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公开(公告)号：US20240148038A1
公开(公告)日：2024-05-09
申请号：US18277751
申请日：2022-02-17
摘要： tract: The present invention relates to the use of a compound of Formula (I) or a stereoisomer or salt thereof, wherein R1 is a saccharide consisting of 1 or 2 monosaccharide units as taste masker and to taste-masking compositions containing said compounds.
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公开(公告)号：US20180105548A1
公开(公告)日：2018-04-19
申请号：US15511014
申请日：2016-06-15
发明人： Yongnam LEE , Ji-seok YOO , Dae-hee SHIN , Byung-hwan RYOO , Sei-ryang OH , Kyung-seop AHN , Hyeongkyu LEE , Su Ui LEE , Hyuk-hwan SONG , Hyung Won RYU
CPC分类号： C07H17/04 , A23L33/105 , A23L33/30 , A23V2002/00 , A61K9/0019 , A61K9/0095 , A61K9/2018 , A61K9/2059 , A61K36/80 , A61K47/02 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , C07H17/08
摘要： (1aS,1bS,2S,4S,5aR,6S,6aS)-1a-(hydroxymethyl)-4-methoxy-2-(((2S,3R,5S5,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octahydrooxireno[2′,3′:4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxybenzoate}, the isomer thereof, the pharmaceutically acceptable salt or solvates thereof, a composition comprising the same as an active ingredient for treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and the use thereof.
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公开(公告)号：US09901648B2
公开(公告)日：2018-02-27
申请号：US14374388
申请日：2013-01-25
发明人： Heather D. Maynard , Rock J. Mancini , Juneyoung Lee , En-Wei Lin
IPC分类号： A61K47/58 , C07H3/04 , C08F110/00 , C08F10/00 , C08F210/00 , C07H17/04 , A61K31/713 , A61K38/47
CPC分类号： A61K47/58 , A61K31/713 , A61K38/47 , C07H3/04 , C07H17/04 , C08F10/00 , C08F110/00 , C08F210/00 , C12Y302/01017
摘要： Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.
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公开(公告)号：US09872872B2
公开(公告)日：2018-01-23
申请号：US14879280
申请日：2015-10-09
IPC分类号： C07H17/04 , A61K31/7048 , C12P19/18 , C12P19/60 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
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公开(公告)号：US20170360819A9
公开(公告)日：2017-12-21
申请号：US14879280
申请日：2015-10-09
IPC分类号： A61K31/7048 , C12P19/18 , A61K9/16 , C12P19/60 , C07H17/04
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
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公开(公告)号：US20170151271A1
公开(公告)日：2017-06-01
申请号：US15412161
申请日：2017-01-23
IPC分类号： A61K31/7048 , A61K31/045 , A61K31/353
CPC分类号： A61K31/7048 , A61K31/045 , A61K31/353 , A61K31/704 , A61K45/06 , C07H15/256 , C07H17/04 , A61K2300/00
摘要： The invention discloses novel endocrine treatment phytochemicals which affect androgenic status. The method for treatment of 5-alpha-reductase responsive diseases using four novel 5-alpha-reductase inhibitor compounds; leucoanthocyanidin, glabrene, glabridin, and alpha-terpineol is disclosed. Glabridin does not interfere with normal testosterone to androgen receptor binding.
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公开(公告)号：US20160220704A1
公开(公告)日：2016-08-04
申请号：US15012795
申请日：2016-02-01
发明人： H. Charles Manning , Yiu-Yin Cheung , Jason R. Buck , Jun Li
IPC分类号： A61K49/00 , C07D487/04 , G01N33/574 , G01N33/60 , G01N33/50 , C07D519/00 , C07H17/04
CPC分类号： A61K49/0052 , A61K49/0041 , A61K51/0459 , C07D487/04 , C07D519/00 , C07H17/04
摘要： Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.
摘要翻译： 本发明的实施方案包括易位蛋白（TSPO）配体的新型合成，以及成像分子事件的方法。 还公开了用于治疗包括癌症在内的疾病的化合物。
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8.发明授权Method for generating human milk oligosaccharides (HMOs) or precursors thereof 有权产生人乳寡糖（HMO）或其前体的方法公开(公告)号：US09234225B2
公开(公告)日：2016-01-12
申请号：US14117348
申请日：2012-05-14
申请人： Gyula Dekany , Elise Champion , Andreas Schroven , Markus Hederos
发明人： Gyula Dekany , Elise Champion , Andreas Schroven , Markus Hederos
IPC分类号： C12P19/04 , C12P19/12 , C12P19/14 , C07H17/02 , C07H17/04 , C07H9/06 , C08B37/00 , A23L1/29 , C12P19/18 , C07H17/075 , C07H19/01
CPC分类号： C12P19/14 , A23L33/40 , C07H9/06 , C07H17/02 , C07H17/04 , C07H17/075 , C07H19/01 , C08B37/006 , C12P19/04 , C12P19/12 , C12P19/18 , C12Y302/0114
摘要： A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).
摘要翻译： 一种生产人乳寡糖（HMO）或其前体的方法，可通过该方法获得的化合物，以及涉及这些化合物的用途和组合物。 所述方法包括以下步骤：a）提供至少一种选自式5至10中任一项的化合物的供体，b）从乳糖，LNT，LNnT及其衍生物组中提供至少一种受体，c）提供 至少一种酶，其包含转糖苷酶活性和/或糖基转移酶活性，d）制备所述至少一种供体，至少一种受体和至少一种在步骤a），b）和c）中提供的酶的混合物; 和e）培养根据步骤d）制备的混合物。
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公开(公告)号：US20150376200A1
公开(公告)日：2015-12-31
申请号：US14768284
申请日：2014-02-07
发明人： Young Gyu KANG , Jong Won SHIM , Jin Sup SHIM , Joon Ho PARK , Myeong Hun YEOM , Jun Cheol CHO
IPC分类号： C07D493/04 , A01N43/16
CPC分类号： C07D493/04 , A01N43/16 , A01N63/02 , A61K36/48 , A61K2236/00 , C07H17/04
摘要： Disclosed are a method for preparing coumestrol and a method for preparing coumestrin preparation, wherein chitosan is treated for a predetermined amount of time during a bean growth period. Additionally, disclosed is the method for preparing coumestrol by performing an enzyme treatment or an acid treatment and the like on the coumestrin prepared by the preparation method.
摘要翻译： 公开了一种制备香豆素的方法和一种制备香豆素制剂的方法，其中在豆生长期间将壳聚糖处理预定量的时间。 此外，公开了通过对通过制备方法制备的香豆素进行酶处理或酸处理等来制备香豆素的方法。
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公开(公告)号：US20150218196A1
公开(公告)日：2015-08-06
申请号：US14409604
申请日：2013-06-20
发明人： Adriaan Jacobus Minnaard , Manuel Jäger , Aditya Lakshmi Narasimha Raju Gottumukkala , Johannes Gerardus de Vries , Andreas Alexander Bastian , Andreas Herrmann
CPC分类号： C07H15/222 , C07H1/00 , C07H3/02 , C07H3/04 , C07H3/06 , C07H5/06 , C07H15/04 , C07H15/18 , C07H15/22 , C07H15/224 , C07H15/226 , C07H15/228 , C07H15/23 , C07H15/232 , C07H15/234 , C07H17/04 , C07H23/00
摘要： The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.
摘要翻译： 本发明涉及碳水化合物化学领域。 提供了一种用于区域选择性氧化包含两个或更多个次级羟基官能团的碳水化合物底物的单次级羟基官能团的方法，包括在过渡金属催化剂配合物与氧化剂存在下使碳水化合物底物在溶剂中接触，得到 单氧化碳水化合物。
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