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    Piperidine derivatives, their preparation and their therapeutic application
    1.
    发明授权
    Piperidine derivatives, their preparation and their therapeutic application 失效
    哌啶衍生物，其制备及其治疗应用

    公开(公告)号：US5280030A

    公开(公告)日：1994-01-18

    申请号：US862376

    申请日：1992-04-02

    申请人： Samir Jegham ,  Gerard DeFosse ,  Thomas Purcell ,  Johannes Schoemaker

    发明人： Samir Jegham ,  Gerard DeFosse ,  Thomas Purcell ,  Johannes Schoemaker

    IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61P1/08 ,  A61P25/00 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

    CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： A compound which is a piperidine derivative of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom, a linear or branched (C.sub.1-6)alkyl group or a cyclo(C.sub.3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formula N--R.sub.3 in which R.sub.3 is a hydrogen atom, or a linear or branched (C.sub.1-8)alkyl, cyclo(C.sub.3-6)alkyl, cyclo(C.sub.3-6)alkylmethyl, (C.sub.1-4)alkoxy-(C.sub.1-4)alkyl, phenyl, pyridin-4-yl, pyridin-3-yl, pyridin-4-ylmethyl or pyridin-3-ylmethyl group and Z represents a hydrogen or fluorine atom and acid addition salts thereof with pharmaceutically acceptable acids, can be used for the treatment and prevention of disorders in which 5-HT receptors are involved.

    摘要翻译： 对应于通式（I）的化合物，其中R 1表示氢原子或直链或支链（C 1-6）烷基或环（C 3-8）烷基，X表示 氧原子或硫原子或其中R3是氢原子的通式为N-R3的基团，直链或支链（C1-8）烷基，环（C3-6）烷基，环（C3 -6）烷基甲基，（C 1-4）烷氧基（C 1-4）烷基，苯基，4-吡啶基或3-吡啶基，Z表示氢或氟原子，以及它们的加成盐 与药学上可接受的酸。 应用于治疗。

    Piperidine derivatives, their preparation and their application in therapeutics
    2.
    发明授权
    Piperidine derivatives, their preparation and their application in therapeutics 失效
    哌啶衍生物，其制备及其在治疗中的应用

    公开(公告)号：US5418241A

    公开(公告)日：1995-05-23

    申请号：US127058

    申请日：1993-09-27

    申请人： Samir Jegham ,  Gerard Defosse ,  Thomas Purcell

    发明人： Samir Jegham ,  Gerard Defosse ,  Thomas Purcell

    IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61P1/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D211/60 ,  C07D233/64 ,  C07D235/30 ,  C07D401/14

    CPC分类号： C07D401/14

    摘要： The invention provides a compound which is a piperidine derivative of formula (I) ##STR1## in which R.sub.1 is hydrogen or straight or branched (C.sub.1 -C.sub.6) alkyl, R.sub.2 is hydrogen or straight or branched (C.sub.1 -C.sub.8) alkyl, Z and Z.sub.1 which may be the same or different, each is hydrogen, chlorine, hydroxyl, amino, nitro, hydroxymethyl, (C.sub.1 -C.sub.2) alkyl, (C.sub.1 -C.sub.8) alkoxy straight or branched (C.sub.1 -C.sub.5) alkoxycarbonyl or aryl (C.sub.1 -C.sub.2) alkoxy, Z is in position 4, 6 or 7 and Z and Z.sub.1 cannot both be hydrogen, or its addition salt with a pharmaceutically acceptable acid and its therapeutic application.

    摘要翻译： 本发明提供了式（I）哌啶衍生物（Ⅰ）的化合物，其中R 1是氢或直链或支链（C 1 -C 6）烷基，R 2是氢或直链或支链（C 1 -C 8）烷基 ，可以相同或不同的Z和Z 1各自为氢，氯，羟基，氨基，硝基，羟甲基，（C1-C2）烷基，（C1-C8）烷氧基直链或支链（C1-C5）烷氧基羰基或芳基 （C1-C2）烷氧基，Z在4,6或7位，Z和Z1不能都是氢，或其加药盐与药学上可接受的酸及其治疗应用。

    Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof
    5.
    发明授权
    Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
    吡啶并嘧啶衍生物及其制备方法及其治疗用途

    公开(公告)号：US07893259B2

    公开(公告)日：2011-02-22

    申请号：US12415256

    申请日：2009-03-31

    申请人： Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

    发明人： Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

    IPC分类号： C07D471/04 ,  A61P35/00 ,  A61P35/02

    CPC分类号： C07D471/04

    摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

    摘要翻译： 本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用：及其酸加成盐，水合物和溶剂化物，以及对映异构体，非对映异构体和混合物的形式 其中。 本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。