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公开(公告)号：US07632922B1
公开(公告)日：2009-12-15
申请号：US09718725
申请日：2000-11-22
CPC分类号： C07K16/2878 , C07K14/70578 , C07K2319/30 , G01N2333/7151
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US06613544B1
公开(公告)日：2003-09-02
申请号：US08577788
申请日：1995-12-22
IPC分类号： C07K1451
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06288032B1
公开(公告)日：2001-09-11
申请号：US08795446
申请日：1997-02-06
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor super family and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06284728B1
公开(公告)日：2001-09-04
申请号：US08795447
申请日：1997-02-06
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US06284485B1
公开(公告)日：2001-09-04
申请号：US08795445
申请日：1997-02-06
IPC分类号： C12N121
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06284740B1
公开(公告)日：2001-09-04
申请号：US08974186
申请日：1997-11-18
IPC分类号： A01N4304
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US6015938A
公开(公告)日：2000-01-18
申请号：US974022
申请日：1997-11-18
IPC分类号： A01K67/027 , A61K35/74 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/15 , G01N33/53 , C12N5/00
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US06369027B1
公开(公告)日：2002-04-09
申请号：US08706945
申请日：1996-09-03
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US20100298229A1
公开(公告)日：2010-11-25
申请号：US12637722
申请日：2009-12-14
CPC分类号： C07K16/2878 , C07K14/70578 , C07K2319/30 , G01N2333/7151
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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