公开(公告)号：US20070149514A1

公开(公告)日：2007-06-28

申请号：US10539707

申请日：2003-12-24

Applicant: Michael Woltering ,  Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Heike Heckroth ,  Michael Otteneder

Inventor： Michael Woltering ,  Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Heike Heckroth ,  Michael Otteneder

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/405 ,  C07D403/02 ,  C07D413/02 ,  C07D417/02

CPC classification number: C07D417/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14

Abstract: The invention relates to novel indole-phenylfulfonamide derivatives, to methods for the production thereof, and to their use in medicaments, particularly as potent PPAR-delta activating compounds, for the prevention and/or treatment of cardiovascular diseases, particularly dyslipidemias and coronary heart diseases.

Abstract translation: 本发明涉及新的吲哚 - 苯氟虫酰胺衍生物，其生产方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病，特别是血脂异常和冠心病的药物 。

公开(公告)号：US20070105881A1

公开(公告)日：2007-05-10

申请号：US10559954

申请日：2004-06-16

Applicant: Martin Hendrix ,  Lars Barfacker ,  Bettina Beyreuther ,  Ulrich Ebert ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Yan-Hong Liu ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Barfacker ,  Bettina Beyreuther ,  Ulrich Ebert ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Yan-Hong Liu ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/513 ,  C07D239/14

CPC classification number: C07D239/42 ,  C07D401/12 ,  C07D409/12

Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.

Abstract translation: 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。

公开(公告)号：US20050154061A1

公开(公告)日：2005-07-14

申请号：US10492761

申请日：2002-10-09

Applicant: Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Heike Heckroth ,  Andrea Vaupel ,  Michael Woltering ,  Stefan Weigand

Inventor： Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Heike Heckroth ,  Andrea Vaupel ,  Michael Woltering ,  Stefan Weigand

IPC: A61K31/196 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C217/58 ,  C07C231/12 ,  C07C237/04 ,  C07C237/06 ,  C07C319/20 ,  C07C323/52 ,  A61K31/195 ,  C07C233/51

CPC classification number: C07C323/52 ,  C07C217/58 ,  C07C237/04 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18

Abstract: The present invention relates to novel substituted acetic acid derivatives, to processes for their preparation and to their use in medicaments, in particular as potent PPAR-delta-activating compounds for the prophylaxis and/or treatment of cardiovascular disorders, in particular dyslipidaemias and coronary heart diseases.

Abstract translation: 本发明涉及新的取代的乙酸衍生物，其制备方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病，特别是血脂异常和冠心病的有效的PPAR-δ-活化化合物 疾病