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公开(公告)号：US20230204583A1
公开(公告)日：2023-06-29
申请号：US18057949
申请日：2022-11-22
Inventor： Kenneth R. Shroyer , Luisa F. Escobar-Hoyos , Emily I. Chen
IPC: G01N33/574 , C12Q1/6886
CPC classification number: G01N33/57411 , C12Q1/6886 , G01N2333/4742 , C12Q2600/158
Abstract: The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.
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公开(公告)号：US20230202872A1
公开(公告)日：2023-06-29
申请号：US18111264
申请日：2023-02-17
Inventor： Devinder Mahajan
IPC: C02F1/22
CPC classification number: C02F1/22 , C02F2209/03 , C02F2209/02 , C02F2201/009 , C02F2301/046 , C02F2201/008 , C02F2303/10 , C02F2103/32
Abstract: A method for treating wastewater, comprising: (i) injecting a hydrate-forming gas (e.g., propane) into the wastewater under conditions of elevated pressure and reduced temperature to form a solid hydrate composed of the hydrate-forming gas and water from the wastewater; and (ii) separating the solid hydrate from the wastewater to result in removal of water from the wastewater, thereby resulting in partially dewatered wastewater, and optionally, (iii) lowering the pressure and/or raising the temperature of the solid hydrate to decompose the solid hydrate into reformed hydrate-forming gas and reformed water, and further optionally, recycling the reformed hydrate-forming gas for use in step (i) and/or capturing the reformed water from step (iii) and further decontaminating until suitable for release into waterway or for use in a process. The invention is also directed to an apparatus for practicing the method described above.
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53.发明公开公开(公告)号：US20230174601A1
公开(公告)日：2023-06-08
申请号：US17992479
申请日：2022-11-22
Inventor： Matthew R. Pincus , Josef Michl , Ehsan Sarafraz-Yazdi
IPC: C07K14/47 , G01N33/50 , A61K45/06 , G01N33/574
CPC classification number: C07K14/4746 , G01N33/5011 , A61K45/06 , G01N33/57407 , G01N33/57492 , G01N33/57484 , A61K38/02
Abstract: An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form.
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54.发明公开公开(公告)号：US20230173292A1
公开(公告)日：2023-06-08
申请号：US17969131
申请日：2022-10-19
Applicant: The Research Foundation for the State University of New York , The University of North Carolina at Chapel Hill
Inventor： Clinton Rubin , Janet Rubin
CPC classification number: A61N2/02 , A61M5/00 , A61N1/05 , C12N13/00 , A61M31/002
Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.
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公开(公告)号：US20230149518A1
公开(公告)日：2023-05-18
申请号：US18092429
申请日：2023-01-02
Inventor： Karin Sauer , Amber L. Doiron
CPC classification number: A61K38/44 , A01N37/18 , A61K45/06 , C12Y102/04001 , C12R2001/38
Abstract: A method of treating a biofilm on a surface, comprising: providing a surface having a biofilm; and administering to the surface a treatment that reduces a concentration of pyruvate of the biofilm, comprising pyruvate produced by at least a portion the biofilm, under conditions effective reducing maintenance of the biofilm on the surface. A composition, comprising purified enzyme, within a particle, effective for reducing pyruvate concentration in an aqueous suspension of the composition.
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Patent Agency Ranking
56.发明公开公开(公告)号：US20230141417A1
公开(公告)日：2023-05-11
申请号：US17918230
申请日：2021-04-09
Inventor： Mobin Karimi , Alaji Bah
IPC: C12N15/113
CPC classification number: C12N15/1137 , C12N2310/14
Abstract: The present disclosure relates to compositions and methods for administering a subject in need thereof an effective amount of an inhibitor of interleukin-2-inducible T-cell kinase (ITK). In embodiments, the polypeptide of the present disclosure is characterized as an inhibitor and includes an amino acid sequence having at least 80% sequence identity to SEQ ID NO: 2, wherein the peptide inhibitor includes a phosphorylated tyrosine.
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公开(公告)号：US11643394B2
公开(公告)日：2023-05-09
申请号：US17244762
申请日：2021-04-29
Applicant: United States Government as represented by the Department of Veterans Affairs , Icahn School of Medicine at Mount Sinai , The Research Foundation for The State University of New York
Inventor： Sandeep Mallipattu , Bhaskar Das
IPC: C07D213/85 , C07D213/74 , A61K31/573 , C07C321/20
CPC classification number: C07D213/85 , A61K31/573 , C07C321/20 , C07D213/74
Abstract: The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20230132031A1
公开(公告)日：2023-04-27
申请号：US17914019
申请日：2021-03-23
Inventor： Lance Snead , Jason Trelewicz
IPC: G21C11/02 , C04B35/053 , G21F1/08 , G21C5/02 , G21C5/12
Abstract: A composite structure is disclosed comprising a neutron-absorbing metal hydride phase contained within a matrix having a density of greater than 95%. In various embodiments the metal hydride is a hydride of one or more of the following: Gadolinium, Hafnium, Europium, Samarium. The composite structure is utile as a shield for fusion or fission reactors.
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公开(公告)号：US11636918B2
公开(公告)日：2023-04-25
申请号：US16214327
申请日：2018-12-10
Applicant: University of Florida Research Foundation, Incorporated , The Research Foundation for the State University of New York
Inventor： Matthew D. Disney , Sai Velagapudi
IPC: G16B15/30 , G16B15/00 , G16B30/00 , C07D235/18 , C07D403/14 , C07H15/04 , G16B30/10 , C07D235/20 , C07H15/234 , G01N33/53
Abstract: Methods and computer systems are described herein for identifying small molecules that bind to selected RNA structural features (e.g., to RNA secondary structures). Also described are compounds and compositions that modulate RNA function and/or activity.
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公开(公告)号：US20230122801A1
公开(公告)日：2023-04-20
申请号：US17907826
申请日：2021-02-28
Inventor： Audrey Bernstein , Alexey Wolfson , Sean McCauley
IPC: C12N15/113
Abstract: The present disclosure provides compositions and methods for using self-deliverable siRNA (sdRNAi) directed against USP-10 for the treatment of various medical conditions, including skin scarring due to trauma wounds and surgery, corneal and retina scarring due to injury and surgery, internal organ scarring due to injury and surgery, heart tissue scarring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. In embodiments, compositions including self-deliverable siRNA (sdRNAi) directed against USP-10 are suitable for use in pharmaceutical formulations and treatments resulting in significant less scar formation, and include synthetic nucleic acids such as sense and antisense oligonucleotides.
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