公开(公告)号：US20240252401A1

公开(公告)日：2024-08-01

申请号：US18290430

申请日：2022-05-19

申请人： WIZARD TABEZE LIMITED

发明人： Paul GREGORY

IPC分类号： A61J7/00 ,  A61J3/02

CPC分类号： A61J7/0007 ,  A61J3/02 ,  A61J2200/70

摘要： The present invention provides a pill grinder including a housing containing a grinding mechanism which is driven by a drive means.
The grinding mechanism comprises first and second relatively rotatable grinding plates, between which a pill is ground. The pill grinder further includes a powder reservoir for receiving ground pill powder; and at least one juddering device which is operative to apply a vibrating force in order to dislodge ground pill powder from surfaces or recesses within the housing.

公开(公告)号：US11896716B2

公开(公告)日：2024-02-13

申请号：US16759925

申请日：2018-10-30

申请人： ROQUETTE AMERICA, INC.

发明人： Carmen Popescu

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K31/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/17 ,  A61K31/21 ,  A61K31/355 ,  A61K45/00 ,  A61K45/06 ,  A61K47/36 ,  A61K47/44 ,  B01J13/04 ,  B05B5/00 ,  A61J3/02 ,  A61J3/06 ,  A61J3/07 ,  A61J3/10 ,  A23D9/05 ,  A23D7/005 ,  A23D9/007

CPC分类号： A61K9/1682 ,  A23D7/0053 ,  A23D9/007 ,  A23D9/05 ,  A61J3/02 ,  A61J3/06 ,  A61J3/07 ,  A61J3/074 ,  A61J3/10 ,  A61K9/16 ,  A61K9/167 ,  A61K9/20 ,  A61K9/2095 ,  A61K31/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/17 ,  A61K31/21 ,  A61K31/355 ,  A61K45/00 ,  A61K45/06 ,  A61K47/36 ,  A61K47/44 ,  B01J13/043 ,  B05B5/001

摘要： The invention relates to a new method for the formulation of oily substances, and to powders and solid dosage forms obtainable thereof. The process comprises a step of spray-drying of an oil-in-water emulsion comprising an octenyl succinate starch and a maltodextrin.

公开(公告)号：US20210137790A1

公开(公告)日：2021-05-13

申请号：US16759925

申请日：2018-10-30

申请人： ROQUETTE AMERICA, INC.

发明人： Carmen POPESCU

IPC分类号： A61J3/02 ,  A61J3/06 ,  A61J3/07 ,  B05B5/00

摘要： The invention relates to a new method for the formulation of oily substances, and to powders and solid dosage forms obtainable thereof. The process comprises a step of spray-drying of an oil-in-water emulsion comprising an octenyl succinate starch and a maltodextrin.

公开(公告)号：US20200368164A1

公开(公告)日：2020-11-26

申请号：US16637137

申请日：2018-08-07

申请人： THE UNIVERSITY OF AKRON

发明人： Matthew BECKER ,  Gregory Isaac PETERSON ,  Alexandra ABEL

IPC分类号： A61K9/14 ,  A61K9/06 ,  A61K47/34 ,  A61J3/02

摘要： In one or more embodiments, the present invention provide a novel drug loaded amino acid based poly(ester urea) polymers for use in drug delivery having shape memory properties and without the shortcomings of the polymers for drug delivery known in the art, as well as related methods for their synthesis and use.

公开(公告)号：US10792634B2

公开(公告)日：2020-10-06

申请号：US15747021

申请日：2016-08-01

申请人： Steerlife India Private Limited

发明人： Radhika Ghike ,  Vijay Kulkarni ,  Indu Bhushan ,  Himadri Sen ,  Babu Padmanabhan ,  Vinay Rao

IPC分类号： B01J2/20 ,  B29C48/40 ,  B29C48/92 ,  B01J2/28 ,  B01J2/30 ,  A61K9/16 ,  A61J3/02 ,  B29B9/06 ,  B29C48/59 ,  B29C48/57 ,  B29C48/04

摘要： A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.

公开(公告)号：US10561735B2

公开(公告)日：2020-02-18

申请号：US15817907

申请日：2017-11-20

申请人： Paladin Labs Inc. ,  Paladin Labs Europe Limited ,  Paladin Labs (Barbados) Inc.

发明人： Francois Ravenelle ,  Sandra Gori ,  David Lessard ,  Laibin Luo ,  Dorothee Le Garrec ,  Damon Smith

IPC分类号： A61K47/34 ,  A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K31/08 ,  A61K31/47 ,  A61K47/32 ,  A61K31/05 ,  A61J3/02 ,  A61K31/085 ,  B01F3/08

摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.

公开(公告)号：US10266287B2

公开(公告)日：2019-04-23

申请号：US14895311

申请日：2014-06-02

申请人： ESSENTRA FILTER PRODUCTS DEVELOPMENT CO. PTE. LTD

发明人： Gary Fulcher ,  James Reed

IPC分类号： B65B9/06 ,  A24B13/00 ,  B65B9/067 ,  B65B9/073 ,  A24F23/02 ,  A61J3/02 ,  B65B61/06 ,  B65B61/18 ,  A24D3/04 ,  A61M15/06

摘要： Processes for the manufacture of dispensers for an agent, for example, a therapeutic agent, for example a particulate therapeutic agent or a particulate foodstuff or snuff. The processes comprise the steps of continuously advancing, longitudinally, a flow of longitudinally extending dispensers and wrapping these dispensers by a common product wrapper. The dispensers comprise at least a base element (72), a cylindrical tubular element (73) with a cavity (74), a capping element (76) and a common outer wrapper (77).

公开(公告)号：US10188621B2

公开(公告)日：2019-01-29

申请号：US15668236

申请日：2017-08-03

申请人： Emisphere Technologies, Inc.

发明人： Halina Levchik ,  Shingai Majuru ,  Brahma Singh ,  Jamila Harris

IPC分类号： A61K31/197 ,  A61K9/20 ,  A61J3/02 ,  C07C235/60 ,  A61K31/198 ,  A61K45/06

摘要： The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.

公开(公告)号：US09999597B2

公开(公告)日：2018-06-19

申请号：US14763452

申请日：2014-01-24

申请人： NDM Technologies Limited

发明人： Dewan Fazlul Hoque Chowdhury

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61J3/00 ,  A61J3/02 ,  A61M37/00

CPC分类号： A61K9/14 ,  A61J3/00 ,  A61J3/02 ,  A61K9/0014 ,  A61K9/0021 ,  A61M2037/0053

摘要： Irregular, angular particles are produced by a manufacturing method that comprises forming a film on a substrate and then stretching the substrate along one or more axes to fracture the film into particle structures. The substrate may be moved continuously along a production line as the film is formed and may be stretched by accelerating that movement. The substrate may comprise a surface with elevated patterns to control the fracturing of the film. The particles are particularly suitable for the transdermal delivery of a biologically active substance into the body of a patient.

公开(公告)号：US09956144B2

公开(公告)日：2018-05-01

申请号：US13642397

申请日：2011-04-21

申请人： Marco Gil ,  Constanca Cacela ,  Ricardo Mendonca ,  Filipe Gaspar

发明人： Marco Gil ,  Constanca Cacela ,  Ricardo Mendonca ,  Filipe Gaspar

IPC分类号： A61J3/02 ,  A61K9/00 ,  A61K9/14 ,  A61K31/137 ,  A61K31/46 ,  A61K31/56 ,  A61K31/58

CPC分类号： A61J3/02 ,  A61K9/0075 ,  A61K9/14 ,  A61K31/137 ,  A61K31/46 ,  A61K31/56 ,  A61K31/58

摘要： A process for reducing the particle size of an active pharmaceutical ingredient (API) while maintaining its polymorphic form, comprises the step of processing the active pharmaceutical ingredient by cavitation at elevated pressure. The process preferably comprises the step of isolating the processed active ingredient in the form of powder, wherein the isolation step comprises filtration or spray drying. Particles produced by the process of the invention typically have a span value of less than 2.5.