公开(公告)号：US4883800A

公开(公告)日：1989-11-28

申请号：US130297

申请日：1987-12-08

申请人： Masashi Hashimoto ,  Teruo Oku ,  Yoshikuni Ito ,  Takayuki Namiki ,  Kozo Sawada ,  Chiyoshi Kasahara ,  Yukihisa Baba

发明人： Masashi Hashimoto ,  Teruo Oku ,  Yoshikuni Ito ,  Takayuki Namiki ,  Kozo Sawada ,  Chiyoshi Kasahara ,  Yukihisa Baba

IPC分类号： C12N9/99 ,  A61K31/505 ,  A61K31/517 ,  A61K31/54 ,  A61K31/5415 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P27/02 ,  A61P27/12 ,  A61P43/00 ,  C07D239/80 ,  C07D239/91 ,  C07D239/93 ,  C07D239/95 ,  C07D239/96 ,  C07D265/26 ,  C07D285/24 ,  C07D401/06 ,  C07D409/06 ,  C07D521/00

CPC分类号： C07D401/06 ,  C07D239/95 ,  C07D239/96 ,  C07D285/24 ,  C07D409/06

摘要： The invention relates to compounds having aldose reductase-inhibitory activity of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,R.sup.3 is phenyl(lower)alkyl which may have one or more substituent(s) selected from the group consisting of halogen, lower alkoxy, halo(lower)alkyl and lower alkyl,R.sup.4 is carboxy or protected carboxy,A is sulfur atom,Y is carbonyl, thiocarbonyl or sulfonyl andZ is lower alkylene,and pharmaceutically acceptable salts thereof, useful in treating diabetic complications.