公开(公告)号：US09156828B2

公开(公告)日：2015-10-13

申请号：US14419568

申请日：2013-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhongxing Zhang ,  Zhiwei Yin ,  John F. Kadow ,  Nicholas A. Meanwell

IPC: A61K31/553 ,  C07D471/00 ,  C07D413/12 ,  C07D403/12 ,  A61K31/5513 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D413/12 ,  A61K31/5513 ,  A61K31/553 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof: (F) wherein A is selected from the group consisting of: (F) and; (F) and wherein Z is: (F) are useful as HIV attachment inhibitors.

Abstract translation: 式I化合物，包括其药学上可接受的盐：（F）其中A选自：（F）和 （F），其中Z是：（F）可用作HIV附着抑制剂。

公开(公告)号：US20150274753A1

公开(公告)日：2015-10-01

申请号：US14433841

申请日：2013-10-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhongxing Zhang ,  Eric P. Gillis ,  Paul Michael Scola

IPC: C07D498/06 ,  C07D498/16

CPC classification number: C07D498/06 ,  C07D498/08 ,  C07D498/16 ,  C07D498/22

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US08629150B2

公开(公告)日：2014-01-14

申请号：US13625186

申请日：2012-09-24

Applicant: Bristol-Myers Squibb Company

Inventor： Tao Wang ,  Li-Qiang Sun ,  Paul Michael Scola ,  Zhongxing Zhang ,  Qian Zhao

IPC: C07D498/10 ,  C07D498/18 ,  A61K31/529 ,  A61P31/22

CPC classification number: C07D498/06

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20130253196A1

公开(公告)日：2013-09-26

申请号：US13861804

申请日：2013-04-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yasutsugu Ueda ,  Timothy P. Connolly ,  John F. Kadow ,  Nicholas A. Meanwell ,  Tao Wang ,  Chung-Pin H. Chen ,  Kap-Sun Yeung ,  Zhongxing Zhang ,  David Kenneth Leahy ,  Shawn K. Pack ,  Nachimuthu Soundararajan ,  Pierre Sirard ,  Kathia Levesque ,  Dominique Thoraval

IPC: C07F9/6561

CPC classification number: A61K31/675 ,  A61K31/497 ,  A61K45/06 ,  C07D471/04 ,  C07F9/062 ,  C07F9/5728 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/6561

Abstract: This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.