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公开(公告)号：US07155278B2
公开(公告)日：2006-12-26
申请号：US10419405
申请日：2003-04-21
申请人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
发明人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36017 , A61N1/36114
摘要： Neurostimulation is delivered to one or more predetermined locations on or within a patient in order to treat effects of sleep apnea by modulating autonomic nervous activity. Delivery of neurostimulation at predetermined locations can decrease sympathetic nervous activity and/or increase parasympathetic nervous activity, countering the increased intrinsic sympathetic activity associated with apnea-arousal cycles. In some embodiments, neurostimulation is delivered to the spinal cord of the patient via an implanted electrode. In other embodiments, neurostimulation is delivered transcutaneously to the spinal cord or other locations via electrodes located on the surface of the patient. In some embodiments, delivery of neurostimulation is initiated or modified in response to detection of apneas.
摘要翻译： 神经刺激被递送到患者体内或患者内的一个或多个预定位置，以通过调节自主神经活动来治疗睡眠呼吸暂停的影响。 在预定位置递送神经刺激可降低交感神经活动和/或增加副交感神经活动，抵抗与呼吸暂停 - 觉醒周期相关的增加的内在交感神经活动。 在一些实施方案中，神经刺激经由植入的电极递送至患者的脊髓。 在其他实施方案中，神经刺激通过位于患者表面上的电极经皮递送至脊髓或其它位置。 在一些实施方案中，响应于呼吸暂停的检测开始或修饰神经刺激的递送。
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公开(公告)号：US07221979B2
公开(公告)日：2007-05-22
申请号：US10426610
申请日：2003-04-30
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7–L2 and the associated neural fibers within a region of the T7–L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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公开(公告)号：US09656079B2
公开(公告)日：2017-05-23
申请号：US12565910
申请日：2009-09-24
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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公开(公告)号：US07650190B2
公开(公告)日：2010-01-19
申请号：US11751813
申请日：2007-05-22
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括但不限于在T7-L2皮层区域内的T7-L2级和相关神经纤维的脊髓。
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公开(公告)号：US08417334B2
公开(公告)日：2013-04-09
申请号：US10039307
申请日：2001-10-26
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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6.发明授权Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置公开(公告)号：US07672733B2
公开(公告)日：2010-03-02
申请号：US11116970
申请日：2005-04-28
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。
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7.发明授权公开(公告)号：US07218964B2
公开(公告)日：2007-05-15
申请号：US10035319
申请日：2001-10-26
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering closed loop electrical stimulation to one or more predetermined portions of a portion of excitable tissue of the spinal cord of a patient; and monitoring one or more physiologic indices of the body. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the spinal cord of a patient's body based upon one or more aspects of the physiologic indices.
摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将闭环电刺激递送到患者脊髓的可激发组织的一部分的一个或多个预定部分; 并监测身体的一个或多个生理指标。 也就是说，使用闭环反馈控制器基于生理指标的一个或多个方面对患者身体的脊髓的预选区域施加电刺激。
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公开(公告)号：US07010345B2
公开(公告)日：2006-03-07
申请号：US09999723
申请日：2001-10-26
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.
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9.发明申请METHOD AND APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC CONDITIONS 有权用于电刺激神经系统以改善心脏功能障碍，心脏衰竭和其他心脏病症的方法和装置公开(公告)号：US20100016919A1
公开(公告)日：2010-01-21
申请号：US12565910
申请日：2009-09-24
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
摘要翻译： 使用方法和装置为患有心室功能障碍或心力衰竭的患者提供治疗。 至少一个电极位于与患者体内的神经组织如神经束T1-T4相关联的区域中。 电刺激被施加到至少一个电极以改善患者心脏的心脏效率。 监测患者的一个或多个预定生理参数，并且基于一个或多个预定生理参数来调整电刺激。
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公开(公告)号：US20080140150A1
公开(公告)日：2008-06-12
申请号：US11751813
申请日：2007-05-22
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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