公开(公告)号：US20170334902A1

公开(公告)日：2017-11-23

申请号：US15600490

申请日：2017-05-19

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, JR. ,  Alla Yurevna Zenova

IPC: C07D451/06 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D451/06 ,  C07D213/76 ,  C07D237/20 ,  C07D239/69 ,  C07D261/16 ,  C07D277/52 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

公开(公告)号：US20170114075A1

公开(公告)日：2017-04-27

申请号：US15253369

申请日：2016-08-31

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Mikhail Chafeev ,  Sultan Chowdhury ,  Lauren Fraser ,  Jianmin Fu ,  Jonathan Langille ,  Shifeng Liu ,  Jianyu Sun ,  Shaoyi Sun ,  Serguei Sviridov ,  Mark Wood ,  Alla Yurevna Zenova ,  Qi Jia ,  Jean-Jacques Alexandre Cadieux ,  Simon J. Gauthier ,  Amy Frances Douglas ,  Tom Hsieh ,  Nagasree Chakka ,  Zoran Cikojevic

IPC: C07D513/22 ,  C07D491/20 ,  C07D495/20 ,  C07D498/20 ,  C07D491/22 ,  C07D513/20 ,  C07D491/107

CPC classification number: C07D513/22 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20 ,  C07D491/22 ,  C07D495/20 ,  C07D498/20 ,  C07D513/20 ,  C07D519/00

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.