公开(公告)号：US20080140150A1

公开(公告)日：2008-06-12

申请号：US11751813

申请日：2007-05-22

申请人： Xiaohong Zhou ,  Thomas J. Mullen ,  Gary W. King ,  Michael R.S. Hill

发明人： Xiaohong Zhou ,  Thomas J. Mullen ,  Gary W. King ,  Michael R.S. Hill

IPC分类号： A61N1/05

CPC分类号： A61N1/36071 ,  A61N1/205 ,  A61N1/36021

摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes

摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维

公开(公告)号：US20070213773A1

公开(公告)日：2007-09-13

申请号：US11748847

申请日：2007-05-15

申请人： Michael Hill ,  Gary King ,  Thomas Mullen ,  Xiaohong Zhou

发明人： Michael Hill ,  Gary King ,  Thomas Mullen ,  Xiaohong Zhou

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/0504 ,  A61N1/36585

摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the patient's body, and then the physiologic response of the patient is monitored to determine the efficacy of the stimulation.

摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将电刺激递送到患者体内神经系统的一个或多个预定部分; 并监测身体的一个或多个生理指标以确定递送的治疗是否有效。 也就是说，使用闭环反馈控制器对患者身体的预选区域施加电刺激，然后监测患者的生理反应以确定刺激的功效。

公开(公告)号：US07218964B2

公开(公告)日：2007-05-15

申请号：US10035319

申请日：2001-10-26

申请人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

发明人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

IPC分类号： A61N1/372

CPC分类号： A61N1/36114 ,  A61N1/3627

摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering closed loop electrical stimulation to one or more predetermined portions of a portion of excitable tissue of the spinal cord of a patient; and monitoring one or more physiologic indices of the body. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the spinal cord of a patient's body based upon one or more aspects of the physiologic indices.

摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将闭环电刺激递送到患者脊髓的可激发组织的一部分的一个或多个预定部分; 并监测身体的一个或多个生理指标。 也就是说，使用闭环反馈控制器基于生理指标的一个或多个方面对患者身体的脊髓的预选区域施加电刺激。

公开(公告)号：US20060116592A1

公开(公告)日：2006-06-01

申请号：US11186552

申请日：2005-07-21

申请人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

发明人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0422 ,  A61N1/365 ,  A61N1/3702 ,  A61N1/37258

摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.

公开(公告)号：US07010345B2

公开(公告)日：2006-03-07

申请号：US09999723

申请日：2001-10-26

申请人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

发明人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

IPC分类号： A61N1/18

CPC分类号： A61N1/36114 ,  A61N1/3627

摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.

公开(公告)号：US06369568B1

公开(公告)日：2002-04-09

申请号：US09325081

申请日：1999-06-03

申请人： Jingfei Ma ,  Xiaohong Zhou

发明人： Jingfei Ma ,  Xiaohong Zhou

IPC分类号： G01V300

CPC分类号： G01R33/56554 ,  G01R33/5617

摘要： A prescan process for an MR fast spin echo (FSE) pulse sequence adjusts the phases of the RF excitation pulse and RF refocusing pulses in the FSE pulse sequence to reduce the spatially invariant phase errors (zeroth order). The prescan process also calculates the value of a readout gradient compensation pulse, a phase-encoding gradient compensation pulse and a slice-select gradient compensation pulse to reduce the first order phase shifts along the readout, phase-encoding, and slice-select gradient axes.

摘要翻译： 用于MR快速自旋回波（FSE）脉冲序列的预扫描过程调整FSE脉冲序列中RF激励脉冲和RF重聚焦脉冲的相位，以减少空间不变相位误差（零级）。 预扫描过程还计算读出梯度补偿脉冲的值，相位编码梯度补偿脉冲和切片选择梯度补偿脉冲，以减少沿着读出，相位编码和切片选择梯度轴的一阶相移 。

公开(公告)号：US06239599B1

公开(公告)日：2001-05-29

申请号：US09316344

申请日：1999-05-21

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

IPC分类号： G01V300

CPC分类号： G01R33/58 ,  G01R33/56518 ,  G01R33/56554

摘要： A technique is disclosed for determining errors in MRI sequences resulting from eddy currents generated by pulsed gradient fields. During a calibration sequence, with no phase-encoding, gradient pulses and readout sequences are applied along physical axes of a scanner and data sets are acquired for each combination. A reference data set is acquired with no gradient pulses applied. The resulting data sets are processed by one dimensional Fourier transformation, and the transformed data is analyzed to determine spatially invariant and linear gradient errors. The phase errors may be averaged for each physical axis. The technique is particularly useful in determining errors in diffusion weighted echo planar imaging sequences.

摘要翻译： 公开了一种用于确定由脉冲梯度场产生的涡流产生的MRI序列中的误差的技术。 在校准序列期间，没有相位编码，沿着扫描仪的物理轴施加梯度脉冲和读出序列，并为每个组合采集数据集。 在不施加梯度脉冲的情况下获取参考数据集。 通过一维傅里叶变换处理所得到的数据集，并分析变换数据以确定空间不变和线性梯度误差。 每个物理轴可以对相位误差进行平均。 该技术在确定扩散加权回波平面成像序列中的误差方面特别有用。

公开(公告)号：US6057685A

公开(公告)日：2000-05-02

申请号：US987594

申请日：1997-12-09

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： G01R33/567 ,  G01V3/00

CPC分类号： G01R33/56509 ,  G01R33/5676

摘要： In a method for providing an MR image of a section taken through an object, wherein the section is acquired in the presence of in-plane translational motion of the object, an MR system is operated to acquire a set of imaging data points from the section, the set of imaging data points being contaminated by phase errors resulting from the motion. The MR system is further operated to acquire a plurality of correction data point sets, each correction data point in one of said sets being acquired along an alignment line or other trajectory and at a location coinciding with the location of one of the imaging data points. The imaging data points respectively coinciding with the correction data points comprise, collectively, a subset of the imaging data points. The phase difference between each correction data point set and its corresponding subset of imaging data points is determined, and then used to remove the phase errors from the set of imaging data points.

摘要翻译： 在用于提供通过对象拍摄的部分的MR图像的方法中，其中在存在对象的平面内平移运动的情况下获取该部分，操作MR系统以从该部分获取一组成像数据点 ，该组成像数据点被运动产生的相位误差污染。 进一步操作MR系统以获取多个校正数据点集合，其中一个组中的每个校正数据点沿着对准线或其他轨迹以及与一个成像数据点的位置重合的位置获取。 分别与校正数据点一致的成像数据点总共包括成像数据点的子集。 确定每个校正数据点集合及其对应的成像数据点子集之间的相位差，然后用于从成像数据点集合中去除相位误差。

公开(公告)号：US6011392A

公开(公告)日：2000-01-04

申请号：US5768

申请日：1998-01-12

申请人： Xiaohong Zhou ,  Matthew A. Bernstein ,  Gousheng Tan

发明人： Xiaohong Zhou ,  Matthew A. Bernstein ,  Gousheng Tan

IPC分类号： G01R33/561 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56581 ,  G01R33/56554 ,  G01R33/5617

摘要： Fast spin echo pulse sequences are adjusted to reduce, or eliminate image artifacts caused by Maxwell terms arising from the linear imaging gradients. The waveforms of the slice selection, phase encoding and readout gradients are adjusted in shape, size or position to eliminate or reduce the phase error caused by the spatially quadratic Maxwell terms.

摘要翻译： 调整快速自旋回波脉冲序列以减少或消除由线性成像梯度引起的麦克斯韦术引起的图像伪像。 切片选择，相位编码和读出梯度的波形在形状，大小或位置上进行调整，以消除或减少由空间二次Maxwell项引起的相位误差。

公开(公告)号：US5689186A

公开(公告)日：1997-11-18

申请号：US577000

申请日：1995-12-26

申请人： Joseph Kenneth Maier ,  Frederick Howard Epstein ,  Xiaohong Zhou ,  Lawrence Edward Ploetz ,  Paul E. Licato

发明人： Joseph Kenneth Maier ,  Frederick Howard Epstein ,  Xiaohong Zhou ,  Lawrence Edward Ploetz ,  Paul E. Licato

IPC分类号： G01R33/54 ,  G01V3/00

CPC分类号： G01R33/4833

摘要： An off-center NMR image is produced using an EPI pulse sequence. The offset along the readout gradient axis is achieved by shifting the frequency of an RF reference signal used to demodulate the received NMR echo signals. Phase errors produced by the NMR system and by the shifts in reference signal frequency are corrected in "real time" by also shifting the phase of the RF reference signal.

摘要翻译： 使用EPI脉冲序列产生偏心NMR图像。 沿读出梯度轴的偏移量通过移位用于解调所接收的NMR回波信号的RF参考信号的频率来实现。 由NMR系统产生的相位误差和参考信号频率的偏移通过也移动RF参考信号的相位而以“实时”校正。