公开(公告)号：US06774144B1

公开(公告)日：2004-08-10

申请号：US09703804

申请日：2000-11-01

申请人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

发明人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

IPC分类号： A61K3134

CPC分类号： A61K31/138 ,  A61K31/19 ,  A61K31/34 ,  A61K31/366 ,  A61K31/56 ,  A61K31/573

摘要： In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.

摘要翻译： 一方面，本发明涉及在需要这种治疗的禽类受试者中治疗传染性法氏囊病（IBD）的方法。 该方法包括向受试者施用足以治疗IBD的量的式（I）至（IV）化合物或其药学上可接受的盐。 另一方面，本发明涉及在禽类受试者中产生针对传染性法氏囊病毒病（IBD）的主动免疫的方法。 该方法包括向受试者施用免疫原性量的IBDV疫苗和选自本文所述的式（I）至（IV）的化合物的化合物。 由式（I）至（IV）表示的化合物以足以在禽类受试者中诱导免疫应答的量施用。

公开(公告)号：US06423737B1

公开(公告)日：2002-07-23

申请号：US09759664

申请日：2001-01-12

申请人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

发明人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

IPC分类号： A61K3115

摘要： A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.

公开(公告)号：US5723495A

公开(公告)日：1998-03-03

申请号：US558716

申请日：1995-11-16

申请人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

发明人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

IPC分类号： C07D307/52 ,  A61K31/00 ,  A61K31/15 ,  A61K31/155 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61P11/00 ,  A61P31/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C259/18 ,  C07D235/24 ,  C07D307/54 ,  C07D307/68 ,  C07D333/24 ,  A61K31/165

CPC分类号： A61K31/15 ,  A61K31/155 ,  A61K31/341 ,  C07C257/18 ,  C07C259/18 ,  C07D307/54 ,  C07D307/68 ,  C07D333/24

摘要： A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime of formula I: ##STR1## wherein R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl or alkylaminoalkyl; R.sub.3 is H, loweralkyl, oxyalkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, aryl, aminoalkyl, alkylaminoalkyl or halogen; n is from 2 to 6; X is O, N, or S; and Y is H or loweralkyl, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P, carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.

摘要翻译： 公开了在需要这种治疗的受试者中治疗卡氏肺囊虫肺炎的方法。 该方法包括向受试者口服给予式I的双 - 苯甲脒：其中R 1和R 2各自独立地选自H，低级烷基，烷氧基烷基，烷氧基烷基，环烷基，芳基，羟基烷基，氨基烷基 或烷基氨基烷基; R3是H，低级烷基，氧烷基，烷氧基烷基，羟基烷基，环烷基，芳基，氨基烷基，烷基氨基烷基或卤素; n为2至6; X是O，N或S; 并且Y是H或其烷基或其药学上可接受的盐，其在受试者中减少以产生具有抗P，卡尼氏菌活性的苯甲脒。 本发明的方法可以选择性地向受试者静脉内施用本文所公开的活性化合物。 还公开了可用于本发明实践的药物制剂和活性化合物。