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84 条记录 (耗时 0.06 秒)

    Interwoven dual sinusoidal helix stent
    41.
    发明授权
    Interwoven dual sinusoidal helix stent 失效
    交织双正弦螺旋支架

    公开(公告)号：US5913896A

    公开(公告)日：1999-06-22

    申请号：US887585

    申请日：1997-07-03

    申请人： William J. Boyle ,  Rosalinda A. Wong ,  James M. Shy

    发明人： William J. Boyle ,  Rosalinda A. Wong ,  James M. Shy

    IPC分类号： A61F2/90 ,  A61F2/06 ,  A61M29/00 ,  A61M29/02

    CPC分类号： A61F2/90 ,  Y10S623/901

    摘要： A method and apparatus for a radially expandable stent for implantation within a body vessel, comprising a first and second wire having a series of alternating peaks and valleys. The valleys of the first wire are braided with the peaks of the second wire forming a braided region with the interwoven first and second wire being wound into a continuous helix having a hollow cylindrical shape. The peaks of the first wire of the continuous helix may be welded to the adjacent valleys of the second wire of the continuous helix. The peaks and valleys of the first wire may symmetrically intersect with the peaks and valleys of the second wire to form a uniform series of crossings thereby permitting even expansion of the first and second wires. The proximal end of the first wire may be attached to the proximal end of the second wire. The distal end of the first wire may be attached to the distal end of the second wire. A means within the interwoven first and second wires of the continuous helix may be included for expansion thereof.

    摘要翻译： 一种用于植入体内容器的可径向扩张的支架的方法和装置，包括具有一系列交替的峰和谷的第一和第二线。 第一线的谷被编织，其中第二线的峰形成编织区域，交织的第一和第二线缠绕成具有中空圆柱形状的连续螺旋。 连续螺旋的第一线的峰可以焊接到连续螺旋的第二线的相邻的谷。 第一线的峰和谷可以与第二线的峰和谷对称地相交，以形成均匀的一系列交叉，从而允许第一和第二线的均匀膨胀。 第一线的近端可以附接到第二线的近端。 第一线的远端可以附接到第二线的远端。 可以包括连续螺旋的交织的第一和第二丝线内的装置用于其连续扩张。

    Filtered manifold apparatus and method for ophthalmic irrigation
    42.
    发明授权
    Filtered manifold apparatus and method for ophthalmic irrigation 失效
    过滤式歧管装置和眼科灌洗方法

    公开(公告)号：US4734091A

    公开(公告)日：1988-03-29

    申请号：US88986

    申请日：1987-08-21

    申请人： William J. Boyle ,  Thomas F. Irish

    发明人： William J. Boyle ,  Thomas F. Irish

    IPC分类号： A61F9/007 ,  A61M3/02 ,  A61M5/00

    CPC分类号： A61M3/0241 ,  A61F9/00736 ,  Y10T137/87877

    摘要： An apparatus and a method for opthalmic irrigation provide sterile, filtered irrigation fluid to the eye at high flow rates. The apparatus includes a filter capable of removing particulates on the order of 0.8 microns, and preferably as small as 0.22 microns. A distribution manifold is disclosed whereby fluid from a common reservoir may be routed sequentially to plural recipient sites.

    摘要翻译： 用于眼睛冲洗的装置和方法以高流速向眼睛提供无菌的，过滤的灌洗液。 该装置包括能够去除约0.8微米，优选小至0.22微米的微粒的过滤器。 公开了一种分配歧管，其中来自公共储存器的流体可以顺序地路由到多个接收点。

    Embolic filtering devices
    43.
    发明授权
    Embolic filtering devices 有权
    栓塞过滤装置

    公开(公告)号：US08591540B2

    公开(公告)日：2013-11-26

    申请号：US10675611

    申请日：2003-09-29

    申请人： William J. Boyle ,  John E. Papp ,  Charles R. Peterson ,  Paul F. Muller ,  Donald Schwarten ,  Kathern J. Lind

    发明人： William J. Boyle ,  John E. Papp ,  Charles R. Peterson ,  Paul F. Muller ,  Donald Schwarten ,  Kathern J. Lind

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2/97 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

    摘要： An embolic filtering system includes a guide wire, a filter device disposed on the guide wire, a sheath adapted to maintain the filter device in an unexpanded position and a torque device having a lumen for receiving the guide wire and a locking mechanism for locking the torque device to the guide wire. The torque device may include a side port adapted to receive the proximal end of the sheath to allow a portion of the guide wire to shear the sheath from the guide wire through retraction of the sheath through the side port. The torque device may include an extension arm having a distal opening adapted to receive both the guide wire and the sheath. A second lumen may be used to allow a portion of the guide wire to shear the sheath away from the guide wire through retraction of the sheath through the second lumen.

    摘要翻译： 栓塞过滤系统包括引导线，设置在引导线上的过滤器装置，适于将过滤装置保持在未膨胀位置的护套和具有用于容纳引导线的内腔的扭矩装置和用于锁定扭矩的锁定机构 设备到导丝。 扭矩装置可以包括适于容纳护套的近端的侧端口，以允许导线的一部分通过护套通过侧端部缩回而从引导线剪切护套。 扭矩装置可以包括延伸臂，其具有适于接纳导丝和护套的远端开口。 可以使用第二内腔来允许引导线的一部分通过使护套通过第二内腔缩回而将护套从引导线上剪切。

    Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
    46.
    发明授权
    Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein 有权
    使用抗骨质保护蛋白结合蛋白的方法减少破骨细胞形成或骨吸收

    公开(公告)号：US07923008B2

    公开(公告)日：2011-04-12

    申请号：US11336067

    申请日：2006-01-19

    申请人： William J. Boyle

    发明人： William J. Boyle

    IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/22 ,  A61K38/29

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K2319/30

    摘要： A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.

    摘要翻译： 已经基于其对骨保护素的亲和力，鉴定了参与骨转播成熟的新型多肽，骨保护蛋白结合蛋白。 还描述了编码多肽或其片段，类似物或衍生物的核酸序列，用于产生的载体和宿主细胞，制备骨保护蛋白结合蛋白的方法和结合测定。 还提供了用于治疗骨质疏松症，由于关节炎或转移引起的骨丢失，高钙血症和佩吉特氏病等骨疾病的组合物和方法。

    Osteoprotegerin
    49.
    发明授权
    Osteoprotegerin 失效
    骨保护素

    公开(公告)号：US06369027B1

    公开(公告)日：2002-04-09

    申请号：US08706945

    申请日：1996-09-03

    申请人： William J. Boyle ,  David L. Lacey ,  Frank J. Calzone ,  Ming-Shi Chang

    发明人： William J. Boyle ,  David L. Lacey ,  Frank J. Calzone ,  Ming-Shi Chang

    IPC分类号： A61K3818

    CPC分类号： C07K14/70578 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.

    摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。

    Diagnostic sheath for reduced embolic risk
    50.
    发明授权
    Diagnostic sheath for reduced embolic risk 有权
    诊断护套

    公开(公告)号：US06306106B1

    公开(公告)日：2001-10-23

    申请号：US09596873

    申请日：2000-06-19

    申请人： William J. Boyle

    发明人： William J. Boyle

    IPC分类号： A61B500

    CPC分类号： A61M25/0068 ,  A61M25/0662

    摘要： This invention is directed to a diagnostic sheath device which is adapted to facilitate atraumatic navigation of intravascular catheters along vascular pathways. The sheath consists of an elongated flexible shaft, having a proximal end and a distal end. The distal end of the shaft is hemispherically-shaped or elongated. A guide wire lumen extends through the shaft, from the proximal end to the distal end, for receiving a guide wire. At least one dye-injection lumen extends through the elongated shaft from the proximal end and joins the guide wire lumen at a point near the distal end of the shaft to provide fluid communication between the injection lumen and the guide wire lumen. The shaft is slidably inserted through the hollow interior of a guide catheter so that the hemispherically-shaped or elongated distal end of the shaft extends beyond the distal end of the guide catheter. Thus, the hemispherically-shaped or elongated distal end cooperates with the guide catheter body to provide a smooth rounded catheter tip which, when advanced along the patient's vasculature, reduces the risk of causing trauma to the blood vessel, freeing plaque from the vessel wall, or creating embolisms in the bloodstream.

    摘要翻译： 本发明涉及一种诊断护套装置，其适于促进沿着血管通路的血管内导管的无损伤导航。 护套由细长的柔性轴组成，具有近端和远端。 轴的远端是半球形或细长的。 导丝腔从基端延伸到远端，用于接收导丝。 至少一个染料注射腔从近端延伸穿过细长轴并且在靠近轴的远端的点处连接导丝管腔，以在注射腔和导丝管腔之间提供流体连通。 轴可滑动地插入穿过引导导管的中空内部，使得轴的半球形或细长的远端延伸超过引导导管的远端。 因此，半球形或细长的远端与引导导管主体配合以提供平滑的圆形导管末端，当沿着患者的脉管系统前进时，导管尖端减小了对血管造成创伤的风险，从血管壁释放斑块， 或在血液中产生栓塞。