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    Methods and formulations for the treatment of infectious bursal disease in avian subjects
    1.
    发明授权
    Methods and formulations for the treatment of infectious bursal disease in avian subjects 失效
    用于治疗禽类受试者传染性法氏囊病的方法和配方

    公开(公告)号：US06774144B1

    公开(公告)日：2004-08-10

    申请号：US09703804

    申请日：2000-11-01

    申请人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

    发明人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

    IPC分类号： A61K3134

    CPC分类号： A61K31/138 ,  A61K31/19 ,  A61K31/34 ,  A61K31/366 ,  A61K31/56 ,  A61K31/573

    摘要： In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.

    摘要翻译： 一方面，本发明涉及在需要这种治疗的禽类受试者中治疗传染性法氏囊病（IBD）的方法。 该方法包括向受试者施用足以治疗IBD的量的式（I）至（IV）化合物或其药学上可接受的盐。 另一方面，本发明涉及在禽类受试者中产生针对传染性法氏囊病毒病（IBD）的主动免疫的方法。 该方法包括向受试者施用免疫原性量的IBDV疫苗和选自本文所述的式（I）至（IV）的化合物的化合物。 由式（I）至（IV）表示的化合物以足以在禽类受试者中诱导免疫应答的量施用。

    Methods of treating microbial infections
    6.
    发明授权
    Methods of treating microbial infections 失效
    治疗微生物感染的方法

    公开(公告)号：US5668167A

    公开(公告)日：1997-09-16

    申请号：US477876

    申请日：1995-06-07

    申请人： Richard R. Tidwell ,  James E. Hall ,  David W. Boykin ,  Christine C. Dykstra ,  John Perfect ,  Byron L. Blagburn

    发明人： Richard R. Tidwell ,  James E. Hall ,  David W. Boykin ,  Christine C. Dykstra ,  John Perfect ,  Byron L. Blagburn

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/505 ,  A61P11/00 ,  A61P31/00 ,  C07D209/86 ,  C07D209/88 ,  C07D403/14

    CPC分类号： C07D403/14 ,  A61K31/403 ,  A61K31/4178 ,  C07D209/88

    摘要： The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or ##STR2## wherein: each R.sub.2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.2 groups together represent C.sub.2 -C.sub.10 alkylene, or two R.sub.2 groups together represent ##STR3## wherein m is from 1-3 and R.sub.4 is H, ##STR4## or --CONHR.sub.5 NR.sub.6 R.sub.7, whereinR.sub.5 is loweralkyl, R.sub.6 and R.sub.7 are each independently selected from the group consisting of H and lower alkyl; each R.sub.8 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl, or two R.sub.8 groups together represent C.sub.2 -C.sub.10 alkylene; R.sub.9 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.3 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.1 is H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, or halogen; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗隐球菌新隐球蛋白，小隐孢子虫和白色念珠菌的方法。 所述方法包括向受试者施用式I化合物：其中：X位于对位或间位，且为低级烷基，低级烷氧基，烷氧基烷基，羟烷基，氨基烷基，烷基氨基烷基，环烷基，芳基，烷基芳基， 卤素或其中：每个R 2独立地选自H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷芳基，或两个R 2基团一起表示C 2 -C 10亚烷基或两个R 2 基团一起表示，其中m为1-3，R4为H，IMA或-CONHR5NR6R7，其中R5为低级烷基，R6和R7各自独立地选自H和低级烷基; 每个R 8独立地选自H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基，或两个R 8基团一起表示C 2 -C 10亚烷基; R9是H，羟基，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基; R3是H，羟基，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基; R1是H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基，烷基芳基或卤素; 或其药学上可接受的盐。