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公开(公告)号：US20070254960A1
公开(公告)日：2007-11-01
申请号：US11741420
申请日：2007-04-27
申请人： Petra Bloms-Funke , Klaus Schiene
发明人： Petra Bloms-Funke , Klaus Schiene
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K31/133 , A61K31/167 , A61K2300/00
摘要： A combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) Paracetamol or a derivative thereof, a pharmaceutical formulation and a dosage form comprising said combination as well as a method of treating pain, e.g. chronic or acute pain, characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.
摘要翻译： 包含作为组分（a）化合物3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基） - 苯酚和（b）对乙酰氨基酚或其衍生物的组合物的组合，药物制剂和包含所述组合 以及治疗疼痛的方法，例如 慢性或急性疼痛，其特征在于组分（a）和（b）同时或依次施用于哺乳动物，其中组分（a）可以在组分（b）之前或之后施用，其中组分（a）或（b） 通过相同或不同的施用途径向哺乳动物施用。
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公开(公告)号：US20070249724A1
公开(公告)日：2007-10-25
申请号：US11774816
申请日：2007-07-09
IPC分类号： A61K31/135 , A61P29/00
CPC分类号： A61K31/635 , A61K31/135 , A61K31/137 , A61K31/341 , A61K31/365 , A61K31/415 , A61K2300/00
摘要： A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1RS,3RS,6RS)-6-dimethyl-aminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol compound, preferably in the form of a physiologically acceptable salt, such as the hydrochloride.
摘要翻译： 一种通过向哺乳动物施用有效的炎性疼痛缓解量的（1RS，3RS，6RS）-6-二甲基 - 氨基甲基-1-（3-甲氧基苯基） ） - 环己烷-1,3-二醇化合物，优选为生理上可接受的盐，如盐酸盐形式。
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公开(公告)号：US20070185212A1
公开(公告)日：2007-08-09
申请号：US11653222
申请日：2007-01-16
申请人： Petra Bloms-Funke , Elmar Friderichs , Ivars Graudums , Hagen-Heinrich Hennies , Achim Kless , Klaus Schiene , Oswald Zimmer
发明人： Petra Bloms-Funke , Elmar Friderichs , Ivars Graudums , Hagen-Heinrich Hennies , Achim Kless , Klaus Schiene , Oswald Zimmer
IPC分类号： A61K31/137 , C07C215/46
CPC分类号： C07C211/29 , C07C2601/18
摘要： The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or inhibition of depression, anxiety, pain and urinary incontinence, and to related methods of treating or inhibiting these disorders.
摘要翻译： 本发明涉及取代的氨基化合物，其制备方法，含有这些化合物的药物制剂以及这些物质在制备药物制剂中的用途，特别是用于治疗或抑制抑郁症，焦虑症，疼痛和尿失禁， 以及治疗或抑制这些疾病的相关方法。
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公开(公告)号：US08791268B2
公开(公告)日：2014-07-29
申请号：US13077452
申请日：2011-03-31
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
IPC分类号： A61K31/44 , C07D213/62
CPC分类号： C07D213/74 , C07D213/64 , C07D213/70
摘要： Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
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55.发明授权Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions 失效香草素受体配体，含有它们的药物组合物，制备它们的方法及其用途来治疗疼痛和其它病症公开(公告)号：US08785474B2
公开(公告)日：2014-07-22
申请号：US13210719
申请日：2011-08-16
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Bernd Sundermann , Jeewoo Lee
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Bernd Sundermann , Jeewoo Lee
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4709 , A61K31/4725
CPC分类号： C07D235/24 , C07D241/40 , C07D263/54 , C07D265/36 , C07D401/04
摘要： Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.
摘要翻译： 对应于式I的香草酸受体配体化合物：含有这些化合物的药物组合物，制备这些化合物的方法，以及使用这些化合物治疗或抑制疼痛和各种其它疾病或病症的方法。
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56.发明授权Vanilloid receptor ligands and use thereof for the production of pharmaceutical preparations 失效香草素受体配体及其用于制备药物制剂的用途公开(公告)号：US08710233B2
公开(公告)日：2014-04-29
申请号：US11551060
申请日：2006-10-19
申请人： Jeewoo Lee , Hyung Chul Ryu , Robert Frank , Gregor Bahrenberg , Jean De Vry , Thomas Christoph , Derek John Saunders , Klaus Schiene , Bernd Sundermann
发明人： Jeewoo Lee , Hyung Chul Ryu , Robert Frank , Gregor Bahrenberg , Jean De Vry , Thomas Christoph , Derek John Saunders , Klaus Schiene , Bernd Sundermann
IPC分类号： C07D213/40 , A61K31/44
CPC分类号： C07D409/04 , C07C311/08 , C07C2601/08 , C07C2601/14 , C07D211/14 , C07D211/18 , C07D213/40 , C07D213/64 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/83 , C07D223/04 , C07D225/02 , C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/04
摘要： The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.
摘要翻译： 本发明涉及新型香草酸受体配体，其制备方法，含有这些化合物的药物制剂以及这些化合物用于制备药物制剂的用途。
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公开(公告)号：US08592471B2
公开(公告)日：2013-11-26
申请号：US12775235
申请日：2010-05-06
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Nils Damann , Sven Frormann , Bernhard Lesch , Jeewoo Lee , Yong-Soo Kim , Myeong-Seop Kim , Derek Saunders , Hannelore Stockhausen
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Nils Damann , Sven Frormann , Bernhard Lesch , Jeewoo Lee , Yong-Soo Kim , Myeong-Seop Kim , Derek Saunders , Hannelore Stockhausen
IPC分类号： A61K31/41 , C07D231/12
CPC分类号： C07D231/12 , C07D249/08 , C07D401/04 , C07D405/06 , C07D417/06
摘要： The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
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公开(公告)号：US08404749B2
公开(公告)日：2013-03-26
申请号：US12834664
申请日：2010-07-12
IPC分类号： A61K31/135
CPC分类号： A61K31/635 , A61K31/135 , A61K31/137 , A61K31/341 , A61K31/365 , A61K31/415 , A61K2300/00
摘要： A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol compound or a physiologically acceptable salt thereof, such as the hydrochloride or citrate salt.
摘要翻译： 一种通过向哺乳动物施用有效的炎性疼痛缓解量的（1R，2R）-3-（2-二甲基氨基甲基 - 环己基） - 苯酚化合物或 其生理上可接受的盐，例如盐酸盐或柠檬酸盐。
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59.发明申请Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor 审中-公开取代的环状羧酰胺和尿素衍生物作为配子的香草素受体公开(公告)号：US20120046301A1
公开(公告)日：2012-02-23
申请号：US13213400
申请日：2011-08-19
IPC分类号： A61K31/496 , A61K31/415 , C07D401/14 , C07D401/04 , C07D231/12 , A61P29/00 , A61P25/06 , A61P25/24 , A61P25/28 , A61P25/00 , A61P25/08 , A61P11/00 , A61P13/00 , A61P13/02 , A61P1/00 , A61P27/02 , A61P17/00 , A61P31/22 , A61P1/12 , A61P3/00 , A61P19/02 , A61P19/10 , A61P25/30 , A61P25/32 , A61P9/00 , A61P17/02 , A61P15/00 , A61P25/16 , A61P11/06 , A61P11/08 , A61P3/04 , A61K31/4439
CPC分类号： C07D231/12 , C07D249/10 , C07D401/12 , C07D401/14 , C07D407/14 , C07D409/12
摘要： Substituted cyclic carboxamide and urea compounds, a process for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for the treatment and/or inhibition of pain and other conditions mediated by the vanilloid receptor 1.
摘要翻译： 取代的环状羧酰胺和脲化合物，其制备方法，含有这些化合物的药物组合物，以及这些化合物用于治疗和/或抑制由香草素受体1介导的疼痛和其它病症的用途。
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60.发明申请Axomadol or a Metabolite Thereof for Use in the Treatment of Irritable Bowel Syndrome 审中-公开阿莫莫多或其代谢物用于治疗肠易激综合征公开(公告)号：US20120022294A1
公开(公告)日：2012-01-26
申请号：US13172281
申请日：2011-06-29
IPC分类号： C07C215/42
CPC分类号： A61K31/135 , C07C217/74 , C07C2601/14
摘要： The invention relates to axomadol or a metabolite thereof for use in the treatment of irritable bowel syndrome.
摘要翻译： 本发明涉及用于治疗肠易激综合征的莫莫多或其代谢物。
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