提取脉冲施加到负离子提取电极，以将负离子束拉入负离子束路径，其通过第一部分真空系统通过离子束聚焦系统进入串联加速器，并进入同步加速器。

公开(公告)号：US20100171447A1

公开(公告)日：2010-07-08

申请号：US12711609

申请日：2010-02-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H05H13/04 ,  A61N5/01

CPC classification number: A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to treatment of solid cancers and more particularly to a method and apparatus correlating proton beam intensity with proton delivery efficiency, optionally in a raster beam scanning system. The system induces betatron oscillation on the proton beam causing the beam to traverse an extraction material resulting in slowed protons and a feedback current proportional to the proton flux. A controller receives the desired intensity from an irradiation plan and the feedback current and adjusts the radio-frequency field in the radio-frequency cavity system to yield an intensity of the proton beam that matches the desired intensity from the irradiation plan. Preferably, the intensity of the proton beam correlates with radiation delivery efficiency. The system preferably operates in conjunction with a multi-field charged particle cancer therapy system, with charged particle beam injection, particle beam acceleration, multi-axis charged particle beam control, and/or targeting methods and apparatus.

Abstract translation: 本发明涉及治疗固体癌症，更具体地涉及将质子束强度与质子传递效率相关联的方法和装置，可选地在光栅束扫描系统中。 该系统引起质子束上的贝塔振荡，导致光束穿过提取材料，导致质子减慢，反馈电流与质子通量成比例。 控制器从照射计划和反馈电流接收期望的强度，并且调整射频腔系统中的射频场，以产生与照射计划匹配所需强度的质子束的强度。 优选地，质子束的强度与辐射传递效率相关。 该系统优选与具有带电粒子束注入，粒子束加速，多轴带电粒子束控制和/或靶向方法和装置的多场带电粒子癌治疗系统结合操作。

公开(公告)号：US20100014640A1

公开(公告)日：2010-01-21

申请号：US12571589

申请日：2009-10-01

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61N5/00 ,  H01J1/50

CPC classification number: H01J3/04 ,  A61N2005/1087 ,  H01J27/028 ,  H05H7/04 ,  H05H13/04

Abstract: The invention comprises a negative ion beam source vacuum method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The negative ion beam source contains a vacuum chamber isolated by a vacuum barrier from the vacuum tube of the synchrotron. The negative ion beam source vacuum system preferably includes: a first pump turbo molecular pump, a large holding volume, and a semi-continuously operating pump. By only pumping ion beam source vacuum chamber and by only semi-continuously operating the ion beam source vacuum based on sensor readings about the holding volume, the lifetime of the semi-continuously operating pump is extended.

Abstract translation: 本发明包括负离子束源真空方法和用作离子束注入系统的一部分的装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 负离子束源包含由真空隔离层从同步加速器的真空管隔离的真空室。 负离子束源真空系统优选包括：第一泵涡轮分子泵，大保持体积和半连续运行的泵。 通过仅泵浦离子束源真空室，并且仅基于关于保持体积的传感器读数半连续地操作离子束源真空，半连续操作泵的寿命延长。

公开(公告)号：US20090309038A1

公开(公告)日：2009-12-17

申请号：US12425683

申请日：2009-04-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14 ,  A61N5/00

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce betatron oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束提取方法和装置。 该系统使用射频（RF）空腔系统来诱导带电粒子流的贝塔振荡。 带电粒子流的足够的幅度调制导致带电粒子流撞击诸如箔的材料。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，以允许从原始带电粒子流物理分离还原能带电粒子流。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US20200227227A1

公开(公告)日：2020-07-16

申请号：US16831749

申请日：2020-03-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J27/20 ,  A61N5/10 ,  G21K1/093

Abstract: The invention comprises a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.