公开(公告)号：US09949973B2

公开(公告)日：2018-04-24

申请号：US15204217

申请日：2016-07-07

Applicant: AbbVie Inc.

Inventor： Ping X Gao ,  Raimundo Ho ,  Jayanthy Jayanth ,  Samrat Mukherjee ,  Katherine E. Peterson ,  John C. Strong ,  Ping Tong ,  Geoff G. Zhang

IPC: A61K31/505 ,  A61J3/02 ,  A61K9/16 ,  B01F11/02

CPC classification number: A61K31/505 ,  A61J3/02 ,  A61K9/1688 ,  B01F11/02 ,  B01F2215/0032

Abstract: A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel containing the drug substance. The drug substance may be, for example, Elagolix.

公开(公告)号：US20170129902A1

公开(公告)日：2017-05-11

申请号：US15295561

申请日：2016-10-17

Applicant: AbbVie Inc.

Inventor： Aymen Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam Mohamed ,  Mathew Mulhern ,  Lars Fredrick Nordstroem ,  Ahmed Othman ,  Michael Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer

IPC: C07D487/14 ,  A61K47/12 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.