公开(公告)号：US20120129852A1

公开(公告)日：2012-05-24

申请号：US13388700

申请日：2010-08-11

Applicant: Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

Inventor： Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

IPC: A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/497 ,  A61P29/00 ,  A61K31/519 ,  A61P35/00 ,  A61P37/08 ,  A61P37/00 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04

Abstract: Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A1, A2, A3, R4 are as defined herein.

Abstract translation: 具有式（I）的化合物及其对映体和非对映异构体，药学上可接受的盐，（I）可用作激酶调节剂，包括Btk调节，其中A1，A2，A3，R4如本文所定义。

公开(公告)号：US07773224B2

公开(公告)日：2010-08-10

申请号：US11863424

申请日：2007-09-28

Applicant: Fan He ,  Shumin Cheng ,  Michael Frenzer ,  Bin Jiang ,  Vahid Goudarzi

Inventor： Fan He ,  Shumin Cheng ,  Michael Frenzer ,  Bin Jiang ,  Vahid Goudarzi

IPC: G01J3/51

CPC classification number: G01J1/124 ,  G01J2003/466

Abstract: A system (200) and method (800) for determining whether a sample object (203) has a color that is within a predetermined range is provided. The system (200) includes a light source (201) capable of projecting lights having different light wavelength spectrum upon the sample object (203). A controller (222) causes the light source (201) to project a first light wavelength spectrum upon the sample object (203), then another, then another, and so forth. While each light is projecting upon the object, a monochromatic image capture device (202) captures an image having luminous intensity information. The luminous intensity information, or a subset thereof selected by an image selection tool (232) is then compared to the statistical range, which is derived from a plurality of images taken of a reference object (403).

Abstract translation: 提供了一种用于确定样本对象（203）是否具有在预定范围内的颜色的系统（200）和方法（800）。 系统（200）包括能够将具有不同光波长光谱的光投射到样本物体（203）上的光源（201）。 控制器（222）使得光源（201）将样品（203）上的第一光波长谱投影到另一个，另一个则另一个等等。 当每个光投射在物体上时，单色图像捕获装置（202）捕获具有发光强度信息的图像。 然后将由图像选择工具（232）选择的发光强度信息或其子集与从参考对象（403）拍摄的多个图像导出的统计范围进行比较。

公开(公告)号：USD618212S1

公开(公告)日：2010-06-22

申请号：US29339200

申请日：2009-06-26

Applicant: Bin Jiang ,  Man-Zhong Wang ,  Shi-Pei Zhang

Designer： Bin Jiang ,  Man-Zhong Wang ,  Shi-Pei Zhang

公开(公告)号：US20090325961A1

公开(公告)日：2009-12-31

申请号：US12542762

申请日：2009-08-18

Applicant: Jingwu Duan ,  Bin Jiang

Inventor： Jingwu Duan ,  Bin Jiang

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/41 ,  A61K31/425 ,  C07D417/12 ,  C07D417/10 ,  C07D285/12 ,  C07D277/00 ,  C07D417/14

CPC classification number: C07D285/135 ,  C07D233/76 ,  C07D249/12 ,  C07D277/46 ,  C07D285/08

Abstract: Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is A1QA2-; Q is a bond, —C(═O)—, —OC(O)—, —C(═O)NR5—, —SOp—, —SOpNR5—, —C(O)O—, —NR5C(O)—, —OC(O)NR5—, —NR5C(O)O—, —S(O)pNR5C(O)—, —C(O)NR5S(O)p— —NR5S(O)p—, or —NR5C(═O)NR6—. Y is selected from hydrogen, C1-6alkyl, OR16, substituted C1-6alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A1 and A2 are independently selected from a bond, C1-3alkylene, or C1-3alkenylene, and R1-R11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.

Abstract translation: 提供了新型非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的肥胖症，糖尿病，炎症和免疫疾病： 或对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为AlQA2-; Q是键，-C（-O） - ， - OC（O） - ， - C（-O）NR5-，-SOp-，-SOpNR5-，-C（O） - （O）NR5 - ， - NR5C（O）O-，-S（O）pNR5C（O） - ， - C（O）NR5S（O） NR5C（-O）NR6-。 Y选自氢，C 1-6烷基，OR 16，取代的C 1-6烷基，环烷基，芳基，杂环和杂芳基。 A1和A2独立地选自键，C1-3亚烷基或C1-3亚烯基，R1-R11在本文中定义。 还提供了治疗包含所述化合物的肥胖症，糖尿病和炎性或免疫相关疾病的药物组合物，组合和方法。

公开(公告)号：US20070185056A1

公开(公告)日：2007-08-09

申请号：US11642508

申请日：2006-12-20

Applicant: Jingwu Duan ,  Bin Jiang

Inventor： Jingwu Duan ,  Bin Jiang

IPC: A61K31/695 ,  C07D333/22 ,  C07F7/02 ,  A61K31/428 ,  A61K31/426 ,  A61K31/433 ,  A61K31/381

CPC classification number: C07D285/135 ,  C07D233/76 ,  C07D249/12 ,  C07D277/46 ,  C07D285/08

Abstract: Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is -A1QA2-; Q is a bond, —C(═O)—, —OC(O)—, —C(═O)NR5—, —SOp—, —SOpNR5—, —C(O)O—, —NR5C(O)—, —OC(O)NR5—, —NR5C(O)O—, —S(O)pNR5C(O)—, —C(O)NR5S(O)p— —NR5S(O)p—, or —NR5C(═O)NR6—. Y is selected from hydrogen, C1-4alkyl, OR16, substituted C1-6alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A1 and A2 are independently selected from a bond, C1-3alkylene, or C1-3alkenylene, and R1-R11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.

Abstract translation: 提供了新型非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的肥胖症，糖尿病，炎症和免疫疾病： 或对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为-A 1 -QA 2 - ; Q是键，-C（-O） - ， - OC（O） - ， - C（-O）NR 5 - ， - SO 2 - C（O）O-，-NR 5 C（O） - ， - OC（O）NR 5 O - ， - NR 5 C（O）O-，-S（O）n NR 5 C （O） - ， - C（O）NR 5 S（O）p - （O） - 或-NR 5 C（-O）NR 6 - 。 Y选自氢，C 1-4烷基，OR 16，取代的C 1-6烷基，环烷基，芳基，杂环和杂芳基 。 A 1和A 2个独立地选自键，C 1-3 - 亚烷基或C 1-3 - 亚烷基 亚烯基，R 1 -R 11，如本文所定义。 还提供了治疗包含所述化合物的肥胖症，糖尿病和炎性或免疫相关疾病的药物组合物，组合和方法。

公开(公告)号：US07221575B1

公开(公告)日：2007-05-22

申请号：US11281227

申请日：2005-11-17

Applicant: Bin Jiang

Inventor： Bin Jiang

IPC: G11C15/00 ,  G11C7/00

CPC classification number: G11C15/00 ,  G11C29/816

Abstract: A pseudo ternary content addressable memory (PTCAM) device (100) can include a number of PTCAM blocks (102-0 to 102-63), each of which can include a number of standard PTCAM rows (106-0 to 106-63) and a standard memory row (104-0 to 104-63) for storing and providing mask information for the PTCAM rows. Redundancy for replacing a defective standard PTCAM row can be provided by a redundant section (108) that include fewer PTCAM rows than in a PTCAM block (102-0 to 102-63). Non-defective PTCAM rows within a standard PTCAM block containing a defective PTCAM row can continue to operate.

Abstract translation: 伪三元内容可寻址存储器（PTCAM）设备（100）可以包括多个PTCAM块（102-0至102-63），每个PTCAM块可以包括多个标准PTCAM行（106-0至106-63） 以及用于存储和提供PTCAM行的掩码信息的标准存储器行（104-0至104-63）。 用于替换有缺陷的标准PTCAM行的冗余可以由冗余部分（108）提供，其包括比PTCAM块（102-0至102-63）中更少的PTCAM行。 包含有缺陷的PTCAM行的标准PTCAM块内的无缺陷PTCAM行可以继续运行。

公开(公告)号：US07132432B2

公开(公告)日：2006-11-07

申请号：US10858978

申请日：2004-06-02

Applicant: Jingwu Duan ,  Chu-Biao Xue ,  James Sheppeck ,  Bin Jiang ,  Lihua Chen

Inventor： Jingwu Duan ,  Chu-Biao Xue ,  James Sheppeck ,  Bin Jiang ,  Lihua Chen

IPC: A61K31/147 ,  C07D453/02

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables L, Z0, R1, R4, R5, and R11 are defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), aggrecanase, or a combination thereof.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或药学上可接受的盐形式，其中变量L，Z 0，R 1，R 2， 4，R 5和R 11定义如本文所定义，其可用作基质金属蛋白酶（MMP），TNF-α转化酶的抑制剂 （TACE），软骨聚集蛋白聚糖酶或其组合。

公开(公告)号：US20050176716A1

公开(公告)日：2005-08-11

申请号：US11034652

申请日：2005-01-13

Applicant: Jingwu Duan ,  Bin Jiang ,  James Sheppeck ,  John Gilmore

Inventor： Jingwu Duan ,  Bin Jiang ,  James Sheppeck ,  John Gilmore

IPC: A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/498 ,  A61K31/50 ,  C07D241/36 ,  C07D403/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D43/02

CPC classification number: C07D403/12 ,  C07D241/36 ,  C07D417/12 ,  C07D417/14

Abstract: A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least two of X1-X4 and/or X5-X8 is N or NR18, and R, Ra, Rb, Rc, Rd, R1, R2 and R18 are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Abstract translation: 提供了一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有 式（I）其立体异构体，或其溶剂化物，或其前药，或其药学上可接受的盐，其中Z为CONR 1，R 2或CH 2 > 2个NR 2 R 2，并且其中X 1 -X 4中的至少两个和 /或X 5 -X 8是N或NR 18，R，R a，R SUP R 1，R 2，R 2，R 2，R 2，R 2， > 18 。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

公开(公告)号：US06353112B1

公开(公告)日：2002-03-05

申请号：US09314339

申请日：1999-05-19

Applicant: David C. Baker ,  Bin Jiang

Inventor： David C. Baker ,  Bin Jiang

IPC: C07D27506

CPC classification number: C07D275/06

Abstract: Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.

Abstract translation: 公开了具有有效的抗HIV活性的生物活性苏丹。 描述了使用固体支持物及其变体的组合合成方法。 描述了用包含本发明的苏丹，特别是HIV的组合物治疗哺乳动物进行病毒感染的生物组合物和方法。

公开(公告)号：USD1011479S1

公开(公告)日：2024-01-16

申请号：US29881000

申请日：2023-07-31

Applicant: Bin Jiang

Designer： Bin Jiang

Abstract: FIG. 1 is a front, right and top perspective view of a watering can, showing my new design;
FIG. 2 is a rear, left and bottom perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines shown in the drawings illustrate portions of the watering can that form no part of the claimed design.