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    Synthesis and pharmacological activity of a series of novel xanthone derivatives
    51.
    发明授权
    Synthesis and pharmacological activity of a series of novel xanthone derivatives 失效
    一系列新型呫吨酮衍生物的合成和药理活性

    公开(公告)号：US5495005A

    公开(公告)日：1996-02-27

    申请号：US112704

    申请日：1993-08-26

    申请人： Chun-Nan Lin ,  Che-Ming Teng ,  Ing-Jun Chen ,  Shwu-Jen Liou ,  Shorong-Shii Liou ,  Feng-Nien Ko

    发明人： Chun-Nan Lin ,  Che-Ming Teng ,  Ing-Jun Chen ,  Shwu-Jen Liou ,  Shorong-Shii Liou ,  Feng-Nien Ko

    IPC分类号： C07C45/46 ,  C07C49/84 ,  C07D311/86 ,  C07H17/04 ,  C07H15/244

    CPC分类号： C07H17/04 ,  C07C45/46 ,  C07C49/84 ,  C07D311/86

    摘要： A compound, and salts thereof, represented by either formula I or formula II below:(1) Formula I: ##STR1## wherein substituents R.sub.1 -R.sub.7 can be, independently, hydrogen, hydroxy group, C.sub.1-6 alkyl(oxy) group, acetyl ester, or C.sub.1-12 alkyl propanolamine; at least three but no more than four of the substituents are alkyl(oxy) group, hydroxyl group or acetyl ester; no more than one of the substituents can be C.sub.1-12 alkyl propanolamines; R.sub.1, R.sub.3, R.sub.7 cnnnot all be hydroxy groups at the same time; and R.sub.6 is either an hydroxy group or an oxygen-containing glucose.(2) Formula II: ##STR2## wherein substituents R.sub.1 -R.sub.9 can be, indenpendently, hydrogen, hydroxy group and C.sub.1-6 alkyl(oxy) group; and no more then four of the substituents can be methoxy group, hydroxy group, or acetyl ester. These compounds were tested to be capable of inhibiting platelet aggregation, atrioventricular conduction, and calcium influx in myocardiac cells.

    摘要翻译： 由下式I或式II表示的化合物及其盐：（1）式I：有侧链，氢，羟基，C 1-6烷基（氧基），乙酰基酯或C 1-12烷基丙醇胺; 至少三个但不超过四个取代基是烷基（氧基），羟基或乙酰基酯; 不超过一个取代基可以是C 1-12烷基丙醇胺; R1，R3，R7不同时为羟基; R6为羟基或含氧葡萄糖。 （2）式II：其中取代基R 1 -R 9可以是氢，羟基和C 1-6烷基（氧基）基团; 并且不超过4个取代基可以是甲氧基，羟基或乙酰基酯。 测试这些化合物能够抑制心肌细胞中的血小板聚集，房室传导和钙流入。