公开(公告)号：US11951329B2

公开(公告)日：2024-04-09

申请号：US16996724

申请日：2020-08-18

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10 ,  A61B6/00 ,  A61B6/02 ,  A61B6/03 ,  A61B6/40 ,  A61B6/42 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

CPC分类号： A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04 ,  A61N2005/1054 ,  A61N5/107 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097

摘要： The invention relates to a method and apparatus for determining actual points along a positively charged particle beam path and/or vectors of the charged particle beam path, where the determined points and vectors aid tomographic construction of a three-dimensional image of a tumor and surrounding tissue. Further, the determined points and vectors of the positively charged particle beam are used in beam control safety, to modify a tumor treatment plan in real time, and/or in combination with co-gathered X-ray images to form a hybrid proton tomography—X-ray three-dimensional image. Preferably, common elements, such as an injector, accelerator, beam transport system, and/or patient positioning system are used for both tumor treatment and tumor imaging.

公开(公告)号：US09737731B2

公开(公告)日：2017-08-22

申请号：US15157263

申请日：2016-05-17

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： H05H15/00 ,  A61N5/10 ,  A61B6/02 ,  A61B6/00 ,  A61B6/03 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

CPC分类号： A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1044 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

摘要： The invention relates to a method and apparatus of control and/or determination of energy and/or velocity of a beam of a charged particles extracted from a synchrotron, the synchrotron using a radio frequency field to redirect the charged particles through an extraction material. The method and apparatus for extracting a group of charged particles at a known and controlled energy is optionally used in conjunction with any apparatus and/or technique coupled to a synchrotron, such as a charged particle cancer therapy system. For example, the knowledge/control of the charged particle beam delivery energy is used in conjunction with a multi-axes and/or a multi-field tumor irradiation system in combination with a tumor treatment plan to accurately ablate or irradiate a tumor.

公开(公告)号：US20160155597A1

公开(公告)日：2016-06-02

申请号：US14860577

申请日：2015-09-21

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： H01J27/20 ,  A61N5/10

CPC分类号： H01J27/20 ,  A61N5/1077 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

摘要： A charged particle cancer therapy system is used to accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. A first example of an electron extraction subsystem is a hydrogen gas electron stripping system. A second example of an electron extraction subsystem is a carbon foil electron stripping system. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

公开(公告)号：US20150343238A1

公开(公告)日：2015-12-03

申请号：US14293861

申请日：2014-06-02

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1087 ,  A61N2005/1097

摘要： A patient positioning/constraint apparatus and method of use thereof is described in combination with a charged particle cancer therapy system. In one embodiment, a patient is tilted about a longitudinal axis, such as rotation about a head-to-foot axis of the patient where the head-to-foot axis of the patient is horizontal. Optional side support constraints are optionally used to constrain radial movement of the patient on the tilted patient support. The side support constraints are optionally pre-formed to or coupled to a radially outer shape of an individual patient, such as the dexter or sinister side of the individual's head, arm, torso, hip, and/or leg. Patient tilt is optionally combined with rotation of the patient about a vertical axis, rotation of the entire patient about an axis not overlapped by the patient, and/or dynamic control of angles of incident charged particles directed by beamline magnets of the charged particle therapy system.

摘要翻译： 与带电粒子癌症治疗系统结合描述患者定位/约束装置及其使用方法。 在一个实施例中，患者围绕纵向轴线倾斜，例如围绕患者的头部到脚部轴线的旋转，其中患者的头部到脚部轴线是水平的。 可选的侧支撑约束可选地用于限制患者在倾斜患者支架上的径向运动。 侧支撑约束可选地预先形成为或联接到个体患者的径向外部形状，例如个体头部，手臂，躯干，髋部和/或腿部的屈曲或阴性侧面。 患者倾斜可选地与患者围绕垂直轴的旋转组合，整个患者围绕不与患者重叠的轴的旋转，和/或由带电粒子治疗系统的束线磁体引导的入射带电粒子的角度的动态控制 。

公开(公告)号：US20150283405A1

公开(公告)日：2015-10-08

申请号：US14246803

申请日：2014-04-07

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10

CPC分类号： A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

摘要： A rotatable targeting magnet apparatus and method of use thereof is described where the rotatable targeting magnet rotates independently of a beamline arc at the end of the beamline arc, where the arc is after an accelerator and before the patient in a cancer therapy system. The rotatable targeting magnet directs the charged particle beam, such as vertically, using applied current to the targeting magnet while rotation of the magnet allows scanning across the tumor. Rotation of the patient relative to the charged particle allows distribution of trailing Bragg peak energy within and/or circumferentially about the tumor.

摘要翻译： 描述了一种可旋转靶向磁铁装置及其使用方法，其中可转动的定向磁体独立于束线弧的末端处的光束弧线旋转，其中电弧在加速器之后并且在癌症治疗系统中的患者之前。 可旋转定向磁体通过使用施加的电流将带电粒子束（例如垂直）引导到靶向磁体，同时磁体的旋转允许跨越肿瘤扫描。 患者相对于带电粒子的旋转允许在肿瘤内和/或周向周围分布肿瘤的后布拉格峰能量。

公开(公告)号：US20150273240A1

公开(公告)日：2015-10-01

申请号：US14231020

申请日：2014-03-31

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10 ,  H01J37/141

CPC分类号： A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

摘要： A fast magnet switching method and apparatus used to rapidly redirect cations, such as H+ or C6+, in a beam path, such as during or between treatment of individual volumes or voxels of a tumor of the patient, is described. Switching means include rapidly increasing or decreasing applied current to a coil about a magnet, which rapidly alters a magnetic field crossing the charged particle path and redirects a charged particle beam away from the patient, such as to a charged particle beam stop. Means to rapidly induce the current change include: (1) using a separate high voltage power supply and/or (2) opening a switch to redirect current through a resistor. In both cases, the rapid current change to the coil yields a rapid change the magnetic field and a corresponding rapid change in direction of the charged particles in the charged particle cancer therapy system.

摘要翻译： 描述了用于在诸如患者的肿瘤的个体体积或体素的处理期间或之间的波束路径中快速重定向阳离子（例如H +或C6 +）的快速磁体切换方法和装置。 切换装置包括对围绕磁体的线圈的施加电流迅速增加或减小，其迅速改变穿过带电粒子路径的磁场并将带电粒子束重新定向远离患者，诸如带电粒子束停止。 快速引起电流变化的手段包括：（1）使用单独的高压电源和/或（2）打开开关以使电流重新定向通过电阻器。 在这两种情况下，线圈的快速电流变化都会迅速改变带电粒子癌症治疗系统中带电粒子的磁场和相应的方向快速变化。

公开(公告)号：US08941084B2

公开(公告)日：2015-01-27

申请号：US13887339

申请日：2013-05-05

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： G21K5/04 ,  A61N5/10

CPC分类号： A61N5/107 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

摘要： The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

摘要翻译： 本发明一般涉及固体癌的治疗。 更具体地，描述了用于向肿瘤有效辐射剂量递送的方法和装置。 优选地，辐射通过入口点输送到肿瘤中，并且布拉格峰值能量靶向肿瘤的远端或远侧与进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 光束强度与辐射剂量传递效率成正比。 具有针对每个照射方向的肿瘤远侧的能级的多场照射过程提供均匀且有效的带电粒子辐射剂量递送至肿瘤。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。

公开(公告)号：US20130218009A1

公开(公告)日：2013-08-22

申请号：US13572567

申请日：2012-08-10

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10 ,  A61B6/02

CPC分类号： A61N5/1077 ,  A61B6/02 ,  A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a rapid patient positioning system including a computer and motor controlled patient constraint system, such as a patient head and/or back support system having multiple adjustable degrees of freedom that facilitates accurate, precise, and rapid alignment of a patient relative to a support or table. The patient support system is preferably integrated with a rapid patient positioning system including steps of: positioning a patient relative to the table in a substantially vertical orientation, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and the table in a substantially horizontal orientation, such as in a position for charged particle tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy.

摘要翻译： 本发明包括快速的患者定位系统，其包括计算机和马达控制的患者约束系统，例如具有多个可调节自由度的患者头部和/或后支撑系统，其有助于患者相对于患者的准确，精确和快速对准 支持或表。 患者支撑系统优选地与快速患者定位系统集成，包括以下步骤：将患者相对于桌子以基本竖直的方向定位，使得桌子通过诸如机器人手臂的半垂直取向过渡，并使 患者和桌子处于基本水平的方向，例如用于带电粒子肿瘤治疗的位置。 优选地，机器人臂与用于在传统质子治疗中移动患者的手臂相同。

公开(公告)号：US20130217946A1

公开(公告)日：2013-08-22

申请号：US13572542

申请日：2012-08-10

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10 ,  A61B6/04 ,  A61B6/03

CPC分类号： A61N5/10 ,  A61B6/03 ,  A61B6/0421 ,  A61B6/4258 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1069 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session.

摘要翻译： 本发明包括带电粒子束，快速患者定位系统，其包括以下步骤：将患者相对于桌子以基本垂直的方向定位，可选地约束患者具有一个或多个约束的运动，使所述桌子跨过半垂直取向 ，例如用机器人手臂，并且以基本上水平的方向（例如用于肿瘤治疗的位置）使患者和桌子定向。 优选地，机器人臂与用于在传统质子治疗中移动患者的手臂相同。 可选地，机器人手臂用于在带电粒子治疗会话结束时将患者重新定向为基本垂直的取向。

公开(公告)号：US20120209052A1

公开(公告)日：2012-08-16

申请号：US13456840

申请日：2012-04-26

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N2/00

CPC分类号： H05H13/04 ,  H05H7/04

摘要： The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

摘要翻译： 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转动磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈，平面入射磁场表面和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减少 即使在从同步加速器提取质子的过程中，所需磁场的尺寸也能直接降低所需的工作功率，并允许同步加速器中质子的持续加速。