公开(公告)号：US5280030A

公开(公告)日：1994-01-18

申请号：US862376

申请日：1992-04-02

申请人： Samir Jegham ,  Gerard DeFosse ,  Thomas Purcell ,  Johannes Schoemaker

发明人： Samir Jegham ,  Gerard DeFosse ,  Thomas Purcell ,  Johannes Schoemaker

IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61P1/08 ,  A61P25/00 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： A compound which is a piperidine derivative of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom, a linear or branched (C.sub.1-6)alkyl group or a cyclo(C.sub.3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formula N--R.sub.3 in which R.sub.3 is a hydrogen atom, or a linear or branched (C.sub.1-8)alkyl, cyclo(C.sub.3-6)alkyl, cyclo(C.sub.3-6)alkylmethyl, (C.sub.1-4)alkoxy-(C.sub.1-4)alkyl, phenyl, pyridin-4-yl, pyridin-3-yl, pyridin-4-ylmethyl or pyridin-3-ylmethyl group and Z represents a hydrogen or fluorine atom and acid addition salts thereof with pharmaceutically acceptable acids, can be used for the treatment and prevention of disorders in which 5-HT receptors are involved.

摘要翻译： 对应于通式（I）的化合物，其中R 1表示氢原子或直链或支链（C 1-6）烷基或环（C 3-8）烷基，X表示 氧原子或硫原子或其中R3是氢原子的通式为N-R3的基团，直链或支链（C1-8）烷基，环（C3-6）烷基，环（C3 -6）烷基甲基，（C 1-4）烷氧基（C 1-4）烷基，苯基，4-吡啶基或3-吡啶基，Z表示氢或氟原子，以及它们的加成盐 与药学上可接受的酸。 应用于治疗。