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1.发明公开公开(公告)号：US20240342139A1
公开(公告)日：2024-10-17
申请号：US18615330
申请日：2024-03-25
发明人： Brian Kraemer
IPC分类号： A61K31/429 , A61P25/28 , C07C317/14 , C07D231/14 , C07D277/40 , C07D277/60 , C07D403/06 , C07D409/06 , C07D513/04 , C07D513/10 , C07D513/14
CPC分类号： A61K31/429 , A61P25/28 , C07C317/14 , C07D231/14 , C07D277/40 , C07D277/60 , C07D403/06 , C07D409/06 , C07D513/04 , C07D513/10 , C07D513/14
摘要： The present disclosure is concerned with substituted thiochromenothiazole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of neurodegenerative disorders associated with dysregulation of MSUT2 signaling such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), motor neuron disease, ataxia, progressive supranuclear palsy (PSP), multiple system atrophy, corticobasal degeneration (CBD), argyrophilic grain disease (AGD), Pick's disease (PiD), dementia, Huntington's disease (HD), primary age-related tauopathy (PART), and aging-related tau astrogliopathy (ARTAG). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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2.发明公开公开(公告)号：US20240335503A1
公开(公告)日：2024-10-10
申请号：US18579252
申请日：2022-07-15
发明人： Andrew Tan
摘要： The invention generally relates to methods of treating spasticity and/or neuropathic pain using known romidepsin and pharmaceutical compositions comprising same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240290473A1
公开(公告)日：2024-08-29
申请号：US18572113
申请日：2022-06-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Aydogan Ozcan , Jingxi Li , Yair Rivenson , Xiaoran Zhang , Philip O. Scumpia , Jason Garfinkel , Gennady Rubinstein
CPC分类号： G16H30/40 , A61B5/0068 , A61B5/0071 , G06T7/0012 , G06T15/08 , G06T2207/20084 , G06T2207/30088
摘要： A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies.
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公开(公告)号：US20240287175A1
公开(公告)日：2024-08-29
申请号：US18526952
申请日：2023-12-01
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Anton Wyss-Coray , John Vincent Pluvinage , Michael C. Bassik , Michael Haney , Benjamin Smith , Carolyn Bertozzi
IPC分类号： C07K16/28 , A61K38/47 , A61K39/00 , A61K39/395 , A61K47/68 , A61M25/00 , A61P25/28 , C12N9/24
CPC分类号： C07K16/2803 , A61K38/47 , A61K39/001113 , A61K39/3955 , A61K47/6815 , A61K47/6849 , A61P25/28 , C12N9/2402 , C12Y302/01018 , A61K2039/505 , A61M25/0097 , C07K2317/76 , C07K2317/77
摘要： Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
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公开(公告)号：US20240287153A1
公开(公告)日：2024-08-29
申请号：US18639779
申请日：2024-04-18
申请人： United States Government as represented by the Department of Veterans Affairs , University of Miami
发明人： Robert M. Jackson , Andrew V. Schally , Renzhi Cai
摘要： Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth.
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公开(公告)号：US20240239913A1
公开(公告)日：2024-07-18
申请号：US18411242
申请日：2024-01-12
申请人： The United States Government As Represented By The Department Of Veterans Affairs , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , OKLAHOMA MEDICAL RESEARCH FOUNDATION
CPC分类号： C07K16/2896 , A61P19/02 , C07K14/7455 , C12N9/12 , A61K38/00 , A61K2039/505 , C12Y207/12002
摘要： Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject.
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公开(公告)号：US20240207491A1
公开(公告)日：2024-06-27
申请号：US18380135
申请日：2023-10-13
申请人： VANDERBILT UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Timothy C. Boire , Hak-Joon Sung , Colleen Brophy
CPC分类号： A61L31/06 , A61F2/07 , A61F2/90 , A61L31/041 , A61L31/16 , C08G63/08 , A61L2400/16
摘要： The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photo crosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
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公开(公告)号：US20240182421A1
公开(公告)日：2024-06-06
申请号：US18547129
申请日：2022-03-17
申请人： Oregon Health & Science University , The United States Government as Represented by the Department of Veterans Affairs
发明人： Michael K. Riscoe , Aaron Nilsen , Haihong Jin , Sovitj Pou , Rolf W. Winter , Rozalia Ana Dodean , Katherine M. Liebman
IPC分类号： C07D215/233
CPC分类号： C07D215/233
摘要： Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.
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公开(公告)号：US11972050B2
公开(公告)日：2024-04-30
申请号：US17978271
申请日：2022-11-01
申请人： BROWN UNIVERSITY , THE GENERAL HOSPITAL CORPORATION , The United States Government as represented by the Department of Veterans Affairs
发明人： Leigh Hochberg , John D. Simeral , Tyler Singer-Clark , Ronnie Gross , Thomas Hosman , Anastasia Kapitonava , Rekha Crawford
IPC分类号： G06F3/01
CPC分类号： G06F3/015
摘要： Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command.
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公开(公告)号：US20240091429A1
公开(公告)日：2024-03-21
申请号：US18484617
申请日：2023-10-11
发明人： Andrew Kelley
IPC分类号： A61M1/00
CPC分类号： A61M1/90 , A61M2202/0496 , A61M2205/0216 , A61M2210/167
摘要： An external catheter system can comprise an external catheter comprising an engagement portion that is configured to receive and sealingly engage at least a portion of a penis of a user and an outlet. The system can further comprise a negative pressure source. A conduit can couple the negative pressure source to the external catheter. At least one of the external catheter and the conduit can comprise a portion that, upon application of a negative pressure by the negative pressure source, is configured to collapse to provide a pressure drop between the negative pressure source and the engagement portion of the external catheter.
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